anti-Desmin (DES) Antibodies

DES encodes a muscle-specific class III intermediate filament. Additionally we are shipping Desmin Kits (72) and Desmin Proteins (33) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DES 1674 P17661
DES 64362 P48675
DES 13346 P31001
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Top anti-Desmin Antibodies at antibodies-online.com

Showing 10 out of 444 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IHC (p), WB Anti-Desmin antibody (monoclonal), IHC(P) IHC(P): Rat Cardiac Muscle Tissue Anti-Desmin antibody (monoclonal), IHC(P): Rat Cardiac Muscle Tissue 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (fro), IHC (p), WB Immunohistochemistry-Paraffin: Desmin Antibody [ABIN43049740] - IHC analysis of Desmin in paraffin embedded and frozen E8-E11 mouse embryos. Image courtesy of product review submitted by Tara Rasmussen. Immunohistochemistry-Paraffin: Desmin Antibody [ABIN43049740] - Human skeletal muscle stained with anti-desmin antibody. 1 mL Log in to see 7 to 9 Days
$585.06
Details
Human Mouse Un-conjugated IHC (fro), IHC, WB 0.1 mg Log in to see 5 to 7 Days
$376.36
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-DES Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Human Muscle Host:  Rabbit  Target Name:  DES  Sample Type:  Human Fetal Heart  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (fro), IHC (p), WB Anti-Desmin Picoband antibody,  IHC(F): Rat Cardiac Muscle Tissue Anti-Desmin Picoband antibody,  All lanes: Anti Desmin  at 0.5ug/ml WB: Recombinant Human Desmin Protein 0.5ng Predicted bind size: 36KD Observed bind size: 36KD 100 μg Log in to see 4 to 6 Days
$280.00
Details
Chicken Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat kidney tissue labeled with Anti-Desmin Polyclonal Antibody, Unconjugated (ABIN736566) at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse heart tissue labeled with Anti-Desmin Polyclonal Antibody, Unconjugated (ABIN736566) at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$318.45
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN334386 (0.2µg/ml) staining of Human Skeletal Muscle lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Rabbit Un-conjugated IHC (p), WB IHC-P Image Desmin antibody detects Desmin protein at cytosol on mouse skeletal muscle by immunohistochemical analysis. Sample: Paraffin-embedded mouse skeletal muscle. Desmin antibody , dilution: 1:500. WB Image Desmin antibody detects Desmin protein by western blot analysis. A. 30 μg Rat2 whole cell lysate/extract 10 % SDS-PAGE Desmin antibody , dilution: 1:1000 100 μL Log in to see 1 to 2 Days
$358.60
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-DES Antibody Titration:  5.0ug/ml  Positive Control:  Jurkat cell lysate Host:  Mouse  Target Name:  DES  Sample Tissue:  Mouse Skeletal Muscle  Antibody Dilution:  1ug/ml 100 μL Log in to see 2 to 3 Days
$229.00
Details
Chicken Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of Desmin staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Desmin staining in human muscle formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details

DES Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Desmin Antibodies

  1. Human Polyclonal Desmin Primary Antibody for IHC (fro), IHC (p) - ABIN3043265 : Jiang, Xu, Zhu, Chen, Qian, Qiao, Yang, Wang, Chen: Histological type of oncogenity and expression of cell cycle genes in tumor cells from human mesenchymal stem cells. in Oncology reports 2006 (PubMed)
    Show all 17 Pubmed References

  2. Human Monoclonal Desmin Primary Antibody for IHC (p), WB - ABIN3043640 : Longxi, Buwu, Yuan, Sinan: Expression of p53 in the effects of artesunate on induction of apoptosis and inhibition of proliferation in rat primary hepatic stellate cells. in PLoS ONE 2011 (PubMed)
    Show all 17 Pubmed References

  3. Human Monoclonal Desmin Primary Antibody for IHC (fro), IHC - ABIN335360 : Dispersyn, Geuens, Ver Donck, Ramaekers, Borgers: Adult rabbit cardiomyocytes undergo hibernation-like dedifferentiation when co-cultured with cardiac fibroblasts. in Cardiovascular research 2001 (PubMed)
    Show all 8 Pubmed References

  4. Human Polyclonal Desmin Primary Antibody for ICC, IF - ABIN4304974 : Rasmussen, Kweon, Diekmann, Belema-Bedada, Song, Bowlin, Shi, Ferdous, Li, Kyba, Metzger, Koyano-Nakagawa, Garry: ER71 directs mesodermal fate decisions during embryogenesis. in Development (Cambridge, England) 2011 (PubMed)
    Show all 8 Pubmed References

