anti-Cytoglobin (CYGB) Antibodies

CYGB encodes a globin protein found in vertebrate cells. Additionally we are shipping Cytoglobin Kits (19) and Cytoglobin Proteins (15) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CYGB 114886 Q9CX80
CYGB 114757 Q8WWM9
CYGB 170520 Q921A4
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Top anti-Cytoglobin Antibodies at antibodies-online.com

Showing 10 out of 73 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of Cytoglobin using anti-Cytoglobin antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: rat small intestine tissue lysates,   Lane 2: mouse small intestine tissue lysates,  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-Cytoglobin antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for Cytoglobin at approximately 21KD. The expected band size for Cytoglobin is at 21KD. IHC analysis of Cytoglobin using anti- Cytoglobin antibody . Cytoglobin was detected in paraffin-embedded section of mouse intestine tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti- Cytoglobin Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Mouse Un-conjugated ELISA, IF, IHC, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (46.64 KDa) . Dilution: 1:500~1000 100 μg Log in to see 8 to 11 Days
$461.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB Western Blot: Cytoglobin Antibody [NBP2-16084] - Sample (30 ug of whole cell lysate) A: IMR32 12% SDS PAGE gel, diluted at 1:2000. Immunocytochemistry/Immunofluorescence: Cytoglobin Antibody [NBP2-16084] - Immunofluorescence analysis of methanol-fixed A431, using antibody at 1:500 dilution. 0.1 mL Log in to see 8 to 11 Days
$514.63
Details
Human Rabbit Un-conjugated WB Western blot analysis of Cytoglobin expression in HeLa (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of Cytoglobin (N-term) in HepG2 cell line lysates (35ug/lane). This demonstrates the CYGB antibody detected the CYGB protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: Cytoglobin Antibody [NBP1-89701] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY408741) Immunohistochemistry-Paraffin: Cytoglobin Antibody [NBP1-89701] - Staining of human duodenum shows moderate slightly granular cytoplasmic positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat colon tissue labeled with Anti-Cygb Polyclonal Antibody (ABIN670566), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-Cygb Polyclonal Antibody (ABIN670566), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$318.45
Details
Human Mouse Un-conjugated IF, IHC (p), ELISA, WB Western Blot analysis of CYGB expression in transfected 293T cell line by CYGB monoclonal antibody (M02), clone 1A1.<br><br>Lane 1: CYGB transfected lysate(21 KDa).<br>Lane 2: Non-transfected lysate.<br> Immunoperoxidase of monoclonal antibody to CYGB on formalin-fixed paraffin-embedded human heart. [antibody concentration 3 ug/ml] 100 μg Log in to see 11 to 12 Days
$440.00
Details
Rat Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Lane1: Rat Serum; Lane2: Rat Heart Tissue; Lane3: Rat Kidney Tissue. Figure. Western Blot; Sample: Recombinant CYGB, Rat. 100 μg Log in to see 13 to 16 Days
$380.00
Details
Human Mouse Un-conjugated IF, ELISA, WB 100 μg Log in to see 7 to 9 Days
$537.17
Details

Top referenced anti-Cytoglobin Antibodies

  1. Human Monoclonal CYGB Primary Antibody for IF, IHC (p) - ABIN566715 : Li, Lee, Pouranfar, Brittian, Clair, Row, Wang, Gozal: Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain. in Brain research 2006 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal CYGB Primary Antibody for IF (p), IHC (p) - ABIN670566 : Xu, Huang, Xie, Lin, Guo, Zhuang, Lin, Zhou, Li, Huang, Wei, Man, Zhang: The expression of cytoglobin as a prognostic factor in gliomas: a retrospective analysis of 88 patients. in BMC cancer 2013 (PubMed)

  3. Human Polyclonal CYGB Primary Antibody for ICC, IF - ABIN4302128 : Svenson, Case, Cole, Hwang, Kabir, Lazarus, Lim Soo, Ng, Peters, Shum, Sweryda-Krawiec, Tripathi, van der Poll, Eliasof: Tumor Selective Silencing Using an RNAi-Conjugated Polymeric Nanopharmaceutical. in Molecular pharmaceutics 2016 (PubMed)

  4. Human Monoclonal CYGB Primary Antibody for ELISA, IF - ABIN394736 : Mogal, Watson, Ozsolak, Salavaggione, Humphrey: Gene expression profiles and differential cytoglobin expression in atrophy and adenocarcinoma of the prostate. in The Prostate 2012 (PubMed)

More Antibodies against Cytoglobin Interaction Partners

Zebrafish Cytoglobin (CYGB) interaction partners

  1. The results uncover unexpected properties of zebrafish cytoglobin 1 and reveal the pivotal role of cytoglobin 1 in the transition of heme cytoglobin 1 from six-coordinate to five-coordinate oxygen carriers and nitrite reductases.

Mouse (Murine) Cytoglobin (CYGB) interaction partners

  1. we identified CYGB as an important regulator of osteosarcoma (OS) extravasation and highlighted the importance of the LEF1 (show LEF1 Antibodies)-CYGB regulatory axis in OS metastasis to the lungs.

