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The protein encoded by CBS acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. Additionally we are shipping Cystathionine-beta-Synthase Kits (19) and Cystathionine-beta-Synthase Proteins (17) and many more products for this protein.
Showing 10 out of 138 products:
Human Monoclonal CBS Primary Antibody for IHC (p), IP - ABIN560206
Schicho, Krueger, Zeller, Von Weyhern, Frieling, Kimura, Ishii, De Giorgio, Campi, Schemann: Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon. in Gastroenterology 2006
Show all 38 Pubmed References
Human Polyclonal CBS Primary Antibody for ELISA, WB - ABIN560204
Ali, Whiteman, Low, Moore: Hydrogen sulphide reduces insulin secretion from HIT-T15 cells by a KATP channel-dependent pathway. in The Journal of endocrinology 2007
Show all 11 Pubmed References
Cow (Bovine) Polyclonal CBS Primary Antibody for IHC, WB - ABIN2782348
Urreizti, Asteggiano, Bermudez, Córdoba, Szlago, Szlago, Grosso, de Kremer, Vilarinho, DAlmeida, Martínez-Pardo, Peña-Quintana, Dalmau, Bernal, Briceño, Couce, Rodés, Vilaseca, Balcells, Grinberg: The p.T191M mutation of the CBS gene is highly prevalent among homocystinuric patients from Spain, Portugal and South America. in Journal of human genetics 2006
Show all 9 Pubmed References
Human Polyclonal CBS Primary Antibody for WB - ABIN514085
Qi, Zhou, Xiao, Tao, Gu, Jiang, Xu: Promoter demethylation of cystathionine-?-synthetase gene contributes to inflammatory pain in rats. in Pain 2012
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Human Polyclonal CBS Primary Antibody for ELISA, WB - ABIN560205
Li, Chen, Muh, Li: Hyperhomocysteinemia associated with decreased renal transsulfuration activity in Dahl S rats. in Hypertension 2006
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Human Polyclonal CBS Primary Antibody for FACS, IF - ABIN1881141
Lee, Mariappan, Feliers, Cavaglieri, Sataranatarajan, Abboud, Choudhury, Kasinath: Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells. in The Journal of biological chemistry 2012
Show all 2 Pubmed References
Human Monoclonal CBS Primary Antibody for IF, IHC (p) - ABIN514088
Majtan, Freeman, Smith, Burstyn, Kraus: Purification and characterization of cystathionine ?-synthase bearing a cobalt protoporphyrin. in Archives of biochemistry and biophysics 2011
Data suggest that impaired cystathionine beta-synthase-hydrogen sulfide (show SQRDL Antibodies) axis may contribute to the pathogenesis of Parkinson's disease, and that modulation of this axis may become a novel therapeutic approach for Parkinson's disease.
results suggested that reduced cystathionine beta-synthase/hydrogen sulfide (show SQRDL Antibodies) AMP-activated protein kinase (show PRKAA2 Antibodies) (CBS-H2S-AMPK (show PRKAA1 Antibodies)) cascade activity contributed to microglia-mediated neuroinflammation following stroke.
Results indicate that activation of the cystathionine-beta-synthase (CBS) and its product hydrogen sulfide (show SQRDL Antibodies) (CBS/H2S axis promotes colon carcinogenesis.
showed that N-homocysteinylation of collagen in Cbs(-/-) mice impairs its cross-linking
the findings of this study indicate that a deficiency in 3MST does not significantly affect endotoxemia, while a deficiency in CBS or CSE (show CTH Antibodies) slightly ameliorates the outcome of LPS (show TLR4 Antibodies)-induced endotoxemia in vivo.
These data confirm a key role for the H2S-generating enzymes Cbs and Cth (show CTH Antibodies) in pulmonary vascular development and homeostasis and in lung alveolarization.
genetic deficiency results in reduced Tet1 (show TET1 Antibodies) and Tet2 (show TET2 Antibodies) expression, which leads to hypermethylation of Foxp3 (show FOXP3 Antibodies), and impairment of Treg cell differentiation and immune homeostasis.
Elevated homocytsteine levels in the CBS-/+ mouse skeletal muscles caused diminished anti-oxidant capacity and contributed to enhanced total protein as well as PGC-1alpha specific nitrotyrosylation after ischemia.
CBS disruption causes embryo retention and developmental delay in the mouse oviduct.
CBS is present in adrenocortical cells and accounts for H2S generation in adrenal glands. CBS is critical for maintenance of mitochondrial function and glucocorticoid production in adrenal cortex.
CBS sequencing resulted in the identification of two novel mutations, a missense change (c.467T>C; p.Leu156Pro) in exon 7 and an in-frame deletion (c.808_810del; p.Glu270del) in exon 10. In addition, a recurrent missense mutation (c.770C>T; p.Thr257Met) in exon 10 of the gene was also identified.
Nitration-mediated deficiency of cystathionine beta-synthase activity accelerates the progression of hyperhomocysteinemia.
Abundant expression of CBS, localized in renal tubular epithelial cells, was revealed in human and rat renal tissue, which correlated negatively with the progression of fibrotic disease.
c.797 G>A (p.R266K) cystathionine beta-synthase mutation has a role in causing homocystinuria by affecting protein stability
The current study observed significant differences in the frequency of the CBS 844ins68 allele across populations. There is a significant association between CBS c.844ins68 polymorphism and cleft lip and palate in the Indian population.
Cystathionine beta-synthase and PGRMC1 (show PGRMC1 Antibodies) function as carbon monoxide sensors in health and disease. (Review)
These findings may contribute to highlight that the MTHFR (show MTHFR Antibodies) and CBS polymorphisms involvement in sickle cell anemia (SCA)pathophysiology is likely to be far more complex than it was explored to date
Uterine artery hydrogen sulfide (show SQRDL Antibodies) production is augmented with endothelium and smooth muscle CBS upregulation, contributing to uterine artery vasodilation in the estrogen-dominant physiological states in the proliferative phase of the menstrual cycle and pregnancy.
Common polymorphisms in MTHFR (show MTHFR Antibodies), methionine synthase (show MTR Antibodies) and cystathione beta lyase genes have no role in premature acute myocardial infarction in Pakistani population.
These findings indicate that greater synthesis of phosphatidylcholine (show SGMS1 Antibodies) and antioxidants contribute to the better performance and immuno-metabolic status in methionine-supplemented cows.
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. Multiple alternatively spliced transcript variants have been found for this gene.
, cystathionine beta-synthase
, cystathionine beta-synthase CBS
, hemoprotein H-450
, serine sulfhydrase
, methylcysteine synthase