  5. Chicken Polyclonal Desmin Primary Antibody for IF (p), IHC (p) - ABIN736566 : Luo, Wu, Ye, Li, Hao, Kong, Zheng, Lin, Nie, Zhang: The transient expression of miR-203 and its inhibiting effects on skeletal muscle cell proliferation and differentiation. in Cell death & disease 2014 (PubMed)
    Show all 6 Pubmed References

  6. Human Monoclonal Desmin Primary Antibody for IHC, ELISA - ABIN965993 : Shardonofsky, Capetanaki, Boriek: Desmin modulates lung elastic recoil and airway responsiveness. in American journal of physiology. Lung cellular and molecular physiology 2006 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal Desmin Primary Antibody for IHC (fp), IHC (fro) - ABIN965994 : Geisler, Weber: Purification of smooth-muscle desmin and a protein-chemical comparison of desmins from chicken gizzard and hog stomach. in European journal of biochemistry / FEBS 1981 (PubMed)
    Show all 3 Pubmed References

  8. Human Monoclonal Desmin Primary Antibody for IHC, ELISA - ABIN969477 : Huang, Li, Foster, Lemanski, Dube, Zhang, Lemanski: Protein kinase C-mediated desmin phosphorylation is related to myofibril disarray in cardiomyopathic hamster heart. in Experimental biology and medicine (Maywood, N.J.) 2002 (PubMed)
    Show all 2 Pubmed References

  9. Cat (Feline) Monoclonal Desmin Primary Antibody for ICC, IF - ABIN257974 : Agarwal, van den Born, van Goor, Navis, Gans, Bakker: Renoprotective effects of long-term oral nicotine in a rat model of spontaneous proteinuria. in American journal of physiology. Renal physiology 2012 (PubMed)
    Show all 2 Pubmed References

  10. Human Polyclonal Desmin Primary Antibody for ELISA, IHC - ABIN4304973 : Raghuvanshi, Reed, Blaner, Harrison: Cellular localization of β-carotene 15,15' oxygenase-1 (BCO1) and β-carotene 9',10' oxygenase-2 (BCO2) in rat liver and intestine. in Archives of biochemistry and biophysics 2015 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Desmin Interaction Partners

Zebrafish Desmin (DES) interaction partners

  1. Desmin intermediate filaments are required for normal active force generation.

  2. Desmin distribution during muscle maturation changes from dispersed aggregates to a perinuclear concentration to striated (show NSDHL Antibodies) afterwards.

Human Desmin (DES) interaction partners

  1. A novel mutation (c.679 C>T /p.R227C) in exon 3 of DES was identified and cosegregated with the affected members of a Chinese family with isolated Dilated cardiomyopathy (DCM) phenotypes (left ventricle and left atrial diameters).

  2. Desmin, Glial Fibrillary Acidic Protein (show GFAP Antibodies), Vimentin (show VIM Antibodies), and Peripherin (show PRPH Antibodies) are type III intermediate filaments that have roles in health and disease [review]

  3. Phenotypic expression of a novel desmin gene mutation: hypertrophic cardiomyopathy followed by systemic myopathy.

  4. Using a combination of co-sedimentation centrifugation, viscometric assays and electron microscopy of negatively stained filaments to analyse the in vitro assembly of desmin filaments, this study shows that the binding of CRYAB (show CRYAB Antibodies) to desmin is subject to its assembly status, to the subunit organization within filaments formed and to the integrity of the C-terminal tail domain of desmin.

  5. Targeted sequencing revealed trigenic mutations: c.700G>A/p.E234K in DES, c.2966G>A/p.R989H in MYPN (show MYPN Antibodies), and c.5918G>C/p.R1973P in CACNA1C (show CACNA1C Antibodies) in a family of hypertrophic cardiomyopathy with early repolarization and short QT syndrome.

  6. demonstrate that the expression of mutant desmin causes disruption of the extrasarcomeric desmin cytoskeleton and extensive mitochondrial abnormalities regarding subcellular distribution, number and shape

  7. Mutation in the Core Structure of Desmin Intermediate Filaments Affects Myoblast Elasticity

  8. Data show that the filament elongation of both desmin and keratin K8/K18 (show KRT18 Antibodies) proceeds very similar to that of vimentin (show VIM Antibodies).

  9. Cdk1 (show CDK1 Antibodies)-induced desmin phosphorylation is required for efficient separation of desmin-IFs and generally detected in muscular mitotic cells in vivo.

