anti-Dual Oxidase Maturation Factor 1 (DUOXA1) Antibodies

Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. Additionally we are shipping DUOXA1 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DUOXA1 90527 Q1HG43
DUOXA1 213696 Q8VE49
DUOXA1 311374  
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Top anti-DUOXA1 Antibodies at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL 2 to 3 Days
$289.00
Details
Dog Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Goat Un-conjugated ELISA, WB Western blot testing of human HeLa cell lysate and NIP antibody at 0.03ug/ml. Predicted molecular weight: ~36/26kDa (isoforms 1/2). 100 μg 2 to 3 Days
$452.38
Details
Human Mouse Un-conjugated WB Western Blot analysis of DUOXA1 expression in transfected 293T cell line by DUOXA1 MaxPab polyclonal antibody.Lane 1: NIP transfected lysate(32.89 KDa).Lane 2: Non-transfected lysate. 50 μg 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated WB Western Blot showing DUOXA1 antibody used at a concentration of 1 ug/ml against Jurkat Cell Lysate 50 μg 9 to 11 Days
$449.29
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB   100 μL 3 to 7 Days
$327.80
Details
Human Rabbit Biotin ELISA   100 μg 11 to 16 Days
$464.30
Details
Human Rabbit FITC ELISA   100 μg 11 to 16 Days
$464.30
Details
Human Rabbit HRP ELISA   100 μg 11 to 16 Days
$464.30
Details
Human Rabbit Un-conjugated ELISA, IF/ICC   100 μg 11 to 16 Days
$464.30
Details

Top referenced anti-DUOXA1 Antibodies

  1. Human Polyclonal DUOXA1 Primary Antibody for WB - ABIN530004 : Little, Sham, Hristova, Danyal, Heppner, Bauer, Sipsey, Habibovic, van der Vliet: DUOX1 silencing in lung cancer promotes EMT, cancer stem cell characteristics and invasive properties. in Oncogenesis 2016 (PubMed)

More Antibodies against DUOXA1 Interaction Partners

Human Dual Oxidase Maturation Factor 1 (DUOXA1) interaction partners

  1. Study shows that DUOXA1 is overexpressed in platinum-resistant ovarian cancer (OC) cells, resulting in over production of reactive oxygen species (ROS). Elevated ROS level sustains the activation of ATR-Chk1 pathway, leading to resistance to cisplatin in OC cells. Clinical studies also confirm the activation of ATR and DOUXA1 in OC patients, and elevated DOUXA1 or ATR-Chk1 pathway correlates with poor prognosis.

  2. We analyzed the expression of NADPH oxidase isoforms and found both A431 and HaCaT cells to express the calcium-sensitive NADPH oxidase, Dual oxidase 1 (Duox1) and its protein partner Duox activator 1 (DuoxA1).Our observations provide evidence for a new signaling paradigm in which changes of intracellular calcium concentration are transformed into redox signals through the calcium-dependent activation of Duox1.

  3. DUOXA1 transient overexpression affected the cell-cell adhesion by modulating the actin cytoskeleton

  4. Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.

Mouse (Murine) Dual Oxidase Maturation Factor 1 (DUOXA1) interaction partners

  1. The proliferation and migration of granule cells was delayed after P15 in Duoxa-/- mice. However, these changes disappeared by P25. Although the cerebellar structure of Duoxa-/- mice was not significantly different from that of Wt mice at P25, motor coordination was impaired. It was also found that the amplitude of paired-pulse facilitation at parallel fiber-Purkinje cell synapses decreased in Duoxa-/- mice.

  2. DUOXA1 overexpression in muscle stem cells induces apoptosis and inhibits differentiation through DUOX1 and ASK1.

  3. DUOXA1 is a novel p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation.

  4. Nip1 has an important role in the guidance of neuronal differentiation through ROS generation and modulation of intermediate filaments

DUOXA1 Antigen Profile

Protein Summary

Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DUOXA1

  • dual oxidase maturation factor 2 (DUOXA2) antibody
  • dual oxidase maturation factor 1 (DUOXA1) antibody
  • dual oxidase maturation factor 1 (LOC100405759) antibody
  • dual oxidase maturation factor 1 (Duoxa1) antibody
  • BC019755 antibody
  • mol antibody
  • Nip antibody
  • Nip1 antibody
  • NUMBIP antibody
  • RGD1306601 antibody

Protein level used designations for DUOXA1

dual oxidase maturation factor 1 , Numb-interacting protein , dual oxidase activator 1 , dual oxidase maturation factor 1 alpha , dual oxidase maturation factor 1 beta , dual oxidase maturation factor 1 delta , dual oxidase maturation factor 1 gamma , homolog of Drosophila Numb-interacting protein , Numb-interacting protein 1

GENE ID SPECIES
427484 Gallus gallus
487536 Canis lupus familiaris
530151 Bos taurus
713058 Macaca mulatta
100405759 Callithrix jacchus
100446897 Pongo abelii
100596084 Nomascus leucogenys
90527 Homo sapiens
213696 Mus musculus
311374 Rattus norvegicus
100653516 Sus scrofa
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