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Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2\; MIM 116940) (Li et al., 2009 [PubMed 18060517]).[supplied by OMIM, May 2009].. Additionally we are shipping Cyclin Y Kits (17) and Cyclin Y Proteins (6) and many more products for this protein.
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Human Polyclonal Cyclin Y Primary Antibody for IHC, IHC (p) - ABIN4288911
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
CycY/Eip63E form a cyclin (show PCNA Antibodies)/Cdk (show CDK4 Antibodies) complex that is essential for several developmental processes.
findings revealed an unrecognized role of Caprin-2 (show CAPRIN2 Antibodies) in facilitating LRP5 (show LRP5 Antibodies)/6 constitutive phosphorylation at G2/M through forming a quaternary complex with CDK14 (show CDK14 Antibodies), Cyclin Y, and LRP5 (show LRP5 Antibodies)/6.
we believe that CCNY has biological effect in breast cancer (BC) development, and its inhibition via an RNA interference lentiviral system may provide a therapeutic option for BC
CCNY was significantly upregulated in ovarian cancer cell lines and tissues. Significant association was observed between CCNY expression and clinicopathological stage and lymph node metastasis. It significantly exacerbated proliferation, migration, and invasion of A2780 cells, in vitro and in nude mice. It significantly increased c-Myc (show MYC Antibodies), cyclin D1 (show CCND1 Antibodies), PFTK1 (show CDK14 Antibodies), ki67 (show MKI67 Antibodies), and OGT (show OGT Antibodies) protein expressions in xenograft tumor tissues.
Activation of PCTAIRE-1 (show CDK16 Antibodies) is mediated through interaction with the phosphorylated form of cyclin Y in complex with 14-3-3 (show YWHAQ Antibodies).
Our findings highlight a PFTK1 (show CDK14 Antibodies)-CCNY complex in activating noncanonical Wnt (show WNT2 Antibodies) signaling in HCC (show FAM126A Antibodies) cells.
Human cyclin Y (CCNY) is a phosphoprotein in vivo and phosphorylation of CCNY by CDK14 (show CDK14 Antibodies) triggers its ubiquitination and degradation.
Cyclin Y regulates the expression and membrane trafficing of PCTAIRE (show CDK16 Antibodies) kinases (PCTK). (Review)
CCNY (show CDK16 Antibodies)binding to CDK16 required a region upstream of the kinase domain and was found to be inhibited by phosphorylation of serine 153, a potential PKA phosphorylation site.
these results validated the role of CCNY as a clinically relevant human oncoprotein
CCNY might play an important role in glioma tumorigenisis.
Here we show that Cyclin Y-like 1 (Ccnyl1) and Cyclin Y (Ccny) have overlapping function and are crucial for mouse embryonic development and mammary stem/progenitor cell functions. Double knockout of Ccnys results in embryonic lethality at E16.5
these results provide a new link between CCNY and lipid metabolism in mice.
CDK16 (show CDK16 Antibodies) isolated from testis was unphosphorylated, interacted with CCNY, and exhibited kinase activity.
Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2\; MIM 116940) (Li et al., 2009
, drosophila cyclin Y
, cyclin box protein 1
, cyclin fold protein 1
, cyclin-box carrying protein 1