DRAP1 antibody (AA 50-150)

Catalog No. ABIN7266844

This Rabbit Polyclonal antibody specifically detects DRAP1 in WB. It exhibits reactivity toward Human.

Quick Overview for DRAP1 antibody (AA 50-150) (ABIN7266844)

Target: DRAP1 (DR1-Associated Protein 1 (Negative Cofactor 2 Alpha) (DRAP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DRAP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DRAP1 Antibody

Binding Specificity: AA 50-150

Purpose: DRAP1 Rabbit pAb

Sequence: LKKACQVTQS RNAKTMTTSH LKQCIELEQQ FDFLKDLVAS VPDMQGDGED NHMDGDKGAR RGRKPGSGGR KNGGMGTKSK DKKLSGTDSE QEDESEDTDT D

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 50-150 of human DRAP1 (NP_006433.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DRAP1

Target: DRAP1 (DR1-Associated Protein 1 (Negative Cofactor 2 Alpha) (DRAP1))

Alternative Name: DRAP1

Background: Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008],NC2-alpha,DRAP1,Epigenetics & Nuclear Signaling,Transcription Factors,DRAP1

Gene ID: 10589

UniProt: Q14919