  2. This study demonstrated the role of CYGB in fibroblast cell motility and proliferation. CYGB could be a promising candidate for further studies as a potential target for diseases related to cell migration such as cancer and chronic wound treatment.

  3. Thus, the absence of Cygb in pericytes provokes organ abnormalities, possibly via derangement of the nitric oxide and antioxidant defence system and through accelerated cellular senescence.

  4. Findings provide evidence for the loss of globin-linked neuroprotection to be linked to Alzheimer's disease angiopathogenesis, while raising the possibility of REST/ NRSF (show REST Antibodies) being an upstream regulator.

  5. Cygb, expressed in hepatic stellate cells during liver fibrosis, plays role in cancer development with nonalcoholic steatohepatitis.

  6. Studied hepatic stellate cell cytoglobin involvement in acetaminophen induced hepatotoxicity through the regulation of CYP2E1 (show CYP2E1 Antibodies).

  7. cytoglobin serves an important role in muscle repair and regeneration

  8. Cygb deficiency induces susceptibility to cancer development in the liver and lungs of mice exposed to N,N-diethylnitrosamine

  9. The anatomical data indicate a role in NO signalling for cytoglobin and involvement in sleep-wake cycling for cytoglobin and neuroglobin (show NGB Antibodies)

  10. The nuclear localization of cytoglobin opens new perspectives for possible function(s) of globin-folded proteins as transcriptional regulators.

Human Cytoglobin (CYGB) interaction partners

  1. the study reveals a novel mechanism for the regulated expression of Cygb and also assigns a new role to Cygb in cell cycle control.

  2. Data suggest that cytochrome b5 (CYB5 (show CYB5A Antibodies)) and cytochrome b5 reductase 3 (CYB5R3 (show CYB5R3 Antibodies)) can reduce human cytoglobin (CYGB) and zebrafish cytoglobins at rates up to 250-fold higher than those reported for the known physiological substrates, hemoglobin (show HBB Antibodies) and myoglobin (show MB Antibodies); the three proteins (CYB5 (show CYB5A Antibodies)+CYB5R3 (show CYB5R3 Antibodies)+CYGB) appear to constitute a metabolon involved in generation of nitric oxide.

  3. DeltaNp63-CYGB axis is also present in lung and breast cancer cell lines, indicating that CYGB-mediated ROS (show ROS1 Antibodies)-scavenging activity may also have a role in epithelial tumours

  4. Propose a bipartite lipid binding model that rationalizes the modes of interactions of cytoglobin with phospholipids, the effects on structural re-arrangements and the peroxidase activity of the hemoprotein.

  5. This review provides an overview of the proposed role of cytoglobin and explores its potential functional role as a biomarker for cancer and other diseases

  6. Cygb, expressed in hepatic stellate cells during liver fibrosis, plays role in cancer development with nonalcoholic steatohepatitis.

  7. Cygb stabilizes p53 (show TP53 Antibodies) by inhibiting its ubiquitination and elicit cell cycle arrest in DNA damaged cells.

  8. The cysteine redox state of the monomer controls histidine dissociation rate constants and hence extrinsic ligand binding in human cytoglobin.

  9. The monomeric cytoglobin protein with an internal disulfide bond between the two cysteine residues Cys38 and Cys83, interacts with lipids to induce a change in haem co-ordination.

  10. Protein multimerization may be a mechanism that triggers physiological functions of human cytoglobin.

Cytoglobin (CYGB) Antigen Profile

Protein Summary

This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation.

Gene names and symbols associated with anti-Cytoglobin (CYGB) Antibodies

  • cytoglobin 1 (cygb1) antibody
  • cytoglobin (cygb) antibody
  • cytoglobin (CYGB) antibody
  • cytoglobin-1 (cygb1) antibody
  • cytoglobin L homeolog (cygb.L) antibody
  • cytoglobin (Cygb) antibody
  • 3110001K20Rik antibody
  • CYGB antibody
  • cygb-1 antibody
  • HGB antibody
  • MGC84306 antibody
  • MGC89562 antibody
  • Staap antibody
  • Stap antibody
  • wu:fb77d07 antibody
  • wu:fb93a03 antibody
  • zgc:109806 antibody

Protein level used designations for anti-Cytoglobin (CYGB) Antibodies

cyt , cytoglobin-1 , cytoglobin , histoglobin , stellate cell activation associated protein , stellate cell activation-associated protein , HGb

GENE ID SPECIES
246090 Danio rerio
448640 Xenopus (Silurana) tropicalis
707130 Macaca mulatta
739843 Pan troglodytes
100049376 Oryzias latipes
100136084 Oncorhynchus mykiss
100307038 Ovis aries
447575 Xenopus laevis
100224652 Taeniopygia guttata
100357278 Oryctolagus cuniculus
114886 Mus musculus
114757 Homo sapiens
427802 Gallus gallus
609341 Canis lupus familiaris
510299 Bos taurus
170520 Rattus norvegicus
100058726 Equus caballus
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