anti-Collagen, Type IV, alpha 2 (COL4A2) Antibodies

COL4A2 encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Additionally we are shipping COL4a2 Proteins (7) and COL4a2 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
COL4A2 1284 P08572
COL4A2 12827 P08122
COL4A2 306628  
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Top anti-COL4a2 Antibodies at antibodies-online.com

Showing 10 out of 66 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), WB Anti-Collagen IV antibody, IHC(F) IHC(F): Rat Kidney Tissue Anti-Collagen IV antibody, Western blotting Lane 1: Rat Kidney Tissue Lysate Lane 2: Rat Lung Tissue Lysate 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of Collagen 4 alpha 2 expression in SHSY5Y (A), HEK293T (B), NIH3T3 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells, using Collagen IV alpha2 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using Collagen IV alpha2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB ABIN6268812 at 1/100 staining human Breast tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of Collagen IV 2 Antibody expression in Hela cells lysates. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB ABIN6274622 staining Hela cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibody. Western blot analysis of extracts from rat brain, using Collagen IV α2 Antibody. Lane 1 was treated with the antigen-specific peptide. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: Hela 5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated EIA, FACS, WB COL4A2 Antibody (N-term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. COL4A2 Antibody (N-term) western blot analysis in Hela cell line lysates (35µg/lane).This demonstrates the COL4A2 antibody detected the COL4A2 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB Western Blot (WB) analysis of SH-SY5Y 293T NIH-3T3 COLO205 cells using COL4A2 Polyclonal Antibody. 100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated FACS, WB COL4A2 Antibody (N-term) (ABIN655401) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the COL4A2 antibody detected the COL4A2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$493.17
Details

Top referenced anti-COL4a2 Antibodies

  1. Human Polyclonal COL4a2 Primary Antibody for ICC, IHC (fro) - ABIN3042317 : Chen, Wan, Xia, Guo, Wang, Liu, Li: Promoted regeneration of mature blood vessels by electrospun fibers with loaded multiple pDNA-calcium phosphate nanoparticles. in European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fu?r Pharmazeutische Verfahrenstechnik e.V 2013 (PubMed)
    Show all 13 Pubmed References

More Antibodies against COL4a2 Interaction Partners

Human Collagen, Type IV, alpha 2 (COL4A2) interaction partners

  1. Herein, we describe a large family of first-degree relatives affected by a novel heterozygous variant in COL4A2 (c.3490G.A).

  2. Data showed that Col4A2 can restrain triple-negative breast cancer (TNBC) cell lines MDA-MB-231 and MDA-MB-468 proliferation, migration, cell cycle, and ultimately lead to apoptosis. The data indicated that Col4A2 was significantly correlated with the proliferation and invasive potential of TNBC.

  3. In this study, the inhibitory effect of recombinant canstatin on tumour growth was investigated using a gastric cancer xenograft model.

  4. Genotype-phenotype correlations in pathology caused by COL4A1 and COL4A2 mutations have been summarized. (Review)

  5. These results of this study provide evidence that the mutation of COL4A2 is associated with lacunar ischemic stroke and deep intracerebral hemorrhage.

  6. COL4A2 expression is significantly upregulated in human masticatory mucosa during wound healing

  7. These results indicate that the CHD-related genetic variant at the COL4A2 locus affects COL4A2/COL4A1 expression, smooth muscle cells survival, and atherosclerotic plaque stability, providing a mechanistic explanation for the association between the genetic variant and CHD risk.

  8. Expression of miR-26a and miR-29a was significantly down regulated in leukoplakia and cancer tissues but up regulated in lichen planus tissues. Expression of target genes such as, ADAMTS7, ATP1B1, COL4A2, CPEB3, CDK6, DNMT3a and PI3KR1 was significantly down regulated in at least two of three disease types with respect to normal tissues.

  9. identified a novel COL4A2 (c.2399G>A, p.G800E, CCDS41907.1) mutation in an autosomal dominant family with porencephaly and ocular abnormalities

  10. No significant change in canstatin levels was observed between normotensive and pre-eclampsia patients.

  11. SMAD3 is a necessary factor for TGFbeta-mediated stimulation of mRNA and protein expression of type IV collagen genes in human vascular smooth muscle cells; it regulates expression of COL4a1 and COL4a2

  12. analysis of the unique AAB composition and chain register for a heterotrimeric type IV collagen model peptide COL4a1/COL4a2 containing a natural interruption site

  13. Studied the role of alpha1 and alpha2 chains of type IV collagen in UIP; found type IV collagen deposition in early fibrotic lesions of UIP may be implicated in refractory pathophysiology including migration of lesion fibroblasts via a FAK pathway.

