anti-Cullin 4B (CUL4B) Antibodies

CUL4B is a member of the cullin family. Additionally we are shipping Cullin 4B Proteins (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CUL4B 8450 Q13620
CUL4B 72584 A2A432
CUL4B 302502  
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Top anti-Cullin 4B Antibodies at antibodies-online.com

Showing 10 out of 130 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Rat Brain, antibody was diluted at 1:100. 100 μL Available
$363.46
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-Cullin 4B antibody, IHC(P) IHC(P): Zebrafish Body Tissue Anti-Cullin 4B antibody, Western blotting WB: Rat Lung Tissue Lysate 100 μg 4 to 6 Days
$280.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Cul4b AntibodyTitration: 1.0 µg/mL  Positive Control: Mouse Heart 100 μL 2 to 3 Days
$289.00
Details
Dog Mouse Un-conjugated IHC, IHC (p), WB 100 μL 11 to 14 Days
$522.50
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Human Mouse Un-conjugated WB 100 μL 11 to 14 Days
$522.50
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Dog Mouse Un-conjugated WB 100 μL 11 to 14 Days
$522.50
Details
Human Rabbit Un-conjugated IF/ICC, IHC, WB Western blot analysis of extracts of various cell lines, using CUL4B antibody (ABIN5973129) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded rat liver using CUL4B antibody (ABIN5973129) at dilution of 1/200 (40x lens). 100 μL 11 to 16 Days
$426.40
Details
Human Rabbit Un-conjugated ELISA, IHC, WB ABIN6269584 at 1/100 staining human kidney tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of Phospho-CUL4B(Thr48) in lysates of 293T?, using Phospho-CUL4B(Thr48) Antibody(ABIN6269584). 100 μL 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated IF, IHC, WB 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated WB Western blot analysis of CUL4B Antibody (Center) Pab (ABIN1881241) pre-incubated without(lane 1) and with(lane 2) blocking peptide in Hela cell line lysate. CUL4B Antibody (Center) (arrow) was detected using the purified Pab. Anti-CUL4B Antibody (Center)at 1:2000 dilution + human testis lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 104 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:2000 400 μL 10 to 11 Days
$385.00
Details

Top referenced anti-Cullin 4B Antibodies

  1. Human Polyclonal CUL4B Primary Antibody for WB - ABIN1881241 : Aggarwal, Vaites, Kim, Mellert, Gurung, Nakagawa, Herlyn, Hua, Rustgi, McMahon, Diehl: Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. in Cancer cell 2010 (PubMed)
    Show all 5 Pubmed References

  2. Polyclonal CUL4B Primary Antibody for IHC (p), WB - ABIN540605 : Tarpey, Raymond, OMeara, Edkins, Teague, Butler, Dicks, Stevens, Tofts, Avis, Barthorpe, Buck, Cole, Gray, Halliday, Harrison, Hills, Jenkinson, Jones, Menzies, Mironenko, Perry, Raine, Richardson et al.: Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, ... in American journal of human genetics 2007 (PubMed)
    Show all 3 Pubmed References

More Antibodies against Cullin 4B Interaction Partners

Human Cullin 4B (CUL4B) interaction partners

  1. High CUL4B expression is associated with metastasis and proliferation in pancreatic cancer cells by inducing epithelial-mesenchymal transition.

  2. Taken together, the findings of this study suggest that the miR381/miR489mediated expression of CUL4B modulates the proliferation and invasion of GC cells via the Wnt/betacatenin pathway, which indicates that the miR381/miR489CUL4B axis is critical in the control of GC tumourigenesis.

  3. High CUL4B expression promotes gastric cancer invasion and metastasis.

  4. Results show that CUL4B is highly expressed in pancreatic cancer cells and inversely correlated with miR-300 expression which activate the Wnt/beta-catenin signaling pathway and further stimulating EMT, thus promoting proliferation and migration but suppressing apoptosis of pancreatic cancer cells.

  5. The CUL4B interacts with WD-40 proteins through the adaptor protein DNA damage-binding protein 1 (DDB1) to target substrates for ubiquitylation.

  6. This study found that microRNA-194 (miR-194) and CUL4B protein were inversely correlated in cancer specimens and demonstrated that miR-194 could downregulate CUL4B by directly targeting its 3'-UTR.

  7. findings revealed that CUL4A and CUL4B are differentially associated with etiologic factors for pulmonary malignancies and are independent prognostic markers for the survival of distinct lung cancer subtypes

  8. CUL4B regulates protein turnover and homeostasis in response to dopamine stimulation.

  9. CUL4B protein levels in human subcutaneous adipose tissue is negatively correlated with body mass index.

  10. these results suggest that knockdown of CUL4B inhibited the proliferation and invasion through suppressing the Wnt/beta-catenin signaling pathway in NSCLC cells. Therefore, CUL4B may represent a novel therapeutic target for the treatment of NSCLC.

  11. these results showed that knockdown of CUL4B inhibit proliferation and promotes apoptosis of colorectal cancer cells through suppressing the Wnt/beta-catenin signaling pathway

  12. Our data are consistent with the idea that the CUL4A/B-DDB1-CRBN complex catalyses the polyubiquitination and thus controls the degradation of CLC-1 channels.

