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Crystallin, alpha B Products

(Crystallin, alpha B (CRYAB))

Categories

Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families\; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone\; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits\; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed\; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases\; a missense mutation cosegregated in a family with a desmin-related myopathy. [provided by RefSeq, Jul 2008].

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Featured Crystallin, alpha B Categories

Crystallin, alpha B Antibodies

High quality antibodies with extensive validation data.

Crystallin, alpha B ELISA Kits

Reliable ELISA kits for a wide range of species.

Crystallin, alpha B Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Crystallin, alpha B Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, ICC, IP
Validations
  • (8)
Cat. No. ABIN7435256
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IHC (p), IP, FACS
Validations
  • (13)
Cat. No. ABIN1497647
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Rat
Application WB, IHC, StM
Validations
  • (5)
Cat. No. ABIN6939187
Quantity 100 μg
Datasheet Datasheet

Recommended Crystallin, alpha B ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966147
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966146
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955122
Quantity 96 tests
Datasheet Datasheet

Recommended Crystallin, alpha B Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1350424
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7319198
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7396997
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Crystallin, alpha B products

Anders, Liu, Mann, Teister, Lauzi, Thanos, Grus, Pfeiffer, Prokosch: "The Small Heat Shock Protein α-Crystallin B Shows Neuroprotective Properties in a Glaucoma Animal Model." in: International journal of molecular sciences, Vol. 18, Issue 11, (2018) (PubMed).

Piccolella, Crippa, Cristofani, Rusmini, Galbiati, Cicardi, Meroni, Ferri, Morelli, Carra, Messi, Poletti: "The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells." in: Oncotarget, Vol. 8, Issue 6, pp. 10400-10415, (2018) (PubMed).

Bolton, Montastier, Carayol, Bonnel, Mir, Marques, Astrup, Saris, Iacovoni, Villa-Vialaneix, Valsesia, Langin, Viguerie: "Molecular Biomarkers for Weight Control in Obese Individuals Subjected to a Multiphase Dietary Intervention." in: The Journal of clinical endocrinology and metabolism, Vol. 102, Issue 8, pp. 2751-2761, (2017) (PubMed).

Dong, Dong, Kase, Ando, Fukuhara, Kinoshita, Inafuku, Tagawa, Ishizuka, Saito, Murata, Kanda, Noda, Ishida: "Phosphorylation of alphaB-crystallin in epiretinal membrane of human proliferative diabetic retinopathy." in: International journal of ophthalmology, Vol. 9, Issue 8, pp. 1100-5, (2016) (PubMed).

Gangalum, Bhat, Kohan, Bhat: "Inhibition of the Expression of the Small Heat Shock Protein αB-Crystallin Inhibits Exosome Secretion in Human Retinal Pigment Epithelial Cells in Culture." in: The Journal of biological chemistry, Vol. 291, Issue 25, pp. 12930-42, (2016) (PubMed).

Liu, Chen, Zheng, Qin, Liang, Feng, Wu: "Differences in atrial fibrillation‑associated proteins between the left and right atrial appendages from patients with rheumatic mitral valve disease: A comparative proteomic analysis." in: Molecular medicine reports, Vol. 14, Issue 5, pp. 4232-4242, (2016) (PubMed).

Baba, Oshitari, Yamamoto: "Level of vitreous alpha-B crystallin in eyes with rhegmatogenous retinal detachment." in: Graefe's archive for clinical and experimental ophthalmology, Vol. 253, Issue 8, pp. 1251-4, (2015) (PubMed).

Kötter, Unger, Hamdani, Lang, Vorgerd, Nagel-Steger, Linke: "Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins." in: The Journal of cell biology, Vol. 204, Issue 2, pp. 187-202, (2014) (PubMed).

Akkad, Corpeno, Larsson: "Masseter muscle myofibrillar protein synthesis and degradation in an experimental critical illness myopathy model." in: PLoS ONE, Vol. 9, Issue 4, pp. e92622, (2014) (PubMed).

Banerjee Mustafi, Grose, Zhang, Pratt, Sadoshima, Christians, Benjamin: "Aggregate-prone R120GCRYAB triggers multifaceted modifications of the thioredoxin system." in: Antioxidants & redox signaling, Vol. 20, Issue 18, pp. 2891-906, (2014) (PubMed).

Synonyms and alternative names related to Crystallin, alpha B

crystallin alpha B (CRYAB), crystallin, alpha B (Cryab), hypothetical protein (ZK1128.7), crystallin alpha B (Cryab), crystallin, alpha B, a (cryaba), crystallin, alpha B, b (cryabb), AACRYA, CMD1II, Crya-2, CRYA2, Crya2, CRYAB, cryab, cryab2, CTPP2, CTRCT16, HSPB5, HspB5, MFM2, wu:fe37f08, zgc:91937

Protein level used designations for Crystallin, alpha B

  • alpha-crystallin B chain
  • heat shock protein beta-5
  • heat-shock 20 kD like-protein
  • renal carcinoma antigen NY-REN-27
  • rosenthal fiber component
  • P23
  • alpha B-crystallin
  • alpha(B)-crystallin
  • crystallin, alpha 2
  • Crystallin, alpha polypeptide 2
  • hypothetical protein
  • crystallin, alpha B
  • alpha B crystallin
  • alpha-B-crystallin
  • alphaB-crystallin
  • crystallin, alpha polypeptide 2
  • Alpha(B)-crystallin
  • Alpha-crystallin B chain
  • hspb5
  • hspb5a
  • alphaB2-crystallin
  • crystallin alphaB-b
  • crystallin, alpha B2
  • fe37f08
  • hspb5b
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