DCLK1 antibody

Catalog No. ABIN1678754

The Rabbit Monoclonal anti-DCLK1 antibody is suitable to detect DCLK1 in samples from Human. It has been validated for WB.

Quick Overview for DCLK1 antibody (ABIN1678754)

Target: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This DCLK1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DCLK1 Antibody

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human DCAMKL1/DCLK1

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DCLK1

Target: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Alternative Name: DCLK1

Background: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010],CL1, CLICK1, DCAMKL1, DCDC3A, DCLK,Kinase,Neuroscience,Signal Transduction,DCLK1

Molecular Weight: 82 kDa

Gene ID: 9201

UniProt: O15075