anti-Cytochrome P450, Family 2, Subfamily C, Polypeptide 8 (CYP2C8) Antibodies

CYP2C8 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping CYP2C8 Proteins (3) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CYP2C8 1558 P10632
CYP2C8    
CYP2C8    
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Top anti-CYP2C8 Antibodies at antibodies-online.com

Showing 10 out of 56 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human testis, using Cytochrome P450 2C8 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 16 Days
$181.73
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 11 to 14 Days
$610.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB   200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-CYP2C8 Antibody (N-term) (ABIN392529) in T47D cell line lysates (35 µg/lane). CYP2C8(arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: Cytochrome P450 2C8 Antibody [NBP1-88055] - Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes. Immunohistochemistry-Paraffin: Cytochrome P450 2C8 Antibody  - Staining of human liver shows high expression. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: Cytochrome P450 2C8 Antibody [NBP1-88054] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp.Lane 4: Human plasma (IgG/HSA depleted).Lane 5: Human liver tissue.Lane 6: Human tonsil tissue Immunohistochemistry-Paraffin: Cytochrome P450 2C8 Antibody [NBP1-88054] - Staining of human liver shows strong cytoplasmic positivity in hepatocytes. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated ELISA, IHC, WB ABIN6274646 at 1/100 staining Human cervical cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts from rat brain cells, using Cytochrome P450 2C8 Antibody.The lane on the left is treated with the antigen-specific peptide. 100 μL Log in to see 11 to 12 Days
$390.77
Details

Top referenced anti-CYP2C8 Antibodies

  1. Human Polyclonal CYP2C8 Primary Antibody for ELISA, WB - ABIN4302095 : Leskelä, Jara, Leandro-García, Martínez, García-Donas, Hernando, Hurtado, Vicario, Montero-Conde, Landa, López-Jiménez, Cascón, Milne, Robledo, Rodríguez-Antona: Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neurotoxicity. in The pharmacogenomics journal 2011 (PubMed)

More Antibodies against CYP2C8 Interaction Partners

Human Cytochrome P450, Family 2, Subfamily C, Polypeptide 8 (CYP2C8) interaction partners

  1. In the villous trophoblast, CYP2C8 was the most abundant protein. Its expression is higher than the CYP2C9 and CYP2J2 in the cytotrophoblast in the embryonic stage of development and remains higher in syncytiotrophoblast of term placenta.

  2. The present study confirms the variable distribution of CYP2C8 (*2 and *3) and CYP2C9 (*2 and *3) allelic polymorphisms among South Indian diabetic populations.

  3. We found that SNPs rs7909236 and rs1934953 of the CYP2C8 gene were significantly associated with increased risk of essential hypertension.

  4. Clopidogrel increases the exposure to pioglitazone by inhibiting its CYP2C8-mediated biotransformation.

  5. Using an integrated pathway-based approach, we identified polymorphisms in ABCC6, ABCB1 and CYP2C8 associated with overall survival. These associations were replicated in a large independent cohort, highlighting the importance of pharmacokinetic genes as prognostic markers in Ewing sarcoma

  6. review summarizes glucuronides as CYP2C8 ligands and the active-site structural features of CYP2C8 that allow potential binding to glucuronides

  7. Preliminary results demonstrate SNPs in CYP2C8 represent potential genetic markers of coronary heart disease susceptibility.

  8. Inhibition of CYP2C8 activity adds to the protective effects of omega-3 LCPUFA on pathological retinal neovascularization and choroidal neovascularization.

  9. CYP2C8*3 carriers had an increased risk of peripheral neuropathy

  10. CYP2C8 Variants are associated with Ischemic Stroke.

  11. This review focuses on recent findings of in vitro studies on drug metabolizing activity of 3 highly polymorphic CYP2C members: CYP2C8, CYP2C9, and CYP2C19.

  12. CYP2C8*3 is a gain-of-function polymorphism for imatinib N-demethylation, which appears to be mainly mediated by CYP2C8 and not CYP3A4 in vitro in human liver microsomes

  13. CYP2C8 genetic polymorphisms may influence outcome of taxane therapy in Roma and Hungarian populations.

  14. CYP2C8-derived epoxyeicosatrienoic acids prevented TNF-alpha-induced HUVECs apoptosis via inhibition of oxidative stress associated with the Nrf2 signaling.

  15. Interaction among CYP2C8, EPHX2, and CYP4A11 Gene Variants Significantly Increases the Risk for Ischemic Stroke.

  16. These comprehensive findings could inform for further genotype-phenotype studies on interindividual differences in CYP2C8-mediated drug metabolism

  17. Significant gene-sex interaction for CYP2C8*3 with twofold increase in the relative risk of essential hypertension and a similar tendency for CYP2J2*7 associated with coronary artery disease without myocardial infarction in Bulgarian males.

  18. We did not observe any association of CYP2C8*2, CYP2C8*3, CYP2C9*2 and CYP2C9*3 with myocardial infarction

  19. CYP2C8 polymorphisms affected neither R- nor S-ibuprofen

  20. the CYP2C8*3 allele has no major impact on paclitaxel metabolism in vitro or of paclitaxel-induced neuropathy

CYP2C8 Antigen Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene.

Gene names and symbols associated with CYP2C8

  • cytochrome P450 family 2 subfamily C member 8 (CYP2C8) antibody
  • Cytochrome P450 2C8 (CTN_0597) antibody
  • cytochrome P450, family 2, subfamily C, polypeptide 8 (CYP2C8) antibody
  • cytochrome P450 family 2 subfamily C member 8 S homeolog (cyp2c8.1.S) antibody
  • cytochrome P450 family 2 subfamily C member 8 (cyp2c8.1) antibody
  • cpc8 antibody
  • cyp2c8 antibody
  • CYP2C74 antibody
  • cypiic8 antibody
  • mp-12/mp-20 antibody

Protein level used designations for CYP2C8

P450 form 1 , cytochrome P450 2C8 , cytochrome P450 IIC2 , cytochrome P450 MP-12 , cytochrome P450 MP-20 , cytochrome P450 form 1 , cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8 , flavoprotein-linked monooxygenase , microsomal monooxygenase , s-mephenytoin 4-hydroxylase , xenobiotic monooxygenase , Cytochrome P450 2C8 , cytochrome P450 CYP2C74 , cytochrome P450, family 2, subfamily C, polypeptide 8

GENE ID SPECIES
1558 Homo sapiens
7378980 Thermotoga neapolitana DSM 4359
678683 Macaca mulatta
379297 Xenopus laevis
450909 Pan troglodytes
100127852 Xenopus (Silurana) tropicalis
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