anti-Distal-Less Homeobox 5 (DLX5) Antibodies

DLX5 encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. Additionally we are shipping Distal-Less Homeobox 5 Kits (15) and Distal-Less Homeobox 5 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DLX5 1749 P56178
DLX5 13395 P70396
DLX5 25431 P50575
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Top anti-Distal-Less Homeobox 5 Antibodies at antibodies-online.com

Showing 10 out of 110 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB Human Lung WB Suggested Anti-DLX5 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Transfected 293T 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB Immunohistochemistry with Thymus tissue at an antibody concentration of 5µg/ml using anti-DLX5 antibody (ARP31607_P050) WB Suggested Anti-DLX5 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  THP-1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, IHC, WB EB09284 (1µg/ml) staining of Human Bone Marrow lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$429.84
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-DLX5 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:312500  Positive Control:  Human Placenta Host:  Mouse  Target Name:  DLX5  Sample Tissue:  Mouse Skeletal Muscle  Antibody Dilution:  1ug/ml 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of DLX5 (arrow) using rabbit polyclonal DLX5 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the DLX5 gene. DLX5 Antibody (Center)  western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the DLX5 antibody detected the DLX5 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Cow Rabbit Un-conjugated IHC, WB Human Heart Human Liver 100 μL Log in to see 2 to 3 Days
$229.00
Details
Chicken Rabbit Un-conjugated IC, IF, IP, IHC, WB Immunofluorescent analysis of DLX5 staining in Raw264.7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of DLX5 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HeLa/293/COLO205 cells, using DLX5 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using DLX5 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p), WB Anti-DLX5 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN962651 concentration 41396 ug/ml. Anti-DLX5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: Dlx5 Antibody [NBP1-85793] - Lane 1: Marker [kDa] 220, 112, 84, 47, 32, 26, 17.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp Immunohistochemistry-Paraffin: Dlx5 Antibody [NBP1-85793] - Staining of human rectum shows strong nuclear and moderate cytoplasmic positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details

Top referenced anti-Distal-Less Homeobox 5 Antibodies

  1. Human Polyclonal DLX5 Primary Antibody for ELISA, WB - ABIN451750 : Lee, Kim, Kim, Park, Kang, Kyung, Sung, Wozney, Kim, Ryoo: BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression. in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal DLX5 Primary Antibody for ELISA, WB - ABIN541988 : Tan, Timakhov, Rao, Altomare, Xu, Liu, Gao, Jhanwar, Di Cristofano, Wiest, Knepper, Testa: A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice. in Cancer research 2008 (PubMed)

  3. Human Polyclonal DLX5 Primary Antibody for ICC, IF - ABIN4305382 : Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013 (PubMed)

More Antibodies against Distal-Less Homeobox 5 Interaction Partners

Human Distal-Less Homeobox 5 (DLX5) interaction partners

  1. Our data suggest that loss of DLX5, TLX1 and HOXA10 expression in late gestation is required for proper placental differentiation and function.

  2. Our results in mice suggest that long-range DLX5 enhancer elements located in the human SLC25A13 gene may underlie the sensorineural hearing loss that is sometimes associated with SHFM1.

  3. These results indicate activation of DLX5 and RUNX2 via its distal promoter represents a unique feature of GFs, and is important for ECM regulation. Down-regulation of these transcription factors in PAFs could be associated with their property to degrade collagen, which may impact on the process of periodontitis.

  4. these findings indicate that, in MSCs, DLX5 is a master regulator of osteogenesis. Furthermore, tanshinone IIA may be valuable for stem cell-based therapies of certain bone diseases.

  5. As a result of disturbed imprinting, the upregulated DLX5 affects trophoblast proliferation in preeclampsia.

  6. These data indicate that certain missense mutations diminish the ability of the Dlx5 homeodomain to recognize and bind target DNAs, and they likely destabilize the formation of functional complexes.

  7. In cells grown on titanium support, DLX5 and RUNX1 were respectively upregulated (+3.12-fold) and downregulated (-2.14-fold)

  8. Absent expression of the osteoblast-specific maternally imprinted genes, DLX5 and DLX6, causes split hand/split foot malformation type I.

  9. Heterozygous DLX5 nonsense mutation c.G115T(p.E39X) associated with isolated split-hand/foot malformation with reduced penetrance and variable expressivity in two unrelated Polish families.

  10. A novel heterozygous mutation in exon 3 of DLX5 found in the family members with SHFM1 phenotype.

  11. Genome sequencing of the deletion breakpoints showed that the DLX5 and DLX6 genes are disomic but the putative DYNC1I1 exon 15 and 17 enhancers are deleted.

  12. The duplicated region harbors only DLX5 and DLX6, which are known for their role in SHFM1.

  13. The strongest evidence for altered methylation patterns in shiftworkers was observed for DLX5 gene.

  14. Cyclic tensile stress may induce differentiation of periodontal ligament stem cells towards mineralized tissue cells by promoting Dlx5 mRNA expression and decreasing Msx2 expression.

  15. Two patients that have in common a p63-Dlx5/Dlx6 pathway dysregulation.

  16. the first intragenic DLX5 mutation in split hand and foot malformation is found; a potential dual role for DLX5 in limb development is suggested

  17. DLX5 is significantly increased in heart tissue from calcific aortic valve patients compared to controls.

  18. MDA-MB-231 breast neoplasms did not express DLX5 but the resulting bone/lung metastases did.

  19. Data suggest that DLX5 plays a significant role in the pathogenesis of some ovarian cancers by enhancing IRS-2-AKT signaling.

  20. p63 binds to an enhancer element in the SHFM1 locus and this element controls expression of DLX6 and DLX5 which are important for limb development.

