anti-Crystallin, alpha B (CRYAB) Antibodies

Human Crystallin, alpha B (CRYAB) interaction partners

1. A report of a novel 44 kDa protein which is most likely a covalently linked HspB5 dimer.

2. Data indicates that alterations in the part of the N-terminal region proximal to the core domain do not drastically affect the oligomerisation of alphaB-crystallin, reinforcing the robustness of alphaB-crystallin in functioning as a molecular chaperone.

3. HSPB5 engages multiple states of a destabilized client to enhance chaperone activity in a stress-dependent manner

4. chaperone alphaB-crystallin (CRYAB) is a MYOC-binding partner and that co-expression of these two proteins increases protein aggregates.

5. alphaB-crystallin mutants carrying point substitutions in the C-terminal domain

6. Heparan sulfate mediates cell uptake of alphaB-crystallin fused to the glycoprotein C cell penetration peptide

7. Our findings suggest that serum level of miR-491 has potential as a biomarker for predicting OS progression and prognosis of OS patients. miR-491 exerts its role by directly targeting alphaB-crystallin (CRYAB) in OS.

8. A missense mutation (p.D109G) in CRYAB causes restrictive cardiomyopathy (RCM).

9. Using a combination of co-sedimentation centrifugation, viscometric assays and electron microscopy of negatively stained filaments to analyse the in vitro assembly of desmin filaments, this study shows that the binding of CRYAB to desmin is subject to its assembly status, to the subunit organization within filaments formed and to the integrity of the C-terminal tail domain of desmin.

10. Overexpression of both HSPB5 and Hsp27 significantly reduced the intracellular aggregation of alpha-synuclein.

11. Glutathione-S-transferase - HspB1 fusion protein prevents more aggregation of malate dehydrogenase compared to glutathione-S-transferase -HspB5 fusion protein and wild type HspB1.

12. Mechanistic studies revealed KLF4 specifically bound the promoter of CRYAB and upregulated CRYAB expression in human osteosarcoma cells.

13. mRNA levels of HSP family members (HSP70B', HSP72, HSP40/DNAJ, and HSP20/CRYAB) are upregulated by the intracellular MMP3 overload.

14. HspB5 maybe trigger the epithelial-mesenchymal transition in colorectal cancer (CRC) by activating the ERK signaling pathway. It is a potential tumor biomarker for CRC diagnosis and prognosis.

15. The CLN6 is not only a molecular entity of the anti-aggregate activity conferred by the ER manipulation using TMalphaBC, but also serves as a potential target of therapeutic interventions.

16. Results demonstrated that CRYAA rs7278468 and CRYAB rs370803064/rs387907338 are correlated with the risk and clinicopathological features of children suffering from congenital cataract.

17. A missense mutation in alpha B-crystallin that changes proline 20 to an arginine leads to diminished anti-apoptotic activity compared with the native protein.

18. phosphorylation finely regulates the chaperone activity of CRYAB with multipass TMPs and suggest a pivotal role for S59 in this process

19. This work examines the molecular mechanism by which two canonical sHsps, alphaB-crystallin (alphaB-c) and Hsp27, interact with aggregation-prone alpha-syn to prevent its aggregation in vitro Both sHsps are very effective inhibitors of alpha-syn aggregation

Mouse (Murine) Crystallin, alpha B (CRYAB) interaction partners

1. results reveal a novel function for extracellular CRYAB in the regulation of neuroinflammation; targeting extracellular CRYAB-modulated neuroinflammation is a potential therapeutic intervention for multiple sclerosis

2. chaperone alphaB-crystallin (CRYAB) is a MYOC-binding partner and that co-expression of these two proteins increases protein aggregates.

3. Ectopic UAP56 upregulated HSF4-controlled HSP25 and alpha B-crystallin proteins expression, while knocking down UAP56 by shRNA reversed it.

4. The neuroprotective properties of alpha-crystallin B further demonstrate the potential importance of crystallin proteins in developing therapeutic options for glaucoma.

