DLX5 antibody (Internal Region)

Catalog No. ABIN6258115

Cited in 1 publication. The Rabbit Polyclonal anti-DLX5 antibody (ABIN6258115) specifically detects DLX5 in WB, IHC, IF and ICC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for DLX5 antibody (Internal Region) (ABIN6258115)

Target: DLX5 (Distal-Less Homeobox 5 (DLX5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLX5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-DLX5 Antibody

Binding Specificity: Internal Region

Purpose: DLX5 Antibody

Specificity: DLX5 Antibody detects endogenous levels of total DLX5.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human DLX5, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

References for anti-DLX5 antibody (ABIN6258115)

Miwa, Ito, Ohta: "Tsukushi is essential for the formation of the posterior semicircular canal that detects gait performance." in: Journal of cell communication and signaling, (2021) (PubMed).

Target Details for DLX5

Target: DLX5 (Distal-Less Homeobox 5 (DLX5))

Alternative Name: DLX5

Background:

Description: Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding.

Gene: DLX5

Molecular Weight: 32 kDa

Gene ID: 1749

UniProt: P56178