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The protein encoded by CCNT2 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle.
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miR (show MLXIP Antibodies)-192 inhibits cell proliferation and induces G0/G1 cell cycle arrest in AML (show RUNX1 Antibodies) by regulating the expression of CCNT2.
the release of P-TEFb (show CCNT1 Antibodies) from the 7SK snRNP (show LSM2 Antibodies) led to increased synthesis of HEXIM1 (show HEXIM1 Antibodies) but not HEXIM2 (show HEXIM2 Antibodies)
interaction with pRb (show RB1 Antibodies)
CycT2 not only contains two domains that target rna polymerase II but this substrate recognition is necessary for its transcriptional activity via DNA
Data strengthen the hypothesis that Cyclin T2a plays a role in muscle differentiation, and propose PKNalpha (show PKN1 Antibodies) as a novel partner of Cyclin T2a in this process.
The results establish that cdk9 (show CDK9 Antibodies)/cyclin T2a-mediated coactivation of MyoD (show MYOD1 Antibodies) depends on serine 37 phosphorylation.
These results suggest that acetylation of CDK9 (show CDK9 Antibodies) is an important posttranslational modification that is involved in regulating P-TEFb (show CCNT1 Antibodies) transcriptional elongation function.
TAF7 interacts with the transcription factors, TFIIH and P-TEFb, resulting in the inhibition of their Pol II CTD kinase activities
The tripartite protein-RNA complex formation between Hexim (show HEXIM1 Antibodies), Cyclin T (show CCNT1 Antibodies) and 7SK snRNA, was analyzed.
both isoforms of Cyclin T2 are able to activate the myogenic program but Cyclin T2b has a predominant role, in particular during the latest stages.
miR (show MLXIP Antibodies)-15a inhibited muscle differentiation at least in part by targeting Ccnt2; roles in spermatogenesis.
activation of MyoD (show MYOD1 Antibodies)-dependent transcription by cdk9 (show CDK9 Antibodies)/cyclin T2
despite numerous matings of heterozygous mice, we observed no CycT2(-/-) embryos, pups, or adult mice. This early lethality could have resulted from decreased expression of critical genes
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.
, SDS-stable vimentin-bound DNA fragment HEF42VIM22
, cyclin T2a
, cyclin T2b
, subunit of positive elongation transcription factor b