Mouse (Murine) Distal-Less Homeobox 5 (DLX5) interaction partners

  1. T-614 promotes osteoblastic differentiation by increasing the expression of Osterix and Dlx5.

  2. Results indicate that Dlx5 and Runx2 are critical factors for the upregulated Osterix expression in shPP2A cells, which is considered to be important for the accelerated osteoblast differentiation in these cells.

  3. FGF10 pathway is downregulated in Dlx5(-/-) mice, and activation of FGF10 signaling rescues cranial neural crest cell proliferation and myogenic differentiation.

  4. High DLX5 expression is associated with T-cell lymphomagenesis.

  5. Both transient and stable expression of Necdin induced osteoblast-specific markers in an osteogenic cell line through formation of a complex with distal-less Homeobox 5 (Dlx5) and Runx2 promoter activation.

  6. DLX5 and DLX6 reciprocally inhibit BMP/H2-mediated H1 enhancer regulation in mandible embryonic development.

  7. We found that in Dlx5;6 DKO limbs, the AER expresses lower levels of Wnt5a, shows scattered beta-catenin responsive cells and altered basolateral and planar cell polarity (PCP).

  8. Dlx5 and Dlx6 expression determines uterine architecture and adenogenesis and is needed for implantation

  9. The results presented here indicate that loss of Dlx5 causes a down-modulation of miR-9 and of miR-200-class, which results in the over-expression of the Foxg1 protein.

  10. Lck-Dlx5 mice develop T-ALLs that consistently acquire overexpression of Myc and activation of Akt.

  11. Study demonstrated a novel role of miR-124 and Dlx5 in regulating the differentiation of mesenchymal stem cells toward the myogenic lineage, that is, miR-124 inhibits myogenic differentiation partially through targeting Dlx5 expression.

  12. Mash1 is required for the expression of GAD67 and Dlx5 in taste bud cells.

  13. Dlx5 and Mef2 directly bound to the runx2 enhancer, and the binding sites were required for the osteoblast-specific expression

  14. the prethalamic factors Dlxs upregulated by Ascl1/Helt deficiency play unique roles in regulating thalamic progenitor specification.

  15. Results show that DLX5, p63, Pin1 and FGF8 participate to the same time- and location-restricted regulatory loop essential for apical ectodermal ridge stratification, hence for normal patterning and skeletal morphogenesis of the limb buds.

  16. The Edn1/Ednra signaling regulates neural crest differentiation to ensure the proper patterning of pharyngeal arch arteries, which is independent of the mechanism mediated by Dlx5/Dlx6.

  17. Data show that Dlx5 and Msx2 play a critical role in controlling cranial neural tube morphogenesis by regulating cell adhesion via the ephrinA5 and EphA7 pathway.

  18. in AER cells and, at later stages, in the limb mesoderm the regulation of by Dlx5 and Dlx6 occurs also cell autonomously

  19. allelic reduction of Dlx5 and Dlx6 in the mouse results in a POI-like phenotype, characterized by reduced fertility and early follicular exhaustion.

  20. Dlx5, Msx2, and Runx2 enhancers exhibit a dual requirement for TCF/LEF1 and Smad binding element (SBE) sites that mediate synexpression of the three genes during osteoblast differentiation.

Xenopus laevis Distal-Less Homeobox 5 (DLX5) interaction partners

  1. Retinoic acid treatment leads to a progressive loss of Dlx5 and Dlx6 expression in the first pharyngeal arch.

Pig (Porcine) Distal-Less Homeobox 5 (DLX5) interaction partners

  1. Imprinting analysis shows that DLX5 is maternally expressed in some organs and tissues but not imprinted in others.

Zebrafish Distal-Less Homeobox 5 (DLX5) interaction partners

  1. Data indicate that retinoic acid (RA) induces the expression patterns of genes normally expressed in the posterior tooth-forming region, such as pitx2 and dlx2b.

  2. Zebrafish dlx2b can drive reporter expression in oral teeth of the related characiform Astyanax mexicanus.

Distal-Less Homeobox 5 (DLX5) Antigen Profile

Protein Summary

This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation.

Gene names and symbols associated with DLX5

  • distal-less homeobox 5 (DLX5) antibody
  • distal-less homeobox 5 (Dlx5) antibody
  • distal-less homeobox 5 L homeolog (dlx5.L) antibody
  • distal-less homeobox 5 (dlx5) antibody
  • distal-less homeobox 2b (dlx2b) antibody
  • AI385752 antibody
  • dll3 antibody
  • dlx5 antibody
  • MGC69418 antibody
  • RDLX antibody
  • SHFM1D antibody
  • X-dll3 antibody

Protein level used designations for DLX5

distal-less homeo box 5 , homeobox protein DLX-5 , split hand/foot malformation type 1 with sensorineural hearing loss , DLX-3 , homeobox protein DLX-3 , cDlx , XDLL-3 , homeobox protein DLL-3 , putative transcription factor DLL3 , distal-less homeobox 5 , distal-less homeobox protein 5 , DLX-5 , distal-less homeobox gene 5 , distal-less homeobox protein 2b , homeobox protein Dlx2b

GENE ID SPECIES
1749 Homo sapiens
13395 Mus musculus
25431 Rattus norvegicus
373969 Gallus gallus
399265 Xenopus laevis
447997 Xenopus (Silurana) tropicalis
463554 Pan troglodytes
482313 Canis lupus familiaris
507415 Bos taurus
697853 Macaca mulatta
100008630 Oryctolagus cuniculus
100286863 Sus scrofa
30557 Danio rerio
101119298 Ovis aries
100736137 Cavia porcellus
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