anti-Cystathionine-beta-Synthase (CBS) Antibodies

The protein encoded by CBS acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. Additionally we are shipping Cystathionine-beta-Synthase Kits (19) and Cystathionine-beta-Synthase Proteins (17) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CBS 24250 P32232
CBS 12411 Q91WT9
CBS 875 P35520
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Top anti-Cystathionine-beta-Synthase Antibodies at antibodies-online.com

Showing 10 out of 139 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IHC (p), IP, RNAi, ELISA, WB Immunoperoxidase of monoclonal antibody to CBS on formalin-fixed paraffin-embedded human hepatocellular carcinoma. [antibody concentration 3 ug/ml] CBS monoclonal antibody (M01), clone 3E1 Western Blot analysis of CBS expression in HeLa . 100 μg Log in to see 11 to 12 Days
$348.04
Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$249.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-CBS antibody, Western blotting Lane 1: SMMC Cell Lysate Lane 2: U87 Cell Lysate Lane 3: HELA Cell Lysate Lane 4: MM231 Cell Lysate Anti-CBS antibody, IHC(P) IHC(P): Human Liver Cancer Tissue 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- CBS antibody, Western blotting All lanes: Anti CBS  at 0.5ug/ml WB: Recombinant human CBS Protein 0.5ng Predicted bind size: 42KD Observed bind size: 42KD 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of CBS Antibody (Center) (ABIN390947) in mouse kidney tissue lysates (35 µg/lane). CBS (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with CBS Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Mouse Un-conjugated ELISA, WB CBS polyclonal antibody (A01), Lot # NUS1051025QCS1 Western Blot analysis of CBS expression in K-562 . Western Blot detection against Immunogen (86.72 KDa) . 50 μL Log in to see 11 to 12 Days
$227.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC, WB 100 μL Log in to see 2 to 3 Days
$245.00
Details
Human Rabbit Un-conjugated FACS, IF, IHC, WB 100 μL Log in to see 2 to 3 Days
$245.00
Details
Human Rabbit Un-conjugated IF, IHC, WB Western blot analysis of extracts of various cell lines, using CBS antibody. 100 μL Log in to see 16 Days
$366.77
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: CBS Antibody [NBP1-83255] - Staining of human cell line U-251MG shows positivity in nucleoli & vesicles. Immunohistochemistry-Paraffin: CBS Antibody [NBP1-83255] - Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details

Top referenced anti-Cystathionine-beta-Synthase Antibodies

  1. Human Monoclonal CBS Primary Antibody for IHC (p), IP - ABIN560206 : Schicho, Krueger, Zeller, Von Weyhern, Frieling, Kimura, Ishii, De Giorgio, Campi, Schemann: Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon. in Gastroenterology 2006 (PubMed)
    Show all 38 Pubmed References

  2. Human Polyclonal CBS Primary Antibody for ELISA, WB - ABIN560204 : Ali, Whiteman, Low, Moore: Hydrogen sulphide reduces insulin secretion from HIT-T15 cells by a KATP channel-dependent pathway. in The Journal of endocrinology 2007 (PubMed)
    Show all 11 Pubmed References

  3. Cow (Bovine) Polyclonal CBS Primary Antibody for IHC, WB - ABIN2782348 : Urreizti, Asteggiano, Bermudez, Córdoba, Szlago, Szlago, Grosso, de Kremer, Vilarinho, DAlmeida, Martínez-Pardo, Peña-Quintana, Dalmau, Bernal, Briceño, Couce, Rodés, Vilaseca, Balcells, Grinberg: The p.T191M mutation of the CBS gene is highly prevalent among homocystinuric patients from Spain, Portugal and South America. in Journal of human genetics 2006 (PubMed)
    Show all 9 Pubmed References

