DEXH (Asp-Glu-X-His) Box Polypeptide 58 Proteins (DHX58)

Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Additionally we are shipping DHX58 Antibodies (106) and DHX58 Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DHX58 79132 Q96C10
DHX58 80861 Q99J87
Rat DHX58 DHX58 303538  
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Top DHX58 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available

DHX58 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) Interaction Partners

Rainbow Trout (Oncorhynchus mykiss) DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) interaction partners

  1. MDA5 and LGP2 act as independent positive regulators of the IFN response in fish. the LGP2 variant with a deletion of 54 amino acids at the C terminus acts as a negative regulator for LGP2-elicited antiviral signaling.

Human DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) interaction partners

  1. Study demonstrated a tumor suppressor role of LGP2 in neuroblastoma (NB). LGP2 was effective in promoting poly (I:C)-induced NB suppression and cytoplasmic LGP2 can serve as an independent favorable prognostic factor in NB patients.

  2. genetic loss of LGP2 uncovers dsRNA-mediated RNAi albeit less strongly than complete loss of the IFN system

  3. Results indicate that pumilio RNA binding family member 1 (PUM1) is a negative regulator of RNA helicase LGP2 (LGP2), a master regulator of innate immunity genes expressed in a cascade fashion.

  4. study documents that recombinant measles virus produce defective interfering genomes that have high immunostimulatory properties via their binding to RIG-I and LGP2 proteins, both of which are cytosolic nonself RNA sensors of innate immunity.

  5. Data support a new model where an LGP2-MDA5 oligomer shuttles NS3 to the mitochondria to block antiviral signaling

  6. essential role in activating interferon signaling against hepatitis C virus (HCV) infection by promoting MDA5 recognition of HCV pathogen-associated molecular patterns

  7. This review briefly summarizes the RLR system, and focuses on the relationship between LGP2 and MDA5, describing in detail how these two proteins work together to detect foreign RNA and generate a fully functional antiviral response.

  8. L region antisense RNA of EMCV is a key determinant of innate immunity to the virus and represents an RNA that activates LGP2 associated MDA5 in virally-infected cells.

  9. LGP2 did not reveal significant single-SNP associations with multiple sclerosis risk.

  10. LGP2 increases the initial rate of MDA5-RNA interaction and regulates MDA5 filament assembly.

  11. Experiments with paramyxovirus V protein-insensitive proteins revealed that the primary outcome of LGP2 interference is suppression of its ability to synergize with MDA5.

  12. Data show that LGP2 is able to synergize with melanoma differentiation associated gene-5 (mda-5) to render cells to induction by poly(I:C), but did not enhance retinoic acid-inducible gene-I (RIG-I) to induce type I interferon in response to poly(I:C).

  13. results demonstrate previously unrecognized properties of LGP2 ATP hydrolysis and RNA interaction and provide a mechanistic basis for a positive regulatory role for LGP2 in antiviral signaling

  14. LGP2, a host protein induced during influenza A virus infection, downregulates the host antiviral IFN response

  15. Paramyxovirus 5 V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon beta induction.

  16. the present study shows the presence of RIG-1,MDA-5, and LGP-2 in the human upper airways, most prominently inthe epithelium.

  17. LGP2 functions as an inhibitor of the innate immune response triggered by Rabeis virus infection

  18. Data sugget that DeltaPsi(m) and MAVS are coupled at the same stage in the RLR antiviral signaling pathway.

  19. Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity.

  20. LGP2 competes with the kinase IKKi for a common interaction site on IPS-1, as an element of negative-feedback regulation of intracellular antiviral signaling.

Pig (Porcine) DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) interaction partners

  1. Study indicates that DHX58 is an important gene that is associated with the immune response in swine.

Cow (Bovine) DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) interaction partners

  1. Functional analysis of the human LGP2 ortholog.

DHX58 Protein Profile

Protein Summary

Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.

Gene names and symbols associated with DHX58

  • DEXH-box helicase 58 L homeolog (dhx58.L)
  • DExH-box helicase 58 (DHX58)
  • DExH-box helicase 58 (dhx58)
  • probable ATP-dependent RNA helicase DHX58 (LOC100566102)
  • DEXH (Asp-Glu-X-His) box polypeptide 58 (dhx58)
  • DEXH (Asp-Glu-X-His) box polypeptide 58 (Dhx58)
  • DEXH-box helicase 58 (Dhx58)
  • B430001I08Rik protein
  • D11LGP2 protein
  • D11Lgp2e protein
  • DHX58 protein
  • Lgp2 protein
  • LPG2 protein
  • MGC82787 protein
  • RGD1310093 protein
  • RLR-3 protein

Protein level used designations for DHX58

DEXH (Asp-Glu-X-His) box polypeptide 58 , probable ATP-dependent RNA helicase DHX58 , probable ATP-dependent RNA helicase DHX58-like , Probable ATP-dependent RNA helicase DHX58 , RIG-I-like receptor 3 , RIG-I-like receptor LGP2 , RLR , RNA helicase LGP2 , ortholog of mouse D11lgp2 , probable ATP-dependent helicase LGP2 , protein D11Lgp2 homolog , RIG-I-like receptor Lgp2 , protein D11Lgp2 , ATP-dependent RNA helicase DHX58

444342 Xenopus laevis
742679 Pan troglodytes
100012544 Monodelphis domestica
100066316 Equus caballus
100171435 Pongo abelii
100403680 Callithrix jacchus
100468505 Ailuropoda melanoleuca
100499613 Oncorhynchus mykiss
100566102 Anolis carolinensis
100195148 Salmo salar
79132 Homo sapiens
80861 Mus musculus
303538 Rattus norvegicus
607803 Canis lupus familiaris
100524520 Sus scrofa
508378 Bos taurus
101121528 Ovis aries
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