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May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation..
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Crisp2 genetic defects in sperm from humans and mice result in male infertility.
expression and localization of SHTAP (show NSUN4 Proteins) in testis and sperm raise the possibility that the SHTAP (show NSUN4 Proteins)-CRISP2 complex has a potential role in sperm formation and/or function.
Tpx-1 Crisp domain on its own can regulate ion channel activity and provide compelling evidence for a role for Tpx-1 in the regulation of Ca(2 (show CA2 Proteins)+) fluxes observed during sperm capacitation.
Evidence for a functional role of CRISP2 in fertilization.
These data raise the possibility that CRISP2 is a MAP3K11 (show MAP3K11 Proteins)-modifying protein or, alternatively, that MAP3K11 (show MAP3K11 Proteins) acts to phosphorylate CRISP2 during acrosome development.
low expression of CRISP2 protein rather than its mRNA was observed in the ejaculated spermatozoa from asthenoteratozoospermic patients as compared with normozoospermic males
Results identified CRISP2 as a potential binding protein of PSP94 (show MSMB Proteins) from human sperm.
Preliminary insight into the mechanism leading to the reduced CRISP2 expression in asthenozoospermia, offering a potential therapeutic target for treating male infertility or for male contraception.
Study shows the re-association of sperm acrosomal CRISP2 at the EqS during the acrosome reaction. Data showed that F-actin is not involved in the relocalization of CRISP2. Found that basic,but not acidic, conditions can solubilize CRISP2 from sperm cells.
CRISP2 rescues the phenotype of yeast mutants lacking Pry function and purified CRISP2 binds cholesterol in vitro, indicating that lipid binding is a conserved function of the CAP superfamily proteins.
The down-regulation of CRISP2 mRNA and protein expressions in the sperm of asthenospermia patients may be closely related with decreased sperm motility.
Additional transcription changes likely associated with Th2-like eosinophilic inflammation were prominent and included decreased CRISP2&3.
TPX1 (show PRDX2 Proteins) is a component of the sperm acrosome that remains associated with sperm after capacitation and acrosome reaction , and is relevant for sperm-oocyte interaction.
The protein level and localization of TPX1 (show PRDX2 Proteins) were altered in patients with spermatogenic arrest and in infertile men with oligoasthenoteratospermia syndrome.
CRISP2 mRNA levels are associated with male fertility.
May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation.
cysteine-rich secretory protein 2
, cysteine rich secretory protein
, cysteine-rich secretory protein 3
, cystein-rich secretory protein 2
, cysteine-rich secretory protein-2
, testis specific gene 1
, testis-specific protein TPX-1
, cysteine-rich secretory protein 2-like
, testis specific protein 1
, cancer/testis antigen 36
, glyceraldehyde-3-phosphate dehydrogenase-like 5
, testis specific protein 1 (probe H4-1 p3-1)
, cysteine-rich secretory protein-3
, cysteine-rich secretory protein 1
, autoantigen 1