anti-Crystallin, alpha B (CRYAB) Antibodies

Human Crystallin, alpha B (CRYAB) interaction partners

1. Using a combination of co-sedimentation centrifugation, viscometric assays and electron microscopy of negatively stained filaments to analyse the in vitro assembly of desmin (show DES Antibodies) filaments, this study shows that the binding of CRYAB to desmin (show DES Antibodies) is subject to its assembly status, to the subunit organization within filaments formed and to the integrity of the C-terminal tail domain of desmin (show DES Antibodies).

2. Overexpression of both HSPB5 and Hsp27 significantly reduced the intracellular aggregation of alpha-synuclein.

3. Glutathione-S-transferase (show GSTa2 Antibodies) - HspB1 (show HSPB1 Antibodies) fusion protein prevents more aggregation of malate dehydrogenase (show ME1 Antibodies) compared to glutathione-S-transferase (show GSTa2 Antibodies) -HspB5 fusion protein and wild type HspB1 (show HSPB1 Antibodies).

4. Mechanistic studies revealed KLF4 (show KLF4 Antibodies) specifically bound the promoter of CRYAB and upregulated CRYAB expression in human osteosarcoma cells.

5. mRNA levels of HSP family members (HSP70B', HSP72 (show HSPA1A Antibodies), HSP40/DNAJ (show DNAJB1 Antibodies), and HSP20 (show HSPB6 Antibodies)/CRYAB) are upregulated by the intracellular MMP3 (show MMP3 Antibodies) overload.

6. HspB5 maybe trigger the epithelial-mesenchymal transition in colorectal cancer (CRC (show CALR Antibodies)) by activating the ERK (show EPHB2 Antibodies) signaling pathway. It is a potential tumor biomarker for CRC (show CALR Antibodies) diagnosis and prognosis.

7. The CLN6 (show CLN6 Antibodies) is not only a molecular entity of the anti-aggregate activity conferred by the ER manipulation using TMalphaBC, but also serves as a potential target of therapeutic interventions.

8. Results demonstrated that CRYAA (show CRYAA Antibodies) rs7278468 and CRYAB rs370803064/rs387907338 are correlated with the risk and clinicopathological features of children suffering from congenital cataract.

9. A missense mutation in alpha B-crystallin that changes proline 20 to an arginine leads to diminished anti-apoptotic activity compared with the native protein.

10. phosphorylation finely regulates the chaperone activity of CRYAB with multipass TMPs and suggest a pivotal role for S59 in this process

Mouse (Murine) Crystallin, alpha B (CRYAB) interaction partners

1. findings offer additional insight into the early transcriptional changes caused by Cryaa (show CRYAA Antibodies) and Cryab mutations associated with autosomal dominant cataracts, and indicate that the transcript levels of certain genes are affected by the expression of mutant alpha-crystallin in vivo

2. desmin and alphaBeta-crystallin are localized at sarcoplasmic reticulum (SR)-mitochondria-associated membranes (MAMs), where they interact with VDAC, Mic60 - the core component of mitochondrial contact site and cristae organizing system (MICOS) complex - and ATP synthase, suggesting that these associations could be crucial in mitoprotection at different levels.

3. This study demonstrated that HspB5 mRNA localization in myelin-enriched white and gray matter

4. alphaB-crystallin is an important regulator of epithelial-mesenchymal transition, acting as a molecular chaperone (show HSP90AA1 Antibodies) for SMAD4 (show SMAD4 Antibodies) and as its potential therapeutic target for preventing subretinal fibrosis development in neovascular age-related macular degeneration

5. It is a non-Hsp gene, which is essential for HSF1 (show HSF1 Antibodies)-mediated maintenance of whole body homeostasis.

6. A previously unrecognized link between c-Jun (show JUN Antibodies) and Nrf2 (show NFE2L2 Antibodies) transcription factors and redox-induced CRYAB expression in muscle cells.

7. CryAB protects decidualization against stress conditions.

8. TNF-alpha (show TNF Antibodies)-induced endothelial adhesion molecule (show NCAM1 Antibodies) expression is reduced in inflamed vessels of alphaB-crystallin deficient mice, and leukocyte rolling velocity and IkappaB levels are increased.

9. Study shows that overexpression of Bcl-2 (show BCL2 Antibodies) is sufficient to reduce the levels and overall architecture of protein deposition in the transgenic CryABR120G/Bcl-2 (show BCL2 Antibodies) hearts.

10. alphaB-crystallin is over-expressed in fibrotic lung tissue and favors TGF-beta1 (show TGFB1 Antibodies) pathway via its role in modulating the cellular localization of Smad4 (show SMAD4 Antibodies).

Cow (Bovine) Crystallin, alpha B (CRYAB) interaction partners

1. The alphaB-crystallin content of bovine type I muscle fibers is quantitatively similar to that in the predominantly type I fibers of rat soleus muscle.

2. In the presence of alpha-crystallin or GroEL (show GroEL Antibodies) the kinetic of GAPDH (show GAPDH Antibodies) aggregation is changed from the diffusion-limited cluster-cluster aggregation to the reaction-limited cluster-cluster aggregation.

3. one of the functions of alphaB-crystallin is to bind microtubules via microtubule binding proteins and to give the MTs (show NEU2 Antibodies) resistance to disassembly

4. The study provides evidence for the regulation of the chaperone activity of alphaB-crystallin by phosphorylation and indicates that this may play an important role in alleviating the pathogenic effects associated with protein conformational diseases.

Pig (Porcine) Crystallin, alpha B (CRYAB) interaction partners

1. This study clearly demonstrated that both the length and electrostatic charge of the COOH-terminal segment play crucial roles in governing the structural stability and chaperone activity of alphaB-crystallin.