Protein Summary

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.

Gene names and symbols associated with DCLK1

• doublecortin like kinase 1 (DCLK1) antibody
• doublecortin-like kinase 1a (dclk1a) antibody
• serine/threonine-protein kinase DCLK1 (LOC587664) antibody
• doublecortin-like kinase 2 (dclk2) antibody
• serine/threonine-protein kinase DCLK1 (LOC100539645) antibody
• Show all gene names
• doublecortin-like kinase 1 (Dclk1) antibody
• doublecortin-like kinase 1 (DCLK1) antibody
• doublecortin like kinase 1 (Dclk1) antibody

• 1700113D08Rik antibody
• 2810480F11Rik antibody
• AI836758 antibody
• Ania4 antibody
• CL1 antibody
• Show all synonym aliases
• Click-I antibody
• CLICK1 antibody
• Cpg16 antibody
• Dcamkl1 antibody
• DCDC3A antibody
• Dcl antibody
• Dclk antibody
• dclk1 antibody
• MGC145348 antibody
• mKIAA0369 antibody
• wu:fc51f11 antibody
• zgc:153709 antibody

Protein level used designations for DCLK1

doublecortin-like kinase 1 , doublecortin and CaM kinase-like 1 , doublecortin and calcium/calmodulin-dependent protein kinase-like 1 , serine/threonine-protein kinase DCLK1 , doublecortin-like kinase 2 , serine/threonine-protein kinase DCLK1-like , doublecortin domain-containing protein 3A , doublecortin-like and CAM kinase-like 1 , CLICK-I beta , double cortin and calcium/calmodulin-dependent protein kinase-like 1