  4. Human Polyclonal CBS Primary Antibody for ELISA, WB - ABIN560205 : Li, Chen, Muh, Li: Hyperhomocysteinemia associated with decreased renal transsulfuration activity in Dahl S rats. in Hypertension 2006 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal CBS Primary Antibody for WB - ABIN514085 : Qi, Zhou, Xiao, Tao, Gu, Jiang, Xu: Promoter demethylation of cystathionine-?-synthetase gene contributes to inflammatory pain in rats. in Pain 2012 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal CBS Primary Antibody for FACS, IF - ABIN1881141 : Lee, Mariappan, Feliers, Cavaglieri, Sataranatarajan, Abboud, Choudhury, Kasinath: Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells. in The Journal of biological chemistry 2012 (PubMed)
    Show all 2 Pubmed References

  7. Human Monoclonal CBS Primary Antibody for IF, IHC (p) - ABIN514088 : Majtan, Freeman, Smith, Burstyn, Kraus: Purification and characterization of cystathionine ?-synthase bearing a cobalt protoporphyrin. in Archives of biochemistry and biophysics 2011 (PubMed)

  8. Human Polyclonal CBS Primary Antibody for IHC (p), WB - ABIN3042682 : Chen, Wang, Li, Jiang, Lu, Zhou: Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats. in Journal of diabetes research 2016 (PubMed)

  9. Human Polyclonal CBS Primary Antibody for IHC, WB - ABIN6672794 : Niu, Wang, Qian, Wang, Wu, Chen, Yan: Allosteric control of human cystathionine β-synthase activity by a redox active disulfide bond. in The Journal of biological chemistry 2018 (PubMed)

More Antibodies against Cystathionine-beta-Synthase Interaction Partners

Chimpanzee Cystathionine-beta-Synthase (CBS) interaction partners

  1. These genetic evidences suggest that the origin of the 68bp insertion might be dated back to 6-8 million years ago, and that the c.833T>C substitution occurred within the allele carrying the insertion.

Mouse (Murine) Cystathionine-beta-Synthase (CBS) interaction partners

  1. Data suggest that impaired cystathionine beta-synthase-hydrogen sulfide axis may contribute to the pathogenesis of Parkinson's disease, and that modulation of this axis may become a novel therapeutic approach for Parkinson's disease.

  2. results suggested that reduced cystathionine beta-synthase/hydrogen sulfide AMP-activated protein kinase (CBS-H2S-AMPK) cascade activity contributed to microglia-mediated neuroinflammation following stroke.

  3. Results indicate that activation of the cystathionine-beta-synthase (CBS) and its product hydrogen sulfide (CBS/H2S axis promotes colon carcinogenesis.

  4. showed that N-homocysteinylation of collagen in Cbs(-/-) mice impairs its cross-linking

  5. the findings of this study indicate that a deficiency in 3MST does not significantly affect endotoxemia, while a deficiency in CBS or CSE slightly ameliorates the outcome of LPS-induced endotoxemia in vivo.

  6. These data confirm a key role for the H2S-generating enzymes Cbs and Cth in pulmonary vascular development and homeostasis and in lung alveolarization.

  7. genetic deficiency results in reduced Tet1 and Tet2 expression, which leads to hypermethylation of Foxp3, and impairment of Treg cell differentiation and immune homeostasis.

  8. Elevated homocytsteine levels in the CBS-/+ mouse skeletal muscles caused diminished anti-oxidant capacity and contributed to enhanced total protein as well as PGC-1alpha specific nitrotyrosylation after ischemia.

  9. CBS disruption causes embryo retention and developmental delay in the mouse oviduct.

  10. CBS is present in adrenocortical cells and accounts for H2S generation in adrenal glands. CBS is critical for maintenance of mitochondrial function and glucocorticoid production in adrenal cortex.

  11. Elevating endogenous H2S via CBS over-expression in immortalized microglia not only reduced the expression of pro-inflammatory M1 genes, but also enhanced the anti-inflammatory M2 marker IL-10 production.

