Cullin 4B antibody (AA 250-278)

Catalog No. ABIN1881241

Product Details anti-Cullin 4B Antibody

Target: Cullin 4B (CUL4B)

Binding Specificity: AA 250-278

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cullin 4B antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CUL4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-278 amino acids from the Central region of human CUL4B.

Clone: RB42521

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-Cullin 4B antibody (ABIN1881241)

Aggarwal, Vaites, Kim, Mellert, Gurung, Nakagawa, Herlyn, Hua, Rustgi, McMahon, Diehl: "Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase." in: Cancer cell, Vol. 18, Issue 4, pp. 329-40, (2010) (PubMed).

Kerzendorfer, Whibley, Carpenter, Outwin, Chiang, Turner, Schwartz, El-Khamisy, Raymond, ODriscoll: "Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks." in: Human molecular genetics, Vol. 19, Issue 7, pp. 1324-34, (2010) (PubMed).

Gascoin-Lachambre, Buffat, Rebourcet, Chelbi, Rigourd, Mondon, Mignot, Legras, Simeoni, Vaiman, Barbaux: "Cullins in human intra-uterine growth restriction: expressional and epigenetic alterations." in: Placenta, Vol. 31, Issue 2, pp. 151-7, (2010) (PubMed).

Badura-Stronka, Jamsheer, Materna-Kiryluk, Sowińska, Kiryluk, Budny, Latos-Bieleńska: "A novel nonsense mutation in CUL4B gene in three brothers with X-linked mental retardation syndrome." in: Clinical genetics, Vol. 77, Issue 2, pp. 141-4, (2010) (PubMed).

Abbas, Shibata, Park, Jha, Karnani, Dutta: "CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation." in: Molecular cell, Vol. 40, Issue 1, pp. 9-21, (2010) (PubMed).

Target Details for Cullin 4B

Target: Cullin 4B (CUL4B)

Alternative Name: CUL4B (CUL4B Products)

Synonyms: MRXHF2 antibody, MRXS15 antibody, MRXSC antibody, SFM2 antibody, 2700050M05Rik antibody, AA409770 antibody, CUL-4B antibody, mKIAA0695 antibody, RGD1564494 antibody, im:7140950 antibody, im:7150765 antibody, MGC115611 antibody, Tb03.1J15.620 antibody, sfm2 antibody, mrxsc antibody, mrxhf2 antibody, cullin 4B antibody, cullin 4B S homeolog antibody, CUL4B antibody, Cul4b antibody, cul4b antibody, cul4b.S antibody, Tb927.3.1290 antibody

Background: This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Molecular Weight: 103982

NCBI Accession: NP_001073341, NP_003579

UniProt: Q13620