5. findings offer additional insight into the early transcriptional changes caused by Cryaa and Cryab mutations associated with autosomal dominant cataracts, and indicate that the transcript levels of certain genes are affected by the expression of mutant alpha-crystallin in vivo

6. It plays a protective and beneficial role in the aging PNS.

7. desmin and alphaBeta-crystallin are localized at sarcoplasmic reticulum (SR)-mitochondria-associated membranes (MAMs), where they interact with VDAC, Mic60 - the core component of mitochondrial contact site and cristae organizing system (MICOS) complex - and ATP synthase, suggesting that these associations could be crucial in mitoprotection at different levels.

8. this study shows the microglia clusters emerging during experimental autoimmune encephalomyelitis are associated with axonal damage and oligodendrocytes expressing heat-shock protein B5, but not lymphocytes

9. This study demonstrated that HspB5 mRNA localization in myelin-enriched white and gray matter

10. alphaB-crystallin is an important regulator of epithelial-mesenchymal transition, acting as a molecular chaperone for SMAD4 and as its potential therapeutic target for preventing subretinal fibrosis development in neovascular age-related macular degeneration

11. It is a non-Hsp gene, which is essential for HSF1-mediated maintenance of whole body homeostasis.

12. A previously unrecognized link between c-Jun and Nrf2 transcription factors and redox-induced CRYAB expression in muscle cells.

13. CryAB protects decidualization against stress conditions.

14. TNF-alpha-induced endothelial adhesion molecule expression is reduced in inflamed vessels of alphaB-crystallin deficient mice, and leukocyte rolling velocity and IkappaB levels are increased.

15. Study shows that overexpression of Bcl-2 is sufficient to reduce the levels and overall architecture of protein deposition in the transgenic CryABR120G/Bcl-2 hearts.

16. alphaB-crystallin is over-expressed in fibrotic lung tissue and favors TGF-beta1 pathway via its role in modulating the cellular localization of Smad4.

17. Data suggest that Cryab plays role in embryo implantation/decidualization; on day 5 of pregnancy when embryo implantation takes place, high level of Cryab mRNA is expressed in subluminal stroma surrounding the implanting blastocyst.

18. Alpha B-crystallin inhibits caspase 3 activation in cells primed for apoptosis by retinoblastoma protein inactivation.

19. data collectively demonstrate that alphaB crystallin provides critical protection of mitochondrial function during endoplasmic reticulum stress-induced retinal pigment epithelial apoptosis

20. astrocytic DRD2 activation normally suppresses neuroinflammation in the central nervous system through a CRYAB-dependent mechanism

Cow (Bovine) Crystallin, alpha B (CRYAB) interaction partners

1. analysis of the structural, molecular and spectroscopic changes in alpha-crystallin protein as it slowly denatures due to aggregation induced by non-enzymatic glycation

2. The alphaB-crystallin content of bovine type I muscle fibers is quantitatively similar to that in the predominantly type I fibers of rat soleus muscle.

3. These results show that between pH 7 and 10 the protein undergoes a reversible thermal transition.

4. alpha-crystallin is characterized by homogeneous distribution of scattering density in the domains inaccessible for water penetration

5. In the presence of alpha-crystallin or GroEL the kinetic of GAPDH aggregation is changed from the diffusion-limited cluster-cluster aggregation to the reaction-limited cluster-cluster aggregation.

6. one of the functions of alphaB-crystallin is to bind microtubules via microtubule binding proteins and to give the MTs resistance to disassembly

7. The study provides evidence for the regulation of the chaperone activity of alphaB-crystallin by phosphorylation and indicates that this may play an important role in alleviating the pathogenic effects associated with protein conformational diseases.

8. analysis of alpha-crystallin assisted refolding of enzyme substrates

9. The results are consistent with the hypothesis that short-range, weak, attractive interactions between alpha- and gamma-crystallins are necessary for maximum transparency of the lens.

Pig (Porcine) Crystallin, alpha B (CRYAB) interaction partners

1. This study clearly demonstrated that both the length and electrostatic charge of the COOH-terminal segment play crucial roles in governing the structural stability and chaperone activity of alphaB-crystallin.

Zebrafish Crystallin, alpha B (CRYAB) interaction partners

1. alphaB-crystallin has a role in stress tolerance of the heart presumably through the proteostasis network; it also has a critical role through chaperone activity in the maintenance of lens transparency

2. Zebrafish crystallin alpha B a encode activated chaperones.