anti-Cytoglobin (CYGB) Antibodies

CYGB encodes a globin protein found in vertebrate cells. Additionally we are shipping Cytoglobin Proteins (15) and Cytoglobin Kits (14) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CYGB 114886 Q9CX80
CYGB 114757 Q8WWM9
CYGB 170520 Q921A4
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Top anti-Cytoglobin Antibodies at

Showing 10 out of 77 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of Cytoglobin using anti-Cytoglobin antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: rat small intestine tissue lysates,   Lane 2: mouse small intestine tissue lysates,  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-Cytoglobin antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for Cytoglobin at approximately 21KD. The expected band size for Cytoglobin is at 21KD. IHC analysis of Cytoglobin using anti- Cytoglobin antibody . Cytoglobin was detected in paraffin-embedded section of mouse intestine tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti- Cytoglobin Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. 100 μg 4 to 6 Days
Human Rabbit Un-conjugated WB Western blot analysis of Cytoglobin expression in HeLa (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL 13 to 14 Days
Human Rabbit Un-conjugated EIA, WB Western blot analysis of Cytoglobin (N-term) in HepG2 cell line lysates (35ug/lane). This demonstrates the CYGB antibody detected the CYGB protein (arrow). 0.4 mL 6 to 8 Days
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat colon tissue labeled with Anti-Cygb Polyclonal Antibody (ABIN670566), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-Cygb Polyclonal Antibody (ABIN670566), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL 3 to 7 Days
Human Mouse Un-conjugated IF, IHC (p), ELISA, WB Western Blot analysis of CYGB expression in transfected 293T cell line by CYGB monoclonal antibody (M02), clone 1A1.Lane 1: CYGB transfected lysate(21 KDa).Lane 2: Non-transfected lysate. Immunoperoxidase of monoclonal antibody to CYGB on formalin-fixed paraffin-embedded human heart. [antibody concentration 3 ug/ml] 100 μg 11 to 12 Days
Rat Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Lane1: Rat Serum; Lane2: Rat Heart Tissue; Lane3: Rat Kidney Tissue. Figure. Western Blot; Sample: Recombinant CYGB, Rat. 100 μg 13 to 16 Days
Human Mouse Un-conjugated IF, ELISA, WB 100 μg 11 to 14 Days
Human Rabbit Un-conjugated ICC, IF, WB 100 μL 11 to 14 Days
Human Rabbit Un-conjugated ELISA, WB   100 μL Available
Human Rabbit Un-conjugated WB 100 μg 4 to 6 Days

Top referenced anti-Cytoglobin Antibodies

  1. Human Monoclonal CYGB Primary Antibody for IF, IHC (p) - ABIN566715 : Li, Lee, Pouranfar, Brittian, Clair, Row, Wang, Gozal: Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain. in Brain research 2006 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal CYGB Primary Antibody for ICC, IF - ABIN4302128 : Svenson, Case, Cole, Hwang, Kabir, Lazarus, Lim Soo, Ng, Peters, Shum, Sweryda-Krawiec, Tripathi, van der Poll, Eliasof: Tumor Selective Silencing Using an RNAi-Conjugated Polymeric Nanopharmaceutical. in Molecular pharmaceutics 2016 (PubMed)

  3. Human Polyclonal CYGB Primary Antibody for IF (p), IHC (p) - ABIN670566 : Xu, Huang, Xie, Lin, Guo, Zhuang, Lin, Zhou, Li, Huang, Wei, Man, Zhang: The expression of cytoglobin as a prognostic factor in gliomas: a retrospective analysis of 88 patients. in BMC cancer 2013 (PubMed)

More Antibodies against Cytoglobin Interaction Partners

Zebrafish Cytoglobin (CYGB) interaction partners

  1. The results uncover unexpected properties of zebrafish cytoglobin 1 and reveal the pivotal role of cytoglobin 1 in the transition of heme cytoglobin 1 from six-coordinate to five-coordinate oxygen carriers and nitrite reductases.

