anti-Dual Specificity Phosphatase 1 (DUSP1) Antibodies

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. Additionally we are shipping DUSP1 Kits (30) and DUSP1 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DUSP1 1843 P28562
DUSP1 19252 P28563
DUSP1 114856 Q64623
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Top anti-DUSP1 Antibodies at antibodies-online.com

Showing 10 out of 134 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN184638 (3.8µg/ml) staining of paraffin embedded Human Prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. ABIN184638 (0.3µg/ml) staining of HeLa lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Chicken Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of DUSP1 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of DUSP1 expression in HeLa (A) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Goat Un-conjugated IHC (p), IHC, ELISA, WB ABIN257653 staining (2µg/ml) of HeLa lysate (RIPA buffer, 35µg total protein per lane). Western Blot: MKP-1/DUSP1 Antibody [ABIN257653] - (0.3ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$485.88
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using MKP1 (Phospho-Ser359) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells, using MKP1 (Ab-359) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using MKP1 (Ab-359) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Goat Un-conjugated IHC (p), WB   0.1 mg Log in to see 8 to 11 Days
$462.00
Details
Bat Goat Un-conjugated ELISA, IHC, IHC (p), WB Human Prostate (formalin-fixed, paraffin-embedded) stained with DUSP1 antibody ABIN351458 at 3.75 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. Anti-DUSP1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 75 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Dog Rabbit Un-conjugated IHC, IHC (p), WB Human Placenta (formalin-fixed, paraffin-embedded) stained with DUSP1 antibody ABIN337195 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-DUSP1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Log in to see 11 to 14 Days
$727.83
Details
Human Rabbit Un-conjugated IF, WB The anti-DUSP1 Pab (ABIN392905) is used in Western blot to detect DUSP1 in 293 cell lysate. 400 μL Log in to see 10 to 11 Days
$335.50
Details

DUSP1 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-DUSP1 Antibodies

  1. Human Polyclonal DUSP1 Primary Antibody for IF (p), IHC (p) - ABIN735368 : Kato, Naiki-Ito, Naiki, Suzuki, Yamashita, Sato, Sagawa, Kato, Kuno, Takahashi: Connexin 32 dysfunction promotes ethanol-related hepatocarcinogenesis via activation of Dusp1-Erk axis. in Oncotarget 2016 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal DUSP1 Primary Antibody for IF (p) - ABIN894519 : Khadir, Tiss, Abubaker, Abufarha, Al-Khairi, Cherian, John, Kavalakatt, Warsame, Al-Madhoun, Al-Ghimlas, Elkum, Behbehani, Dermime, Dehbi: MAP kinase phosphatase DUSP1 is overexpressed in human obese and modulated by physical activity. in American journal of physiology. Endocrinology and metabolism 2014 (PubMed)

  3. Human Monoclonal DUSP1 Primary Antibody for IF, ELISA - ABIN515099 : Chao, Sun, Peng, Wu: Growth Hormone Releasing Peptide-2 Attenuation of Protein Kinase C-Induced Inflammation in Human Ovarian Granulosa Cells. in International journal of molecular sciences 2016 (PubMed)

  4. Human Polyclonal DUSP1 Primary Antibody for IHC (p), IHC - ABIN257653 : Alessi, Smythe, Keyse: The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts. in Oncogene 1993 (PubMed)

More Antibodies against DUSP1 Interaction Partners

Human Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. Downregulation of the expression of DUSP1 or protein phosphatase 1 led to a decline in the beta2adrenergic receptormediated dephosphorylation of ERK1/2.

  2. the expression of DUSP1 was lower in OA FLSs than in normal FLSs, and DUSP1 may inhibit the expression of OA-associated mediators, MMP-13 (show MMP13 Antibodies) and COX-2 (show COX2 Antibodies), by suppressing the activation of p38 MAPK (show MAPK14 Antibodies) and JNK (show MAPK8 Antibodies) pathways in OA FLSs.

  3. Curcumin suppressed CXCL5 (show CXCL5 Antibodies) expression by direct inhibition of IKKbeta (show IKBKB Antibodies) phosphorylation, and inhibition of p38 MAPK (show MAPK14 Antibodies) via induction of negative regulator MKP-1.

  4. MKP-1 is a redox-regulated master controller of monocyte function and macrophage phenotype. (Review)

  5. We propose a signaling cascade involving ARID1A (show ARID1A Antibodies), GADD45B (show GADD45B Antibodies) and DUSP1 as mediators of the romidepsin effects in GCC (show GUCY2C Antibodies) cells.

  6. this work indicates that suppression of JNK1 (show MAPK8 Antibodies)/2 activity by MKP-1 maintains PARP-1 (show PARP1 Antibodies) levels and suggests that MKP-1-mediated cisplatin resistance can be bypassed by PARP-1 (show PARP1 Antibodies) inhibition.

  7. Mean morning and evening DUSP1 mRNA levels showed significant increase during Ramadan compared to Shabaan, however, its diurnal rhythm was maintained. Morning IL-1alpha mRNA expression remained significantly higher than in the evening during Ramadan, but was markedly decreased compared to Shabaan.

