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The protein encoded by DDO is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Additionally we are shipping D-Aspartate Oxidase Antibodies (62) and D-Aspartate Oxidase Proteins (15) and many more products for this protein.
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Human DDO ELISA Kit for Sandwich ELISA - ABIN857884
Willoughby, Leutholtz et al.: D-aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the ... in Nutrition research (New York, N.Y.) 2013
In this framework, an epiallele is defined as a specific combination of methylated CpG within Ddo locus and can represent the epigenetic haplotype revealing a cell-to-cell methylation heterogeneity.
This study demonstraed that age-related reduction of free d-Asp levels in the mouse brain in dod knockout mice.
Ddo(-/-) mice display a significant reduction in schizophrenia related symptoms induced by phencyclidine. Increased D-aspartate in Ddo(-/-) animals affect the development of cortico-hippocampal connectivity networks potentially involved in schizophrenia.
Arg-216 and Arg-237 play crucial roles in the substrate specificity of DDO.
reports that the behavioral phenotype of the Dco-/- mouse is characterized by deficits in prepulse inhibition of the acoustic startle reflex and in motor coordination on the RotoRod
This study is the first to report robust age associations for DNA methylation in MYOF and DDO, both of which have plausible functional roles in aging
SNPSs R216Q and S308N reduce enzyme activity towards acidic d-amino acids, decrease the binding affinity for the coenzyme flavin adenine dinucleotide and decrease the temperature stability. Expression of DDO genes carrying the R216Q or S308N SNP substitutions may increase the d-aspartate content in humans and alter homeostasis of several other amino acids.
Characterization of the enzymatic and structural properties of human D-aspartate oxidase and comparison with those of the rat and mouse enzymes
There is a significant increase in DDO mRNA expression in the prefrontal cortex of patients with schizophrenia compared to controls.
data do not suggest that DDO plays a role in the etiology of schizophrenia in the German population
crystal of D-aspartate oxidase belonged to space group P2(1), with unit-cell parameters a = 79.38, b = 144.0, c = 80.46 A, beta = 101.1 degrees , and diffracted to 1.80 A resolution
newly identified D-aspartate oxidase-positive cells seem to actively degrade D-Asp to prevent an excess of D-Asp from exerting harmful effects on the respective functions of porcine tissues
DDO plays important roles to prevent undesirable off-target action of D-aspartate by strictly controlling local D-aspartate concentration in the pituitary and pineal glands
kinetic properties of DDO suggested that at high substrate concentrations, the FAD-reduced form of the enzyme also catalyzes the reaction: the oxidative half-reaction precedes the reductive one.
The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Two transcript variants encoding different isoforms have been found for this gene.
, d-aspartate oxidase
, D-aspartate oxidase, DDO
, aspartic oxidase