Mouse (Murine) Cytoglobin (CYGB) interaction partners

  1. Cygb has a critical role in the regulation of vascular tone and disease. We suggest that modulation of the expression and NOD activity of Cygb represents a strategy for the treatment of cardiovascular disease

  2. Expression of all fibrosis-related markers following bile duct ligation was significantly increased in Cygb(-/-) mice compared with wild-type mice. Cygb deficiency enhances hepatocyte damage and inflammation.

  3. we identified CYGB as an important regulator of osteosarcoma (OS) extravasation and highlighted the importance of the LEF1-CYGB regulatory axis in OS metastasis to the lungs.

  4. This study demonstrated the role of CYGB in fibroblast cell motility and proliferation. CYGB could be a promising candidate for further studies as a potential target for diseases related to cell migration such as cancer and chronic wound treatment.

  5. Thus, the absence of Cygb in pericytes provokes organ abnormalities, possibly via derangement of the nitric oxide and antioxidant defence system and through accelerated cellular senescence.

  6. Findings provide evidence for the loss of globin-linked neuroprotection to be linked to Alzheimer's disease angiopathogenesis, while raising the possibility of REST/ NRSF being an upstream regulator.

  7. Cygb, expressed in hepatic stellate cells during liver fibrosis, plays role in cancer development with nonalcoholic steatohepatitis.

  8. Studied hepatic stellate cell cytoglobin involvement in acetaminophen induced hepatotoxicity through the regulation of CYP2E1.

  9. cytoglobin serves an important role in muscle repair and regeneration

  10. Cygb deficiency induces susceptibility to cancer development in the liver and lungs of mice exposed to N,N-diethylnitrosamine

  11. The anatomical data indicate a role in NO signalling for cytoglobin and involvement in sleep-wake cycling for cytoglobin and neuroglobin

  12. The nuclear localization of cytoglobin opens new perspectives for possible function(s) of globin-folded proteins as transcriptional regulators.

  13. differential expression of cytoglobin argues against a general respiratory function of this molecule, but rather indicates a connective tissue-specific function

  14. cytoglobin is significantly upregulated upon hypoxia and this is dependent on the tissue and severity of hypoxia

  15. In the neuronal retina, cytoglobin is expressed in a subset of neurons of the ganglion cell and inner nuclear layers. Cytoglobin is also present in the inner plexiform layer, but absent from the pigment cells.

  16. Cygb is an oxygen-responsive tissue hemoglobin expressed in distinct regions of thenormoxic and hypoxic brain and may play a key role in the response of the brain to ahypoxic insult.

  17. Cygb expression is correlated with reactive oxygen species scavenging.

  18. Data suggest that cytoglobin in neuronal cells might be specifically induced under oxidative stress to protect them from death.

  19. cytoglobin contributes to cell-mediated NO dioxygenation and represents an important NO sink in the vascular wall.

  20. Data suggest that the regulation of cytoglobin transcription by calcineurin-dependent transcription factors suggests that cytoglobin may have a functional role in calcium-dependent events accompanying cardiac remodeling.

Human Cytoglobin (CYGB) interaction partners

  1. Nitric oxide generation by cytoglobin nitrite reductase activity is modulated by the oxidation state of surface-exposed cysteines C38 and C83.Cysteine oxidation has no discernible effect on the rate of nitric oxide dioxygenase activity but does influence the rate of penta-to hexa-heme iron coordination following nitrate dissociation.

  2. CYGB is a potential tumor suppressor in breast cancer that is epigenetically suppressed. The results for the first time suggest that CYGB suppresses breast cancer through inhibiting glucose metabolism.

  3. The results obtained in this study (1) show that plasma-produced reactive oxygen and nitrogen species can extensively oxidize proteins and (2) that the oxidation status of two redox-active cysteines lead to different conformations of CYGB.

  4. Endothelial cells facilitate the ability of smooth muscle cells to metabolize nitric oxide through upregulation of cytoglobin.