  8. Methylation-mediated silencing of the DUSP-1 promoter does not appear to be associated with reduced expression, indicating the involvement of other factors in specific suppression of DUSP-1 in diabetes-associated cardiac hypertrophy.

  9. Increased MAP2K6 (show MAP2K6 Antibodies), MAP4K3 (show MAP4K3 Antibodies), and DUSP1 gene expressions in post-chemotherapy samples indicate a poor clinical outcome in osteosarcoma patients.

  10. The aim of this review is to shed light on the role of four different phosphatases (PTEN, PP2A (show PPP2R4 Antibodies), CDC25 (show RASGRF1 Antibodies) and DUSP1) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.

Mouse (Murine) Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. The results suggested that DUSP1 gene silencing promoted the release of proinflammatory cytokines through activation of the MAPK (show MAPK1 Antibodies) signaling pathway in mice with acute pancreatitis.

  2. The cardiac ischemia/reperfusion injury - induced DUSP1 deficiency promoted the activation of JNK (show MAPK8 Antibodies) which upregulated the expression of the mitochondrial fission factor (Mff (show MFF Antibodies)).

  3. Study demonstrates that MKP-1 serves as a master-regulator of macrophage phenotype and function and its dysregulation by metabolic stress may be a major contributor to atherogenesis and the progression of atherosclerotic plaques.

  4. FAM3D inhibits glucagon secretion via MKP1-dependent suppression of ERK1/2 signaling.

  5. these data show that MKP-1 is an important endogenous suppressor of innate immune responses involved in the regulation of blood-testis barrier barrier dynamic

  6. MKP-1 regulates IL-1beta (show IL1B Antibodies) production through stabilization of HIF-1alpha (show HIF1A Antibodies). The induction of HIF-1alpha (show HIF1A Antibodies) protein in MKP-1 deficiency is partly due to p38MAPK (show MAPK14 Antibodies) activation in response to LPS (show TLR4 Antibodies).

  7. this work identifies a previously unrecognized role for DUSP1 in regulating autophagy.

  8. c-FOS and DUSP1 expression levels determine the threshold of tyrosine kinase (show TYRO3 Antibodies) inhibitor (TKI) efficacy, such that growth-factor-induced expression of c-FOS and DUSP1 confers intrinsic resistance to TKI therapy in a wide-ranging set of leukemias.

  9. PTHrP counteracts the pro-apoptotic actions of reactive oxygen species by a mechanism dependent on MKP1-induced dephosphorylation.

  10. A2AR (show ADORA2A Antibodies) signaling regulates both basal and LPS (show TLR4 Antibodies)-induced DUSP1 levels in macrophages via activating the adenylate cyclase pathway.

Cow (Bovine) Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. MKP-1 is the specific phosphatase induced by AngII and involved in the negative feedback mechanism ensuring adequate ERK1/2-mediated aldosterone production in response to the hormone.

Pig (Porcine) Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. Agonist stimulation of vascular smooth muscle increases PKC (show FYN Antibodies) activity, which, in turn, increases MKP-1 activity and maintains MAPK1 (show MAPK1 Antibodies) activity at submaximal values.

DUSP1 Antigen Profile

Protein Summary

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.

Gene names and symbols associated with DUSP1

  • dual specificity phosphatase 1 (DUSP1) antibody
  • dual specificity phosphatase 1 (dusp1) antibody
  • dual specificity phosphatase 1 (Dusp1) antibody
  • 3CH134 antibody
  • cb269 antibody
  • CL100 antibody
  • DUSP1 antibody
  • erp antibody
  • HVH1 antibody
  • id:ibd2586 antibody
  • mkp-1 antibody
  • Mkp1 antibody
  • PTPN10 antibody
  • Ptpn16 antibody
  • sb:cb269 antibody
  • U19515 antibody
  • wu:fd19g02 antibody
  • wu:fe50g09 antibody
  • zgc:55920 antibody

Protein level used designations for DUSP1

dual specificity protein phosphatase 1 , dual specificity phosphatase 1 , mkp-1 , MAP kinase phosphatase 1 , dual specificity protein phosphatase hVH1 , mitogen-activated protein kinase phosphatase 1 , protein-tyrosine phosphatase CL100 , serine/threonine specific protein phosphatase , mitogen-activated protein kinase phosphatase-1 , protein tyrosine phosphatase, non-receptor type 16 , protein-tyrosine phosphatase 3CH134 , protein-tyrosine phosphatase ERP , 3CH134/CL100 PTPase , MAP kinase phosphatase-1 , mitogen-activated protein (MAP) kinase phosphatase-1 , oxidative stress-inducible protein tyrosine phosphatase , protein tyrosine phosphatase non-receptor type 16 , protein-tyrosine phosphatase non-receptor type 16 , MAPK phosphatase 1

GENE ID SPECIES
374192 Gallus gallus
471742 Pan troglodytes
100219518 Taeniopygia guttata
100340993 Oryctolagus cuniculus
406340 Danio rerio
1843 Homo sapiens
19252 Mus musculus
114856 Rattus norvegicus
489117 Canis lupus familiaris
539175 Bos taurus
100522469 Sus scrofa
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