DHX58 Proteins

Protein Summary

Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.

Gene names and symbols associated with DHX58

• DEXH-box helicase 58 L homeolog (dhx58.L) antibody
• DExH-box helicase 58 (DHX58) antibody
• DExH-box helicase 58 (dhx58) antibody
• probable ATP-dependent RNA helicase DHX58 (LOC100566102) antibody
• DEXH (Asp-Glu-X-His) box polypeptide 58 (dhx58) antibody
• Show all gene names
• DEXH (Asp-Glu-X-His) box polypeptide 58 (Dhx58) antibody
• DEXH-box helicase 58 (Dhx58) antibody

• B430001I08Rik antibody
• D11LGP2 antibody
• D11Lgp2e antibody
• DHX58 antibody
• Lgp2 antibody
• Show all synonym aliases
• LPG2 antibody
• MGC82787 antibody
• RGD1310093 antibody
• RLR-3 antibody

Protein level used designations for DHX58

DEXH (Asp-Glu-X-His) box polypeptide 58 , probable ATP-dependent RNA helicase DHX58 , probable ATP-dependent RNA helicase DHX58-like , Probable ATP-dependent RNA helicase DHX58 , RIG-I-like receptor 3 , RIG-I-like receptor LGP2 , RLR , RNA helicase LGP2 , ortholog of mouse D11lgp2 , probable ATP-dependent helicase LGP2 , protein D11Lgp2 homolog , RIG-I-like receptor Lgp2 , protein D11Lgp2 , ATP-dependent RNA helicase DHX58