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Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Additionally we are shipping DRAP1 Proteins (9) and DRAP1 Kits (8) and many more products for this protein.
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Hypoxia actively represses transcription by inducing this protein and blocking preinitiation complex assembly.
physical cooperation between BTAF1 and NC2alpha in TBP regulation
The global distribution of DRAP1 on promoters was determined.
provide evidence that negative cofactor-2 (NC2) induces dynamic conformational changes in the TBP-DNA complex that allow it to escape and return to TATA-binding mode
heterodimerization with NC2alpha masks the nuclear localization signal in NC2beta, which prevents nuclear export of the NC2 complex
Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex.
, DR1-associated protein 1 (negative cofactor 2 alpha)
, dr1-associated protein 1
, negative co-factor 2-alpha
, negative cofactor 2 alpha