  12. Cbs protein expression is upregulated in brain cortex following traumatic brain injury.

  13. Brain of mice heterozygous for Cbs displays overexpression of DYR kinase and SAH hydrolase.

  14. These findings set the stage to investigate the role of CBS and the transsulfuration pathway in the generation of GSH in mouse retina.

  15. Hydrogen sulfide in the cortex and hippocampus exhibited dynamic changes after brain injury, in parallel with CBS mRNA and protein expression

  16. Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine beta-synthase: a target for neuronal antioxidant defense.

  17. Cystathionine beta-synthase deficiency causes infertility by impairing decidualization and gene expression networks in uterus implantation sites.

  18. Severe hyperhomocysteinemia promotes bone marrow-derived and resident inflammatory monocyte differentiation and atherosclerosis in LDLr/CBS-deficient mice.

  19. A survey of hemostatic and hemodynamic parameters revealed no detectible differences between control and Tg-I278T Cbs(-/-) mice.

  20. Results show that lack of CBS activity causes loss of fat mass, and that this effect appears to be independent of low serum tCys

Human Cystathionine-beta-Synthase (CBS) interaction partners

  1. Residues 1-40 of cystathionine-beta-synthase (CBS) constitute an intrinsically disordered region in CBS and interact with heme via a cysteine-proline based motif.

  2. CBS expression was increased in all thyroid carcinomas types compared to benign thyroid tissue, but not in thyroid follicular adenomas or oncocytomas.

  3. CBS sequencing resulted in the identification of two novel mutations, a missense change (c.467T>C; p.Leu156Pro) in exon 7 and an in-frame deletion (c.808_810del; p.Glu270del) in exon 10. In addition, a recurrent missense mutation (c.770C>T; p.Thr257Met) in exon 10 of the gene was also identified.

  4. Twenty-one different mutations were detected in nine exons and three introns. Most prevalent were p.Ile278Thr (18.2%), p.Trp323Ter (11.3%), p.Thr191Met (11.3%), and c.828+1G>A (11.3%). Eight novel mutations were found [c.2T>C, c.209+1delG, c.284T>C, c.329A>T, c.444delG, c.864_868delGAG c.989_991delAGG, and c.1223+5G>T]. The expected phenotype according to the genotype (pyridoxine responsiveness) matched in all cases.

  5. Nitration-mediated deficiency of cystathionine beta-synthase activity accelerates the progression of hyperhomocysteinemia.

  6. Abundant expression of CBS, localized in renal tubular epithelial cells, was revealed in human and rat renal tissue, which correlated negatively with the progression of fibrotic disease.

  7. c.797 G>A (p.R266K) cystathionine beta-synthase mutation has a role in causing homocystinuria by affecting protein stability

  8. The current study observed significant differences in the frequency of the CBS 844ins68 allele across populations. There is a significant association between CBS c.844ins68 polymorphism and cleft lip and palate in the Indian population.

  9. Cystathionine beta-synthase and PGRMC1 function as carbon monoxide sensors in health and disease. (Review)

  10. These findings may contribute to highlight that the MTHFR and CBS polymorphisms involvement in sickle cell anemia (SCA)pathophysiology is likely to be far more complex than it was explored to date

  11. Results indicate that activation of the cystathionine-beta-synthase (CBS) and its product hydrogen sulfide (CBS/H2S axis promotes colon carcinogenesis.

  12. Uterine artery hydrogen sulfide production is augmented with endothelium and smooth muscle CBS upregulation, contributing to uterine artery vasodilation in the estrogen-dominant physiological states in the proliferative phase of the menstrual cycle and pregnancy.

  13. Common polymorphisms in MTHFR, methionine synthase and cystathione beta lyase genes have no role in premature acute myocardial infarction in Pakistani population.

  14. Inducible expression of CBS and CSE was found to be associated with a mineralizing phenotype in mesenchymal stem cells transitioning to mineralizing osteoblasts.

  15. SNPs in CBS were not related to relevant changes in homocysteine levels in coronary artery disease patients or controls.

