DHX58 Proteins

Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling.

Data Quality
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Type
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    Protein
Antigen
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Reactivity
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Application
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Host
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Binding Specificity
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Conjugate
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Protein Type
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Format
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4 Products
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityMouse (Murine)
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3136923
$9,371.15
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 60 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityHuman
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3092156
$9,371.15
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 60 Business Days
Recombinant Protein, Wheat germ (Source)
ISO
ReactivityHuman
Application AA, AP, ELISA, WB
Order details Cat. No. ABIN1351580
$414.29
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
Recombinant Protein, HEK-293 Cells (Source), Purity > 80 % as determined by SDS-PAGE and Coomassie blue staining
ReactivityHuman
Application AbP, Func, PI, STD
Order details Cat. No. ABIN2719466
$888.80
20 μg
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 11 Business Days
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DHX58 Protein Profile

Protein Summary

Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.

Gene names and symbols associated with DHX58

  • DEXH-box helicase 58 L homeolog (dhx58.L) antibody
  • DExH-box helicase 58 (DHX58) antibody
  • DExH-box helicase 58 (dhx58) antibody
  • probable ATP-dependent RNA helicase DHX58 (LOC100566102) antibody
  • DEXH (Asp-Glu-X-His) box polypeptide 58 (dhx58) antibody
  • DEXH (Asp-Glu-X-His) box polypeptide 58 (Dhx58) antibody
  • DEXH-box helicase 58 (Dhx58) antibody
  • B430001I08Rik antibody
  • D11LGP2 antibody
  • D11Lgp2e antibody
  • DHX58 antibody
  • Lgp2 antibody
  • LPG2 antibody
  • MGC82787 antibody
  • RGD1310093 antibody
  • RLR-3 antibody

Protein level used designations for DHX58

DEXH (Asp-Glu-X-His) box polypeptide 58 , probable ATP-dependent RNA helicase DHX58 , probable ATP-dependent RNA helicase DHX58-like , Probable ATP-dependent RNA helicase DHX58 , RIG-I-like receptor 3 , RIG-I-like receptor LGP2 , RLR , RNA helicase LGP2 , ortholog of mouse D11lgp2 , probable ATP-dependent helicase LGP2 , protein D11Lgp2 homolog , RIG-I-like receptor Lgp2 , protein D11Lgp2 , ATP-dependent RNA helicase DHX58

GENE ID SPECIES
444342 Xenopus laevis
742679 Pan troglodytes
100012544 Monodelphis domestica
100066316 Equus caballus
100171435 Pongo abelii
100403680 Callithrix jacchus
100468505 Ailuropoda melanoleuca
100499613 Oncorhynchus mykiss
100566102 Anolis carolinensis
100195148 Salmo salar
79132 Homo sapiens
80861 Mus musculus
303538 Rattus norvegicus
607803 Canis lupus familiaris
100524520 Sus scrofa
508378 Bos taurus
101121528 Ovis aries
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