anti-ClpP Caseinolytic Peptidase, ATP-Dependent, Proteolytic Subunit Homolog (E. Coli) (CLPP) Antibodies

The protein encoded by CLPP belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. Additionally we are shipping CLPP Kits (8) and CLPP Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CLPP 53895 O88696
CLPP 8192 Q16740
CLPP 301117  
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Top anti-CLPP Antibodies at antibodies-online.com

Showing 10 out of 73 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN184946 (1 µg/mL) staining of Human Heart lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. ABIN184946 (2.5 µg/mL) staining of paraffin embedded Human Liver. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 100 μg Log in to see 6 to 7 Days
$429.84
Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated FACS, IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$522.50
Details
Dog Mouse Un-conjugated FACS, IF, IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$522.50
Details
Dog Mouse Un-conjugated FACS, IF, WB 100 μL Log in to see 11 to 14 Days
$522.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB ICC/IF Image CLPP antibody [C2C3], C-term detects CLPP protein at mitochondria by immunofluorescent analysis. Sample: A431 cells were fixed in 2% paraformaldehyde/culture medium at RT for 30 min. Green: CLPP protein stained by CLPP antibody [C2C3], C-term , diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10 μm. WB Image CLPP antibody detects CLPP protein by western blot analysis. Various whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with CLPP antibody , diluted by 1:500. 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Mouse Un-conjugated ELISA, IHC, IHC (p), WB 100 μg Log in to see 11 to 14 Days
$537.17
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p), WB Human Liver (formalin-fixed, paraffin-embedded) stained with CLPP antibody ABIN351471 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. Anti-CLPP antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$537.17
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 11 to 14 Days
$484.00
Details

Top referenced anti-CLPP Antibodies

  1. Human Polyclonal CLPP Primary Antibody for ICC, IF - ABIN4299242 : Jenkinson, Rehman, Walsh, Clayton-Smith, Lee, Morell, Drummond, Khan, Naeem, Rauf, Billington, Schultz, Urquhart, Lee, Berry, Hanley, Mehta, Cilliers, Clayton, Kingston, Smith, Warner, Black, Trump et al.: Perrault syndrome is caused by recessive mutations in CLPP, encoding a mitochondrial ATP-dependent chambered protease. ... in American journal of human genetics 2013 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal CLPP Primary Antibody for IHC (p), ELISA - ABIN563560 : Kita, Suzuki, Ochi: Diphenylarsinic acid promotes degradation of glutaminase C by mitochondrial Lon protease. in The Journal of biological chemistry 2012 (PubMed)

  3. Human Polyclonal CLPP Primary Antibody for IHC (p), IHC - ABIN249797 : Bross, Andresen, Knudsen, Kruse, Gregersen: Human ClpP protease: cDNA sequence, tissue-specific expression and chromosomal assignment of the gene. in FEBS letters 1996 (PubMed)

More Antibodies against CLPP Interaction Partners

Mouse (Murine) ClpP Caseinolytic Peptidase, ATP-Dependent, Proteolytic Subunit Homolog (E. Coli) (CLPP) interaction partners

  1. Loss of the mitochondrial matrix protease CLPP results in a lean phenotype with improved glucose homeostasis. Whole-body CLPP-deficient mice are protected from diet-induced obesity and insulin resistance. CLPP ablation also leads to a decline in brown adipocytes function leaving mice unable to cope with a cold-induced stress due to non-functional adaptive thermogenesis.

  2. Our results show that absence of ClpP triggers compensatory responses in mice and suggest that ClpP might be dispensable for mammalian UPR(mt) initiation. Thus, we made an unexpected finding that deficiency of ClpP in mice is metabolically beneficial

  3. we demonstrate that a strong mitochondrial cardiomyopathy and diminished respiration due to DARS2 deficiency can be alleviated by the loss of CLPP, leading to an increased de novo synthesis of individual OXPHOS subunits.

  4. The authors present evidence that mammalian CLPP has an essential role in determining the rate of mitochondrial protein synthesis by regulating the level of mitoribosome assembly.

