Chordin (CHRD) ELISA Kits

CHRD encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. Additionally we are shipping Chordin Antibodies (85) and Chordin Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
CHRD 8646 Q9H2X0
CHRD 12667 Q9Z0E2
CHRD 117275  
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Top Chordin ELISA Kits at

Showing 7 out of 18 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Mouse 45 pg/mL 49.2 pg/mL - 12000 pg/mL 96 Tests 3 to 4 Days
Rat 0.056 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests 13 to 16 Days
Human 0.078 ng/mL n/a Typical standard curve 96 Tests 15 to 18 Days
Mouse 4.9 pg/mL n/a   96 Tests 11 to 16 Days
Human 37.2 pg/mL 78.125 pg/mL - 5000 pg/mL   96 Tests 15 to 17 Days
Human < 0.119 ng/mL 0.312 ng/mL - 20 ng/mL   96 Tests 11 to 18 Days
Rat < 0.056 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests 11 to 18 Days

Top referenced Chordin ELISA Kits

  1. Human CHRD ELISA Kit for Sandwich ELISA - ABIN417851 : Tekari, May, Frauchiger, Chan, Benneker, Gantenbein: The BMP2 variant L51P restores the osteogenic differentiation of human mesenchymal stromal cells in the presence of intervertebral disc cells. in European cells & materials 2017 (PubMed)

More ELISA Kits for Chordin Interaction Partners

Rabbit Chordin (CHRD) interaction partners

  1. Data show that BMP-2, BMP-4, and BMP-7, noggin, and chordin were colocalized in rimming osteoblasts, osteoclasts, and chondrocytes.

Human Chordin (CHRD) interaction partners

  1. Data suggest CHRD (chordin) cleavage by tolloid-like metalloproteinases is insufficient to regulate BMP(bone morphogenetic protein)/BMPR signaling; CHRD fragments and TSG (twisted gastrulation protein) contribute to inhibition of BMP/BMPR signaling.

  2. C-terminal chordin domains play an important role in Bone morphogenetic protein regulation.

  3. chordin silencing increased osteogenic differentiation without supplemented BMP-2.

  4. results suggest that CHRD could participate in regulating BMP activity in normal ovarian surface epithelium physiology, and that its mis-expression in ovarian surface epithelium may facilitate cancer incidence and/or progression

  5. Bone morphogenetic protein (BMP) chordin is produced endogenously during osteogenic differentiation of human mesenchymal stem cells (MSCs); blockade of bone morphogenetic inhibitor chordin increases the rate of osteogenic differentiation of MSCs in vitro.

  6. Noggin and chordin were also expressed most intensely in areas of cartilage formation and there was no difference in their expression between the non-hypertrophic and hypertrophic chondrocytes.

  7. there was no difference in the expression of the noggin and chordin between healing and nonhealing fractures

  8. Alternatively spliced variants have different patterns of expression to influence BMP activity in varying physiolgical situations.

Mouse (Murine) Chordin (CHRD) interaction partners

  1. Chordin upregulated in primary satellite cell cultures and in regenerating muscles

  2. The data indicate a role for CV2 and Chd in the establishment of the vertebral morphogenetic field through the long-range relocalization of Chd/BMP complexes.

  3. Data show that Brorin-like was predominantly expressed in the adult brain and embryonic neural tissues.

  4. role in promoting lineage commitment in embryonic stem cells

  5. the BMP antagonists chordin and noggin promote the inductive and trophic activities of rostral organizing centers in early development of the mammalian head

  6. products of Bmp1 and Tll1 are responsible for in vivo cleavage of Chordin in mammals

  7. chordin antagonism of bone morphogenetic protein signaling and cellular uptake of chordin require cell-surface heparan sulfate proteoglycans

  8. results suggest that twisted gastrulation and chordin are involved in osteoblast differentiation and mineralization by regulating BMP signaling

  9. These results demonstrate that the chordin contributes to synaptic plasticity and learning likely through a presynaptic mechanism.

  10. chordin has a role in venous and arterial patterning and the Bone Morphogenetic Protein pathway is necessary for the process

  11. chordin is a modifier for the craniofacial anomalies of Tbx1 mutations.

Zebrafish Chordin (CHRD) interaction partners

  1. The authors found that BMP2b and Chordin diffuse and rapidly form extracellular protein gradients, Chordin does not modulate the diffusivity or distribution of BMP2b, and Chordin is not required to establish peak levels of BMP signaling.