  5. FGF2 initiates CYGB transcription via the JNK pathway.

  6. the study reveals a novel mechanism for the regulated expression of Cygb and also assigns a new role to Cygb in cell cycle control.

  7. Data suggest that cytochrome b5 (CYB5) and cytochrome b5 reductase 3 (CYB5R3) can reduce human cytoglobin (CYGB) and zebrafish cytoglobins at rates up to 250-fold higher than those reported for the known physiological substrates, hemoglobin and myoglobin; the three proteins (CYB5+CYB5R3+CYGB) appear to constitute a metabolon involved in generation of nitric oxide.

  8. DeltaNp63-CYGB axis is also present in lung and breast cancer cell lines, indicating that CYGB-mediated ROS-scavenging activity may also have a role in epithelial tumours

  9. Propose a bipartite lipid binding model that rationalizes the modes of interactions of cytoglobin with phospholipids, the effects on structural re-arrangements and the peroxidase activity of the hemoprotein.

  10. This review provides an overview of the proposed role of cytoglobin and explores its potential functional role as a biomarker for cancer and other diseases

  11. Cygb, expressed in hepatic stellate cells during liver fibrosis, plays role in cancer development with nonalcoholic steatohepatitis.

  12. Cygb stabilizes p53 by inhibiting its ubiquitination and elicit cell cycle arrest in DNA damaged cells.

  13. The cysteine redox state of the monomer controls histidine dissociation rate constants and hence extrinsic ligand binding in human cytoglobin.

  14. The monomeric cytoglobin protein with an internal disulfide bond between the two cysteine residues Cys38 and Cys83, interacts with lipids to induce a change in haem co-ordination.

  15. Protein multimerization may be a mechanism that triggers physiological functions of human cytoglobin.

  16. Our data provides evidence that cytoglobin regulates the ovarian cancer cell proliferation and invasion.

  17. This review outlines the current understanding of Cygb's involvement in tumor hypoxia and discusses its role in tumorigenesis.

  18. Molecular dynamics studies of four cytoglobinCO models indicated that the distal E7 residue was a crucial influence on the dynamics of cytoglobinCO in terms of loop fluctuations, cavity rearrangement, and slight heme motion.

  19. Reduction of the internal disulfide bond between Cys 38 and 83 switches the ligand migration pathway in cytoglobin.

  20. Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver, so it thus a useful marker to distinguish these cells.

Cytoglobin (CYGB) Antigen Profile

Protein Summary

This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation.

Gene names and symbols associated with anti-Cytoglobin (CYGB) Antibodies

  • cytoglobin 1 (cygb1) antibody
  • cytoglobin (cygb) antibody
  • cytoglobin (CYGB) antibody
  • cytoglobin-1 (cygb1) antibody
  • cytoglobin L homeolog (cygb.L) antibody
  • cytoglobin (Cygb) antibody
  • 3110001K20Rik antibody
  • CYGB antibody
  • cygb-1 antibody
  • HGB antibody
  • MGC84306 antibody
  • MGC89562 antibody
  • Staap antibody
  • Stap antibody
  • wu:fb77d07 antibody
  • wu:fb93a03 antibody
  • zgc:109806 antibody

Protein level used designations for anti-Cytoglobin (CYGB) Antibodies

cyt , cytoglobin-1 , cytoglobin , histoglobin , stellate cell activation associated protein , stellate cell activation-associated protein , HGb

246090 Danio rerio
448640 Xenopus (Silurana) tropicalis
707130 Macaca mulatta
739843 Pan troglodytes
100049376 Oryzias latipes
100136084 Oncorhynchus mykiss
100307038 Ovis aries
447575 Xenopus laevis
100224652 Taeniopygia guttata
100357278 Oryctolagus cuniculus
114886 Mus musculus
114757 Homo sapiens
427802 Gallus gallus
609341 Canis lupus familiaris
510299 Bos taurus
170520 Rattus norvegicus
100058726 Equus caballus
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