  14. Reduction of COL4A2 expression by RNAI-mediated knockdown induces cell death. Finally, elevated Notch3 expression levels correlate with higher COL4A2 expression in human ovarian tumor specimens

  15. The expression of collagen type IV and its alpha chains (alpha1-6) was investigated in different endothelial cell culture systems in vitro qualitatively and quantitatively.

  16. An association was found between common variation in the COL4A2 gene and sporadic cerebral small vessel disease.

  17. Interleukin-1-induced changes in the glioblastoma secretome suggest its role in tumor progression.

  18. The whole exome sequencing showed no pathological mutations of COL4A1 and COL4A2 in fetal intraventricular hemorrhage

  19. Data indicate that the aberrantly methylated and expressed genes in cancer process including IRS1 and collagen-related genes COL4A1, COL4A2 and COL6A3.

  20. dominant COL4A2 mutations are a novel major risk factor for familial cerebrovascular disease, including porencephaly and small-vessel disease with reduced penetrance and variable phenotype, which might also be modified by other contributing factors.

Mouse (Murine) Collagen, Type IV, alpha 2 (COL4A2) interaction partners

  1. This work presents binding data consistent with a major role of 3-hydroxyproline in interactions of collagen IV with glycoprotein VI and nidogens 1 and 2.

  2. Mutations in murine Col4a1 and Col4a2 genes affected the balance between lung epithelial progenitors and differentiated cells. Mutations in Col4a1 derived from the vascular component were sufficient to cause defects in vascular development and the blood-gas barrier. Col4a1 and Col4a2 mutants displayed disrupted myofibroblast proliferation, differentiation and migration.

  3. COL4A1 and COL4A2 mutations are pleiotropic and cause a wide spectrum of disorders, including ocular dysgenesis, brain malformations and myopathy, of variable severity in both mice and humans.

  4. WT1 maintains testicular cord integrity by additively regulating the expression of basal lamina components Col4a1 and Col4a2 with SOX9.

  5. Data suggest that podocyte von Hippel-Lindau protein is required for normal maintenance of podocytes, basment membrane collagen {alpha}1{alpha}2{alpha}1(IV) deposition and ultrastructure, neuroglobin experssion and glomerular barrier properties.

  6. In murine embryos, collagen IV subunits alpha1(IV), alpha2(IV), alpha5(IV) and alpha6(IV) were detected in the basement membrane surrounding the lens vesicle, and they persisted in the capsule until adulthood.

  7. alpha2(IV)NC1 domain has a role in regulating tumor cell behavior

  8. The genetic, molecular, and phenotypic characterization of nine Col4a1 and three Col4a2 missense mutations recovered in random mutagenesis experiments in the mouse, are presented.

  9. Foxc2 plays an important role in the development of the mesenchyme through the regulation of MyoD gene expression but does not regulate Collagen type IV alpha 1 (Col4a1) or Col4a2

  10. These results indicate that SOX9 is essential for Col4a2 expression in mesangial cells and might be involved in the accumulation of alpha2(IV) collagen in experimental nephritis.

Cow (Bovine) Collagen, Type IV, alpha 2 (COL4A2) interaction partners

  1. Results describe the molecular mechanism underlying chain selection in the assembly of collagen IV, and the kinetics of interaction and assembly of the alpha1(IV) and alpha2(IV) NC1 domains.

COL4a2 (COL4A2) Antigen Profile

Protein Summary

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.

Gene names and symbols associated with COL4A2

  • collagen, type IV, alpha 2 L homeolog (col4a2.L) antibody
  • collagen type IV alpha 2 chain (COL4A2) antibody
  • collagen, type IV, alpha 2 (col4a2) antibody
  • collagen, type IV, alpha 2 (Col4a2) antibody
  • collagen type IV alpha 2 chain (Col4a2) antibody
  • Col4a-2 antibody
  • col4a2-a antibody
  • ICH antibody
  • POREN2 antibody
  • zCanstatin antibody

Protein level used designations for COL4A2

collagen, type IV, alpha 2 , collagen alpha2(IV) , collagen type IV alpha 2 chain , alpha 2 type IV collagen , type IV collagen alpha 2 chain , collagen alpha-2(IV) chain-like , canstatin , collagen alpha-2(IV) chain , procollagen, type IV, alpha 2 , alpha-2 collagen type IV

GENE ID SPECIES
373763 Xenopus laevis
403843 Canis lupus familiaris
418752 Gallus gallus
452661 Pan troglodytes
553355 Danio rerio
100153454 Sus scrofa
100429807 Macaca mulatta
100486079 Xenopus (Silurana) tropicalis
1284 Homo sapiens
12827 Mus musculus
306628 Rattus norvegicus
508632 Bos taurus
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