anti-Collagen, Type IV, alpha 4 (Col4A4) Antibodies

Col4A4 encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Additionally we are shipping Col4a4 Proteins (3) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Col4A4 1286 P53420
Col4A4 12829 Q9QZR9
Anti-Rat Col4A4 Col4A4 301562  
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Top anti-Col4a4 Antibodies at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Collagen IV alpha4 Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of COS7 cells, using Collagen IV alpha4 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Goat Un-conjugated ELISA   100 μg Log in to see 6 to 7 Days
$291.53
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, IHC (p) 100 μL Log in to see 11 to 14 Days
$493.17
Details
Human Rabbit Un-conjugated ELISA, IF, IHC   100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 11 to 14 Days
$375.83
Details
Human Rabbit Un-conjugated ELISA, IF, IHC (p) Immunohistochemistry analysis of paraffin-embedded human brain tissue using COL4A4 polyclonal antibody . Peptide Immunofluorescence analysis of COS-7 cells, using COL4A4 polyclonal antibody . Peptide 100 μg Log in to see 11 to 12 Days
$367.62
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μL Log in to see 6 to 7 Days
$351.11
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Used in DAB staining on fromalin fixed paraffin- embedded kidney tissue 100 μg Log in to see 15 to 18 Days
$350.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μg Log in to see 11 to 14 Days
$522.50
Details

More Antibodies against Col4a4 Interaction Partners

Human Collagen, Type IV, alpha 4 (Col4A4) interaction partners

  1. Results showed that COL4A4 c.1471C>T and COL4A3 c.3418 + 1G>T variants in cis are pathogenic and co-segregate with the benign familial hematuria. This result suggests that COL4A3 and COL4A4 digenic mutations in cis mimicking an autosomal dominant inheritance should be considered as a novel inheritance pattern of benign familial hematuria.

  2. COL4A mutations comprise a frequent cause of Familial microscopic hematuria.

  3. Three collagen type IV alpha 4 chain (COL4A4) heterozygous mutations that lead to 3 different collagen type IV kidney disease phenotypes, manifesting as Thin basement membrane nephropathy (TBMN), autosomal dominant Alport syndrome (ADAS), and focal segmental glomerulosclerosis (FSGS).

  4. For mutation screening, all exons of COL4A3 and COL4A4 genes were polymerase chain reaction-amplified and direct sequenced from genomic DNA, and the mutations were analyzed by comparing with members in this family, 100 ethnicitymatched controls and the sequence of COL4A3 and COL4A4 genes from GenBank. A novel mutation determining a nucleotide change was found, i.e. c.4195 A>T (p.Met1399Leu) at 44th exon of COL4A4 gene.

  5. Two families showed COL4A3/A4 mutations in cis, mimicking an autosomal dominant inheritance with a more severe phenotype and one showed COL4A3/A4 mutations in trans, mimicking an autosomal recessive inheritance with a less severe phenotype. In a fourth family, a de novo mutation (COL4A5) combined with an inherited mutation (COL4A3) triggered a more severe phenotype

  6. Alport syndrome is the result of mutations in any of three type IV collagen genes, COL4A3, COL4A4, or COL4A5. Because the three collagen chains form heterotrimers, there is an absence of all three proteins in the basement membranes where they are expressed. (Review)

  7. These findings indicate that the heterozygous mutations in COL4A3 or COL4A4 may cause ESRD on their own, although secondary factors, such as environmental factors or unknown genetic changes, might also contribute to the phenotype of kidney disease in patients with ADAS.

  8. mutations in COL4A3, COL4A4, and COL4A5 in Chinese patients with Alport Syndrome

  9. This finding broadens mutation spectrum of the COL4A4 gene and extends the phenotypic spectrum of collagen IV nephropathies.

  10. A novel frameshift mutation, c.3213delA (p.Gly1072GlufsFNx0169) in the COL4A4 gene, was identified in the Chinese pedigree with autosomal dominant Alport syndrome

  11. we describe a novel splicing mutation in COL4A4 that results in TBMN. This analysis increases our understanding of TBMN phenotype-genotype correlations, which should facilitate more accurate diagnosis and prenatal diagnosis of TBMN.

