anti-Cystatin 8 (CST8) Antibodies

Human Cystatin 8 (CST8) interaction partners

1. We show with phylogenetic relations that the CTES genes are clustered into three original groups, a testatin, a Cres, and a CstL1 group

2. studies show that cystatin-related epididymal spermatogenic protein is present in the sperm equatorial segment and becomes accessible to the extracellular environment during fertilization

Mouse (Murine) Cystatin 8 (CST8) interaction partners

1. A 14-kDa CRES isoform resides in the outer dense fibers of the sperm tail.

2. data on the antimicrobial activities of CRES protein suggest that it is a novel and innate antimicrobial protein which protecting the male reproductive tract against invading pathogens

3. CRES may be a regulator of PC4 in sperm-egg interaction and fertilization.

4. loss of CRES has a significant impact on the structure and functions of the testis and epididymis. However, the observed pathologies were prevalent in aged but not in younger adult mice, suggesting that the effects of the loss of CRES are cumulative

5. These results suggest that mice lacking CRES may have altered local levels of cAMP/PKA activity, or that the CRES defect does not directly involve cAMP/PKA but other signaling pathways that regulate protein tyrosine phosphorylation and capacitation.

6. CRES is a new cross-class inhibitor that may regulate PC2 of PC2-like proteases and suggests a role for CRES in the regulation of prohormone and proprotein processing.

7. cystatin-related epididymal spermatogenic protein (CRES) is a competitive inhibitor of prohormone convertase 2 and may regulate proprotein processing within the reproductive and neuroendocrine systems

8. Cres promoter contains the DNA elements necessary for germ cell and pituitary gland-specific expression but lacks critical sequences necessary for expression in the epididymis and ovary.

9. studies suggest that Cres mRNA and protein are low at peak gonadotrope secretory activity, possibly as a means to allow proprotein processing events to occur that are integral to gonadotrope function

10. The Cres gene displays a specific age-dependent expression pattern in mouse testis and epididymis on both the mRNA and protein level.