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CYGB encodes a globin protein found in vertebrate cells. Additionally we are shipping Cytoglobin Kits (19) and Cytoglobin Proteins (15) and many more products for this protein.
Showing 10 out of 73 products:
Human Monoclonal CYGB Primary Antibody for IF, IHC (p) - ABIN566715
Li, Lee, Pouranfar, Brittian, Clair, Row, Wang, Gozal: Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain. in Brain research 2006
Show all 5 Pubmed References
Human Polyclonal CYGB Primary Antibody for IF (p), IHC (p) - ABIN670566
Xu, Huang, Xie, Lin, Guo, Zhuang, Lin, Zhou, Li, Huang, Wei, Man, Zhang: The expression of cytoglobin as a prognostic factor in gliomas: a retrospective analysis of 88 patients. in BMC cancer 2013
Human Polyclonal CYGB Primary Antibody for ICC, IF - ABIN4302128
Svenson, Case, Cole, Hwang, Kabir, Lazarus, Lim Soo, Ng, Peters, Shum, Sweryda-Krawiec, Tripathi, van der Poll, Eliasof: Tumor Selective Silencing Using an RNAi-Conjugated Polymeric Nanopharmaceutical. in Molecular pharmaceutics 2016
Human Monoclonal CYGB Primary Antibody for ELISA, IF - ABIN394736
Mogal, Watson, Ozsolak, Salavaggione, Humphrey: Gene expression profiles and differential cytoglobin expression in atrophy and adenocarcinoma of the prostate. in The Prostate 2012
The results uncover unexpected properties of zebrafish cytoglobin 1 and reveal the pivotal role of cytoglobin 1 in the transition of heme cytoglobin 1 from six-coordinate to five-coordinate oxygen carriers and nitrite reductases.
we identified CYGB as an important regulator of osteosarcoma (OS) extravasation and highlighted the importance of the LEF1 (show LEF1 Antibodies)-CYGB regulatory axis in OS metastasis to the lungs.
This study demonstrated the role of CYGB in fibroblast cell motility and proliferation. CYGB could be a promising candidate for further studies as a potential target for diseases related to cell migration such as cancer and chronic wound treatment.
Thus, the absence of Cygb in pericytes provokes organ abnormalities, possibly via derangement of the nitric oxide and antioxidant defence system and through accelerated cellular senescence.
Findings provide evidence for the loss of globin-linked neuroprotection to be linked to Alzheimer's disease angiopathogenesis, while raising the possibility of REST/ NRSF (show REST Antibodies) being an upstream regulator.
Cygb, expressed in hepatic stellate cells during liver fibrosis, plays role in cancer development with nonalcoholic steatohepatitis.
Studied hepatic stellate cell cytoglobin involvement in acetaminophen induced hepatotoxicity through the regulation of CYP2E1 (show CYP2E1 Antibodies).
cytoglobin serves an important role in muscle repair and regeneration
Cygb deficiency induces susceptibility to cancer development in the liver and lungs of mice exposed to N,N-diethylnitrosamine
The anatomical data indicate a role in NO signalling for cytoglobin and involvement in sleep-wake cycling for cytoglobin and neuroglobin (show NGB Antibodies)
The nuclear localization of cytoglobin opens new perspectives for possible function(s) of globin-folded proteins as transcriptional regulators.
the study reveals a novel mechanism for the regulated expression of Cygb and also assigns a new role to Cygb in cell cycle control.
Data suggest that cytochrome b5 (CYB5 (show CYB5A Antibodies)) and cytochrome b5 reductase 3 (CYB5R3 (show CYB5R3 Antibodies)) can reduce human cytoglobin (CYGB) and zebrafish cytoglobins at rates up to 250-fold higher than those reported for the known physiological substrates, hemoglobin (show HBB Antibodies) and myoglobin (show MB Antibodies); the three proteins (CYB5 (show CYB5A Antibodies)+CYB5R3 (show CYB5R3 Antibodies)+CYGB) appear to constitute a metabolon involved in generation of nitric oxide.
DeltaNp63-CYGB axis is also present in lung and breast cancer cell lines, indicating that CYGB-mediated ROS (show ROS1 Antibodies)-scavenging activity may also have a role in epithelial tumours
Propose a bipartite lipid binding model that rationalizes the modes of interactions of cytoglobin with phospholipids, the effects on structural re-arrangements and the peroxidase activity of the hemoprotein.
This review provides an overview of the proposed role of cytoglobin and explores its potential functional role as a biomarker for cancer and other diseases
Cygb stabilizes p53 (show TP53 Antibodies) by inhibiting its ubiquitination and elicit cell cycle arrest in DNA damaged cells.
The cysteine redox state of the monomer controls histidine dissociation rate constants and hence extrinsic ligand binding in human cytoglobin.
The monomeric cytoglobin protein with an internal disulfide bond between the two cysteine residues Cys38 and Cys83, interacts with lipids to induce a change in haem co-ordination.
Protein multimerization may be a mechanism that triggers physiological functions of human cytoglobin.
This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation.
, stellate cell activation associated protein
, stellate cell activation-associated protein