  13. FBXO44-mediated degradation of RGS2 protein uniquely depends on a Cul4B/DDB1 complex.

  14. results established a critical role of CUL4B in negatively regulating the p53-ROS positive feedback loop that drives cellular senescence

  15. Results demonstrated that CUL4B promotes cell proliferation and inhibits the apoptosis of osteosarcoma cells.

  16. Results show that CUL4A- and CUL4B-mediated polyubiquitination of gamma-tubulin for its degradation.

  17. Data show that CUL4B variants are associated with a wide range of cerebral malformations and suggest an important role in brain through its interaction with WDR62, a protein in which variants were identified in patients with cerebral malformations.

  18. Cullin4B-Ring E3 ligase complex (CRL4B) is physically associated with PRC2. CRL4B possesses an intrinsic transcription repressive activity by promoting H2AK119 monoubiquitination. CUL4B promotes cancer cell proliferation, invasion, and tumorigenesis in vitro and in vivo.

  19. CUL4B can up-regulate Wnt/beta-catenin signalling in human HCC through transcriptionally repressing Wnt antagonists and thus contributes to the malignancy of HCC.

  20. The intellectual disability phenotype is caused by aberrant splicing and removal of intron 7 from CUL4B gene primary transcript.

Mouse (Murine) Cullin 4B (CUL4B) interaction partners

  1. CUL4B level mediates HOX gene expression via histone H2A ubiquitination. Aberrant CUL4B-mediated H2AK119ub1 level may be a risk factor for neural tube defects.

  2. High CUL4B expression promotes gastric cancer invasion and metastasis.

  3. A cullin 4B-RING E3 ligase complex fine-tunes pancreatic delta cell paracrine interactions

  4. Adipocyte-specific Cul4b knockout (AKO) mice being fed a high-fat diet exhibited increased body fat accumulation that was mediated by increased adipogenesis. However, AKO mice showed improved metabolic phenotypes, including increased insulin sensitivity and glucose tolerance. Correspondingly, there was a decreased inflammatory response in adipose tissues of AKO mice.

  5. CUL4B as a key regulator of post-meiotic sperm morphogenesis

  6. CUL4B links two distinct spermatogenetic processes to a single E3 ligase, highlighting the significance of ubiquitin modification during spermatogenesis.

  7. results demonstrate a critical role of CUL4B in hepatocarcinogenesis in mice

  8. Ptgds is targeted and repressed by the CUL4B/PRC2 complex.

  9. FBXO44-mediated degradation of RGS2 protein uniquely depends on a Cul4B/DDB1 complex.

  10. CUL4B knockdown alleviated in vivo tumorigenesis in glioma xenograft nude mice.

  11. Data indicate a role of cullin family, CUL4B, in the immune system.

  12. Data indicate that in Cul4b-deficient embryonic fibroblasts showed Jab1 accumulation.

  13. Cul4b mutant mouse showed decrease in the number of parvalbumin-positive neurons and altered dendritic properties.

  14. Epiblast-specific deletion of Cul4b prevented embryonic lethality and gave rise to viable Cul4b null mice.

  15. Cul4b is essential for the development of extra-embryonic tissues, but is dispensable for embryogenesis itself.

  16. Cul4b null mouse embryos show severe developmental arrest and usually die before embryonic day 9.5. The placentas in Cul4b heterozygotes were disorganized and were impaired in vascularization, which may contribute to the developmental delay.

  17. study concludes that Cul4B licenses the tristetraprolin (TTP) containing TNF-alpha messenger ribonucleoprotein for loading onto polysomes, and reduction of Cul4B expression shunts the messenger ribonucleoproteins into the degradative pathway

  18. The cloning and expression of amino and carboxy-terminal halves of cullin4B in mouse PCC4 cells is reported.

  19. Plays a conserved role in the regulation of beta-catenin levels.

Zebrafish Cullin 4B (CUL4B) interaction partners

  1. Results show that cul4a but not cul4b is required for the expression of tbx5a, an essential transcription factor in heart and limb development.

Cullin 4B (CUL4B) Antigen Profile

Protein Summary

This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with anti-Cullin 4B (CUL4B) Antibodies

  • cullin 4B (CUL4B) antibody
  • cullin 4B (Cul4b) antibody
  • cullin 4B (cul4b) antibody
  • cullin 4B S homeolog (cul4b.S) antibody
  • cullin 4B (Tb927.3.1290) antibody
  • 2700050M05Rik antibody
  • AA409770 antibody
  • CUL-4B antibody
  • im:7140950 antibody
  • im:7150765 antibody
  • MGC115611 antibody
  • mKIAA0695 antibody
  • mrxhf2 antibody
  • MRXS15 antibody
  • mrxsc antibody
  • RGD1564494 antibody
  • sfm2 antibody
  • Tb03.1J15.620 antibody

Protein level used designations for anti-Cullin 4B (CUL4B) Antibodies

CUL-4B , cullin-4B , cullin 4B , cullin-4B-like

GENE ID SPECIES
8450 Homo sapiens
72584 Mus musculus
302502 Rattus norvegicus
422364 Gallus gallus
492102 Canis lupus familiaris
539668 Bos taurus
560313 Danio rerio
696410 Macaca mulatta
735163 Xenopus laevis
3656065 Trypanosoma brucei brucei strain 927/4 GUTat10.1
100033938 Equus caballus
100079138 Ornithorhynchus anatinus
100151714 Xenopus (Silurana) tropicalis
100194954 Salmo salar
100351102 Oryctolagus cuniculus
100394843 Callithrix jacchus
100475326 Ailuropoda melanoleuca
100513454 Sus scrofa
100542698 Meleagris gallopavo
100564485 Anolis carolinensis
100592746 Nomascus leucogenys
100714185 Cavia porcellus
101113913 Ovis aries musimon
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