  16. The CBS rs2124459 was associated with a reduced risk of cleft palate in both French and Belgian populations. These results highlight the prominent involvement of the vitamin B6-dependent transsulfuration pathway of homocysteine in orofacial cleft risk and the interest for evaluating vitamin B6 status in further population studies.

  17. There is no ordinary conjunction between human CBS and severe sepsis/septic shock, but CBS genotypes are involved in disease susceptibility.

  18. Oligomeric status of human cystathionine beta-synthase modulates AdoMet binding.

  19. Significant interactions were observed among the methylenetetrahydrofolate reductase (MTHFR; C677T; A1298C) and cystathionine-beta-synthase (CBS; T833C/844ins68, G919A) polymorphisms in the results for homocysteine (Hcy) levels, where heterozygous had higher values.

  20. results indicate that binding of SAM to regulatory and stabilizing sites in CBS may have evolved to display an exquisite thermodynamic and structural specificity towards SAM as well as the ability to transduce the allosteric signal responsible for CBS activation.

Cow (Bovine) Cystathionine-beta-Synthase (CBS) interaction partners

  1. These findings indicate that greater synthesis of phosphatidylcholine and antioxidants contribute to the better performance and immuno-metabolic status in methionine-supplemented cows.

Cystathionine-beta-Synthase (CBS) Antigen Profile

Protein Summary

The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. Multiple alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with CBS

  • cystathionine-beta-synthase L homeolog (cbs.L) antibody
  • cystathionine-beta-synthase (cbs) antibody
  • cystathionine beta-synthase (Cbs) antibody
  • cystathionine-beta-synthase (CBS) antibody
  • cystathionine beta-synthase (CNA06170) antibody
  • cystathionine beta-synthase (Tb11.02.5400) antibody
  • cystathionine beta-synthase CBS (cbs) antibody
  • cystathionine beta-synthase (cbs) antibody
  • cystathionine beta-synthase (cysB) antibody
  • cystathionine beta-synthase (LOC100635325) antibody
  • cystathionine beta synthase (Cbs) antibody
  • cystathionine-beta-synthase S homeolog (cbs.S) antibody
  • cystathionine-beta-synthase b (cbsb) antibody
  • AI047524 antibody
  • AI303044 antibody
  • cb442 antibody
  • cbs antibody
  • DDBDRAFT_0189727 antibody
  • DDBDRAFT_0191292 antibody
  • DDB_0189727 antibody
  • DDB_0191292 antibody
  • GB12529 antibody
  • HIP4 antibody
  • wu:fb37g05 antibody
  • wu:fm61c07 antibody
  • wu:fq06c06 antibody
  • zgc:113704 antibody

Protein level used designations for CBS

cystathionine-beta-synthase , cystathionine beta-synthase , cystathionine beta-synthase CBS , beta-thionase , hemoprotein H-450 , serine sulfhydrase , methylcysteine synthase

GENE ID SPECIES
380308 Xenopus laevis
493533 Xenopus (Silurana) tropicalis
551341 Apis mellifera
736626 Pan troglodytes
3253577 Cryptococcus neoformans var. neoformans JEC21
3665875 Trypanosoma brucei brucei strain 927/4 GUTat10.1
4551426 Mycobacterium ulcerans Agy99
6228672 Mycobacterium marinum M
7006755 Rhodospirillum centenum SW
7705918 Gemmatimonas aurantiaca T-27
7712188 Rhodococcus erythropolis PR4
7746532 Rhodococcus opacus B4
8616308 Dictyostelium discoideum AX4
100136726 Oncorhynchus mykiss
100635325 Amphimedon queenslandica
24250 Rattus norvegicus
12411 Mus musculus
446655 Xenopus laevis
418545 Gallus gallus
875 Homo sapiens
611071 Canis lupus familiaris
514525 Bos taurus
100008766 Oryctolagus cuniculus
266987 Danio rerio
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