  10. Desmin, Lamin A/C, MMP9, and histone H4 were upregulated in the placental villi of women experiencing early pregnancy loss.

Mouse (Murine) Desmin (DES) interaction partners

  1. Moderate MnSOD (show SOD2 Antibodies) and/or catalase (show CAT Antibodies) overexpression in desmin-null hearts leads to a marked decrease in intracellular reactive oxygen species, ameliorates mitochondrial and other ultrastructural defects, minimizes myocardial degeneration and leads to a significant improvement of cardiac function.

  2. R349P mutant desmin-related remodeling of the 3D myofibrillar architecture during aging, which provides a structural basis for the progressive muscle weakness.

  3. demonstrate that the expression of mutant desmin causes disruption of the extrasarcomeric desmin cytoskeleton and extensive mitochondrial abnormalities regarding subcellular distribution, number and shape

  4. The disease-mutant desmin variants E245D and T453I exhibited increased binding affinity for nebulette (show NEBL Antibodies), delayed filament assembly kinetics, and caused significant weakening of networks.

  5. desmin and alphaBeta-crystallin are localized at sarcoplasmic reticulum (SR)-mitochondria-associated membranes (MAMs), where they interact with VDAC, Mic60 - the core component of mitochondrial contact site and cristae organizing system (MICOS) complex - and ATP synthase, suggesting that these associations could be crucial in mitoprotection at different levels.

  6. Complete lack or markedly decreased expression of mutant R349P desmin impairs the structural and functional integrity of neuromuscular endplates.

  7. Cdk1 (show CDK1 Antibodies)-induced desmin phosphorylation is required for efficient separation of desmin-IFs and generally detected in muscular mitotic cells in vivo.

  8. the coordinated up-regulations of desmin and alpha- actinin (show ACTN1 Antibodies) specifically in the early stage of diastolic heart failure mouse models indicate a novel myocardial response.

  9. E413K mutation induces desmin network disorganization, desmin aggregate formation and alters the traction forces generation of single myoblasts.

  10. This study identifies desmin as a new Asb2b target for proteasomal degradation in cardiomyocytes and suggests that accumulation of desmin could contribute to UPS impairment in Hypertrophic cardiomyopathy mice and patients

Cow (Bovine) Desmin (DES) interaction partners

  1. Results show that expression of desmin increased during the late fattening stage of of hanwoo steers and it contributes to the muscle contractile apparatus.

Desmin (DES) Antigen Profile

Protein Summary

This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.

Gene names and symbols associated with anti-Desmin (DES) Antibodies

  • desmin (DES) antibody
  • desmin, gene 1 L homeolog (des.1.L) antibody
  • desmin, gene 1 (des.1) antibody
  • desmin (des) antibody
  • desmin a (desma) antibody
  • desmin (Des) antibody
  • desmin b (desmb) antibody
  • desmin, gene 1 S homeolog (des.1.S) antibody
  • desmin, gene 2 S homeolog (des.2.S) antibody
  • cb290 antibody
  • cmd1i antibody
  • CSM1 antibody
  • CSM2 antibody
  • des antibody
  • des-a antibody
  • des-b antibody
  • desm antibody
  • desmin antibody
  • fb59a12 antibody
  • LGMD2R antibody
  • LOC100220724 antibody
  • MGC52614 antibody
  • MGC75911 antibody
  • MGC80853 antibody
  • wu:fb59a12 antibody
  • wu:fc11d08 antibody
  • zgc:109859 antibody
  • zgc:154009 antibody

Protein level used designations for anti-Desmin (DES) Antibodies

desmin , desmin, gene 1 , desmin-like , intermediate filament protein , muscle-specific intermediate filament desmin , fc11d08

GENE ID SPECIES
100059397 Equus caballus
100137488 Papio anubis
446868 Xenopus laevis
394739 Xenopus (Silurana) tropicalis
470657 Pan troglodytes
100136041 Oncorhynchus mykiss
100220724 Taeniopygia guttata
100402007 Callithrix jacchus
30148 Danio rerio
100586972 Nomascus leucogenys
395906 Gallus gallus
1674 Homo sapiens
64362 Rattus norvegicus
497091 Canis lupus familiaris
13346 Mus musculus
101097010 Felis catus
280765 Bos taurus
101117308 Ovis aries
100328890 Oryctolagus cuniculus
396725 Sus scrofa
100733478 Cavia porcellus
101837949 Mesocricetus auratus
768287 Danio rerio
379869 Xenopus laevis
733312 Xenopus laevis
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