  2. activation of the FGF signaling pathway induces the formation of a dorsal axis with a complete head structure through the expression of chd and subsequent maintenance of dkk1b expression levels.

  3. Binding of CV2 to Chordin promotes BMP-2 signaling.

  4. Targeted knockdown of Sox17 and Chd in dorsal forerunner cells led to aberrant Left-Right (L-R) asymmetry establishment, as visualized by the expression of southpaw and lefty, and heart and pancreas placement in the embryo.

  5. Chl, like Chd, dorsalizes embryos upon overexpression and is cleaved by BMP1; loss-of-function experiments show Chl serves as a BMP antagonist with functions that overlap and are redundant with those of Chd in forming the dorsoventral axis.

  6. Data show that The inhibition of Brorin-like functions in zebrafish resulted in the impairment of neural development.

  7. by regulating the expression of her5, the Bmp2b/Chordin gradient directs the anteroposterior patterning of endoderm in zebrafish embryos

  8. chd, a bone morphogenetic protein antagonist expressed in gastrulation, is dispensable for neural crest induction.

  9. Twisted gastrulation enhances BMP signaling through chordin dependent and independent mechanisms

  10. specification of anterior neural tissue requires later activities of Chordin and mesodermal factors.

  11. Required both during and after gastrulation for proper patterning of the tail.

  12. While Chordin is the main player of the D/V axis, the structures remaining in the chd mutant in both mesodermal and ectodermal layers) result from the anti-Bmp activity carried by Nog1 and Fstl2 at blastula and gastrula stages.

  13. Chordin expression is required for the 'ciuffo' phenotype and for expression of neural markers when both beta-catenins are inhibited.

Xenopus laevis Chordin (CHRD) interaction partners

  1. Chordin protein formed a smooth gradient that encircled the embryo, reaching the ventral-most Brachet cleft.

  2. This study demonstrates a crucial role of Sizzled in coupling dorsal-ventral axis size information with Chordin stability.

  3. Chordin, Noggin, beta-Catenin, and Cerberus have roles in neural induction in Xenopus

  4. Bone morphogenetic protein 4 knockdown was sufficient to rescue the ventralizing effects caused by loss of Chordin activity.

  5. complex containing Smicl and the newly induced Xlim1 induces expression of Chordin

  6. Several lines of evidence support the hypothesis that chordin influences pronephros development by directing the formation of anterior somites.

  7. Embryo elongation can occur through the synergistic effect(s) of the organizer molecule chordin, and each of the 'verall posteriorizing molecules'eFGF, VegT and Xbra.

  8. Xld cleaves Chordin, an inhibitory binding protein for BMP2/4, releasing fragments with reduced affinity for these important ventralizing signals.

  9. CV2/Chordin interaction may help coordinate bone morphogenetic protein (BMP) diffusion to the ventral side of the embryo, ensuring that BMPs liberated from Chordin inhibition by tolloid proteolysis cause peak signaling levels.

  10. Study shows that Xenopus ONT1, an Olfactomedin-class secreted protein, stabilizes axial formation by restricting Chordin activity on the dorsal side. [ONT1]

Chordin (CHRD) Antigen Profile

Antigen Summary

This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequence has not been determined.

Gene names and symbols associated with Chordin (CHRD) ELISA Kits

  • chordin (CHRD) antibody
  • chordin, gene 1 (chrd.1) antibody
  • chordin (LOC778563) antibody
  • chordin (Chrd) antibody
  • chordin (chrd) antibody
  • chordin, gene 1 S homeolog (chrd.1.S) antibody
  • Chd antibody
  • chordino antibody
  • wu:fe47d04 antibody
  • X-chordin antibody

Protein level used designations for Chordin (CHRD) ELISA Kits

chordin , chordin protein , din , dino (din) , fe47d04 , protein chordino , organizer-specific secreted-dorsalizing factor

100067164 Equus caballus
100008933 Oryctolagus cuniculus
395828 Gallus gallus
549011 Xenopus (Silurana) tropicalis
778563 Ciona intestinalis
8646 Homo sapiens
12667 Mus musculus
117275 Rattus norvegicus
30161 Danio rerio
607289 Canis lupus familiaris
509942 Bos taurus
398045 Xenopus laevis
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