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The protein encoded by CDK10 belongs to the CDK subfamily of the Ser/Thr protein kinase family. Additionally we are shipping CDK10 Proteins (6) and and many more products for this protein.
Showing 10 out of 104 products:
Human Polyclonal CDK10 Primary Antibody for IHC (p), WB - ABIN391741
Leman, Magheli, Yong, Netto, Hinz, Getzenberg: Identification of nuclear structural protein alterations associated with seminomas. in Journal of cellular biochemistry 2009
Show all 12 Pubmed References
Human Polyclonal CDK10 Primary Antibody for ELISA, WB - ABIN541986
Iorns, Turner, Elliott, Syed, Garrone, Gasco, Tutt, Crook, Lord, Ashworth: Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer. in Cancer cell 2008
The present study illustrated that downregulation of CDK10 expression activated Snaildriven EMT and consequently promoted glioma metastasis, suggesting that CDK10 may serve as a potential molecular target for glioma therapy.
the results of the present study indicated that CDK10 expression may serve as a novel prognostic biomarker that holds therapeutic promise for gastric cancer.
The findings of this study indicate that CDK10 plays a role in the pathogenesis in colorectal cancer and may be a potential therapeutic target for treatment.
These findings underscore the importance of CDK10 for the regulation of ciliogenesis. CDK10 defect is likely associated with a new form of ciliopathy phenotype; additional patients may further validate this association
CDK10 Mutations are associated with Severe Growth Retardation, Spine Malformations, and Developmental Delays.
CDK10/CycM is a key regulator of actin dynamics and a suppressor of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling.
Down-regulated CDK10 expression frequently occurs in breast cancers and correlates with disease progression and poor survival
Results found that CDK10 mRNA expression was up-regulated in advanced breast neoplasm and positively correlated with C1orf63, which was consistent with the relationship of protein expression between C1orf63 and CDK10.
Data suggest that reactivation of CDK10 might be utilized as a novel epigenetic strategy for the treatment of nasopharyngeal carcinomas (NPC) patients.
CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome.
Data show that peptidyl-prolyl isomerase Pin1 silencing in SKBR-3 and MCF7 cells increased the cyclin-dependent kinase 10 (CDK10) expression.
CDK10 plays a crucial role in the growth and survivability of biliary tract cancer.
reduced Cdk10 expression is closely linked to hepatocellular carcinoma development and progression
CDK10 is not a target for aberrant DNA methylation in breast cancer.
Data indicate that peptidyl-prolyl isomerase Pin1(-/-) mouse embryonic fibroblasts (MEFs) showed higher cyclin-dependent kinase 10 (CDK10) expression than Pin1(+/+) MEFs.
Data show that murine cdk10 binds Ets2 transcription factors in vitro, does not show a direct involvement in the G2/M transition and, therefore, does not affect the proliferation rate of the cell lines analyzed.
Discusses PISSLRE, the human ortholog of mouse cyclin-dependent kinase 10.
cdk10 has roles in vertebrate development and a critical function in neurogenesis by modulation of raf1a expression
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene.
CDC2-related protein kinase
, cell division protein kinase 10
, cyclin-dependent kinase (CDC2-like) 10
, cyclin-dependent kinase related protein
, serine/threonine protein kinase PISSLRE
, serine/threonine-protein kinase PISSLRE
, cyclin dependent kinase 10
, PITSLRE subfamily protein kinase
, protein kinase, CMGC group
, cyclin-dependent kinase 10
, cell division protein kinase 10-like
, hypothetical protein