  12. New COL4A4 mutations among Portuguese patients with collagen IV-related nephropathies were identified in 8 unrelated families.

  13. Tetrastatin, the NC1 alpha 4 collagen IV domain level increases in pulmonary tumor extracts.

  14. we identified seven families with associated mutations in COL4A3 and COL4A4 genes and four families with associated mutations in COL4A4 and COL4A5. We did not find kindreds with digenic inheritance attributable to mutations in COL4A3 and COL4A5

  15. We found that 7 out of 70 families (10%) with familial focal segmental glomerulosclerosis in our cohort have rare variants in COL4A3 and COL4A4.

  16. The expression of collagen type IV and its alpha chains (alpha1-6) was investigated in different endothelial cell culture systems in vitro qualitatively and quantitatively.

  17. COL4A4 rs2229813 AA and GA+AA genotypes as well as the A allele play roles as risk factors for developing Keratoconus in our population.

  18. COL4A4 missense variants [c.G2636A (p.Gly879Glu) and c.C4715T (p.Pro1572Leu)] in family 1. COL4A4 c.G2636A, a novel variant, co-segregated with renal disease among maternal relatives.

  19. 9 mutation in COL4A4 associated with autosomal dominant Alport syndrome.

  20. We could hypothesize that mutations in COL4A3 and COL4A4 genes are not involved in keratoconus risk in Greek population.

Mouse (Murine) Collagen, Type IV, alpha 4 (Col4A4) interaction partners

  1. Report novel mouse model of Alport syndrome with accumulation abnormal collagen alpha3alpha4alpha5(IV) trimers in the glomerular basement membrane.

  2. the NC1 domain of {alpha}3 chain is critical for {alpha}3{alpha}4{alpha}5 type IV collagen network assembly

  3. Collagen alpha3(IV) nor alpha4(IV) were detected in the lens capsule 2 weeks postnatal.

  4. In kidney, when expressed onto Col4a3(-/-) background, human alpha3(IV) chain restored expression of and co-assembled with mouse alpha4 and alpha5(IV) chains at sites where human alpha3(IV) was expressed. All three chains required for network assembly.

  5. Alpha3(IV), alpha4(IV), and alpha5(IV) chains form a complex, which is a heterotrimer, and a defect in complex formation might be one of the molecular mechanisms underlying the pathogenesis of Alport syndrome.

Col4a4 (Col4A4) Antigen Profile

Protein Summary

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. This particular collagen IV subunit, however, is only found in a subset of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Mutations in this gene are associated with type II autosomal recessive Alport syndrome (hereditary glomerulonephropathy) and with familial benign hematuria (thin basement membrane disease). Two transcripts, differing only in their transcription start sites, have been identified for this gene and, as is common for collagen genes, multiple polyadenylation sites are found in the 3' UTR.

Gene names and symbols associated with Col4A4

  • collagen type IV alpha 4 chain (COL4A4) antibody
  • collagen, type IV, alpha 4 (col4a4) antibody
  • collagen, type IV, alpha 4 (Col4a4) antibody
  • collagen type IV alpha 4 chain (Col4a4) antibody
  • CA44 antibody
  • E130010M05Rik antibody
  • [a]4(IV) antibody

Protein level used designations for Col4A4

collagen alpha-4(IV) chain , collagen type IV alpha 4 chain , collagen, type IV, alpha 4 , alpha 4 type IV collagen , type IV collagen alpha 4 chain , collagen alpha-4(IV) chain-like , Collagen IV, alpha-4 polypeptide , collagen of basement membrane, alpha-4 chain , procollagen, type IV, alpha 4 , alpha type IV collagen basement membrane

GENE ID SPECIES
403841 Canis lupus familiaris
424799 Gallus gallus
459986 Pan troglodytes
554270 Danio rerio
708287 Macaca mulatta
100073948 Ornithorhynchus anatinus
100388461 Callithrix jacchus
100443710 Pongo abelii
100478914 Ailuropoda melanoleuca
100598507 Nomascus leucogenys
100621403 Sus scrofa
1286 Homo sapiens
12829 Mus musculus
301562 Rattus norvegicus
407107 Bos taurus
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