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DVL3 is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. Additionally we are shipping DVL3 Antibodies (85) and and many more products for this protein.
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Different Dvl (show DVL2 Proteins) proteins (Dvl1 (show DVL1 Proteins), Dvl2 (show DVL2 Proteins), Dvl3) and the composition of dishevelled (show DVL2 Proteins)-beta-arrestin protein complexes contribute to the specific activation of individual branches of Wnt (show WNT2 Proteins) signaling in Xenopus gastrulation.
Data show that maternal Dvl2 and 3 are required for convergence extension movements downstream of the dorsally localized signaling pathway activated by Xnr3, but not downstream of the pathway activated by activin.
Dvl-2 (show DVL2 Proteins) and Dvl-3 have a widespread distribution in both the olfactory epithelium and olfactory bulb
Dvl3 is important for IPMK (show IPMK Proteins) to access substrates and generate IP5, activating down-stream signaling.
Dishevelled (show DVL2 Proteins)-KSRP (show KHSRP Proteins) complex operates in Wnt (show WNT2 Proteins) regulation of beta-catenin (show CTNNB1 Proteins), functioning post-transcriptionally upon CTNNB1 (show CTNNB1 Proteins) mRNA stability.
Dvl2 (show DVL2 Proteins) and Dvl3 proteins were found to be localized to the apical side of the node cells, and their location was polarized to the posterior side of the cells before the posterior positioning of the basal body.
As embryos reach blastocyst stage, Dishevelled 2 (show DVL2 Proteins) becomes increasingly associated with cell membrane in trophectoderm cells, while at E4.5, Dishevelled 3 is highly enriched in the cytoplasm of inner cell mass cells.
The expression of Dishevelleds in mammalian cells provide an estimate of the relative cellular abundance of each Dvl (show DVL1 Proteins).
G alpha o (show GNAO1 Proteins) mediates WNT (show WNT2 Proteins)-JNK (show MAPK8 Proteins) signaling through dishevelled 1 (show DVL1 Proteins) and 3, RhoA (show RHOA Proteins) family members, and MEKK 1 (show MAP2K1 Proteins) and 4 in mammalian cells
Dvl1 (show DVL1 Proteins), Dvl2 (show DVL2 Proteins) and Dvl3 are functionally redundant in cardiac outflow tract, cochlea, and neural tube development.
Dvl3 is overexpressed in human HCCs (show HCCS Proteins). The NP-Dvl3 is the more stable and active form of the protein and enhances HCC (show FAM126A Proteins) stemness.
we found that Wnt3a (show WNT3A Proteins) treatment rapidly induces hyperphosphorylation and stabilization of Dvl2 (show DVL2 Proteins) and Dvl3. Our findings suggest a model of positive regulation of PKCzeta (show PRKCZ Proteins)-mediated Dvl (show DVL2 Proteins) signaling activity, to produce a strong and sustained response to Wnt3a (show WNT3A Proteins) treatment by stabilizing Dvl (show DVL2 Proteins) protein levels.
Studied and identified candidate biomarkers of biochemical recurrence (BCR (show BCR Proteins)) of prostate adenocarcinoma by integrating reverse-phase protein array (RPPA) and mRNA datafrom The Cancer Genome Atlas (TCGA). Found DVL3 was expressed in patients with a higher risk of BCR (show BCR Proteins). DVL3 may be a novel and easily applicable recurrence predictor of localised prostate adenocarcinoma.
two mutually exclusive functions of the DEP domain in Wnt (show WNT2 Proteins) signal transduction - binding to Frizzled to recruit Dishevelled (show DVL2 Proteins) to the receptor complex, is reported.
Genetic changes between MLH1 (show MLH1 Proteins) and MSH2 were significantly positively correlated (p = 0.032). We also noted a positive correlation between genetic changes of MSH2 and DVL3 genes (p = 0.034).
Data show that dishevelled (show DVL2 Proteins) proteins DVL1 (show DVL1 Proteins), 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).
Kif26b, together with Dvl3/Daam1 (show DAAM1 Proteins), initiates cell polarity through the control of planar cell polarity-signaling pathway-dependent activation in endothelial cells.
DVL3 transcripts decreased in individuals with major depressive disorder
we demonstrate that normally ALFY attenuates the canonical Wnt (show WNT2 Proteins) signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 (show DVL1 Proteins) or Dvl2 (show DVL2 Proteins).
All variants in DVL3 result in a -1 frameshift, indicating that these highly specific alterations might be a common cause of dominant Robinow syndrome.
This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.
DSH homolog 3
, dishevelled, dsh homolog 3
, segment polarity protein dishevelled homolog DVL-3
, dishevelled, dsh homolog 3 (Drosophila)
, dishevelled 3 (homologous to Drosophila dsh)
, dishevelled 3, dsh homolog
, dishevelled 3
, dishevelled, dsh homolog 3a