  5. Novel effects of ClpP on mitochondrial morphology, cell proliferation and protein translation pathways in muscle cells.

  6. Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.

  7. The correlative effect of Lon and ClpP upregulation on loss of mitochondrial Fe-S proteins during the progression of the disease may suggest that Fe-S proteins are potential targets of Lon and ClpP proteases in FRDA.

Human ClpP Caseinolytic Peptidase, ATP-Dependent, Proteolytic Subunit Homolog (E. Coli) (CLPP) interaction partners

  1. Mitochondrial overexpression of human ClpP protects HeLa cells from killing by cisplatin. Overexpression of human ClpP desensitizes cells to cisplatin.

  2. Autophagy compensates impaired energy metabolism in CLPXP-deficient Podospora anserina strains and extends healthspan.

  3. we demonstrate that a strong mitochondrial cardiomyopathy and diminished respiration due to DARS2 deficiency can be alleviated by the loss of CLPP, leading to an increased de novo synthesis of individual OXPHOS subunits.

  4. ere we present eight families affected by Perrault syndrome. In five families we identified novel or previously reported variants in HSD17B4, LARS2, CLPP and C10orf2

  5. Data suggest that tumors exploit ClpXP-directed proteostasis to maintain mitochondrial bioenergetics, buffer oxidative stress, and enable metastatic competence.

  6. Data indicate endopeptidase Clp (ClpP) mutation identified in two patients with Perrault syndrome type 3 in a Turkish family.

  7. ClpP proteases from E. coli, S. aureus, and human mitochondria exhibit preferences for certain amino acids in the P1, P2, and P3 positions .

  8. Optical trapping to assay single-molecule ClpXP unfolding and translocation of substrates consisting of domains with varying stabilities and sequences; find that ClpXP unfolds most domains by a single pathway, with kinetics that depend on the native fold and structural stability.

  9. Deletion of PaClpP, leads to an unexpected healthy phenotype and increased lifespan of the fungal ageing model organism Podospora anserina and This phenotype can be reverted by expression of human ClpP.

  10. Perrault syndrome is caused by recessive mutations in CLPP.

  11. the N-terminal peptide of ClpP is a structural component of the substrate translocation channel and may play an important functional role as well

  12. hClpX can regulate the appearance of hClpP peptidase activity in mitochondria and might affect the nature of the degradation products released during ATP-dependent proteolytic cycles

  13. We propose that decreased levels of mitochondrial proteases Lon and ClpP may allow heat shock protein 60 substrate proteins to go through more folding attempts

CLPP Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane.

Gene names and symbols associated with CLPP

  • caseinolytic mitochondrial matrix peptidase proteolytic subunit (CLPP) antibody
  • caseinolytic mitochondrial matrix peptidase proteolytic subunit L homeolog (clpp.L) antibody
  • caseinolytic mitochondrial matrix peptidase proteolytic subunit (clpp) antibody
  • ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (Clpp) antibody
  • caseinolytic mitochondrial matrix peptidase proteolytic subunit (Clpp) antibody
  • AU019820 antibody
  • CLPP antibody
  • D17Wsu160e antibody
  • MGC130667 antibody
  • PRLTS3 antibody

Protein level used designations for CLPP

ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) , endopeptidase Clp , ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog , putative ATP-dependent Clp protease proteolytic subunit, mitochondrial , caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog , caseinolytic protease, ATP-dependent, proteolytic subunit homolog , ATP-dependent protease ClpAP, proteolytic subunit, human , ClpP caseinolytic peptidase ATP-dependent, proteolytic subunit , ClpP caseinolytic protease, ATP-dependent, proteolytic subunit homolog , caseinolytic peptidase, ATP-dependent, proteolytic subunit

GENE ID SPECIES
455637 Pan troglodytes
496087 Xenopus laevis
699593 Macaca mulatta
100135748 Xenopus (Silurana) tropicalis
100161357 Acyrthosiphon pisum
53895 Mus musculus
8192 Homo sapiens
301117 Rattus norvegicus
535981 Bos taurus
611738 Canis lupus familiaris
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