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DUSP16 encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily.
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Human Polyclonal DUSP16 Primary Antibody for WB - ABIN2801915
Masuda, Shima, Watanabe, Kikuchi: MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein. in The Journal of biological chemistry 2001
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Human Polyclonal DUSP16 Primary Antibody for IHC (p), IHC - ABIN257675
Tanoue, Yamamoto, Maeda, Nishida: A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs. in The Journal of biological chemistry 2001
Human Polyclonal DUSP16 Primary Antibody for ICC, IF - ABIN443603
Bose, Janes: A high-throughput assay for phosphoprotein-specific phosphatase activity in cellular extracts. in Molecular & cellular proteomics : MCP 2013
The crystal structure of JNK1 (show MAPK8 Antibodies) bound to the catalytic domain of MKP7 at 2.4-A resolution, providing high-resolution structural insight into the FXF-docking interaction, is reported.
The DUSP16 ablation leads to a G1/S transition arrest, reduced incorporation of 5-bromodeoxyuridine, enhanced senescence-associated beta-galactosidase (show GLB1 Antibodies) activity, and formation of senescence-associated heterochromatic foci.
analysis of the interaction of the MAPK (show MAPK1 Antibodies) binding domain of DUSP16 with p38alpha (show MAPK14 Antibodies)
PPARdelta (show PPARD Antibodies)-mediated messenger RNA stabilization of mitogen-activated protein kinase (show MAPK1 Antibodies) phosphatase (MKP)-7 was responsible for the GW501516-mediated inhibition of JNK (show MAPK8 Antibodies) signaling.
Data indicate that the activities of phosphoprotein phosphatases MKP5 (show DUSP10 Antibodies) and MKP7 were determined in the system.
Data indicate that LRP6 (show LRP6 Antibodies), BCL2L14 (show BCL2L14 Antibodies), DUSP16, CREBL2 (show CREBL2 Antibodies), and CDKN1B (show CDKN1B Antibodies) were involed in centromeric (12p11.21-12p13.2) deletion in ETV6 (show ETV6 Antibodies)-RUNX1 (show RUNX1 Antibodies) B-cell precursor acute lymphoblastic leukemia (BCP (show OPN1SW Antibodies)-ALL).
MKP-7, a negative regulator of JNK (show MAPK8 Antibodies), regulates VCAM-1 (show VCAM1 Antibodies) expression in activated endothelial cells through IRF-1 (show IRF1 Antibodies) but not GATA6 (show GATA6 Antibodies).
DUSPs 10 and 16 are positive regulators of activation, apparently acting by modulating cross-talk between the p38 (show CRK Antibodies) and ERK (show EPHB2 Antibodies) pathways.
DUSP16 is a new epigenetically regulated determinant of JNK (show MAPK8 Antibodies) activation in BL.
MKP-7 down-regulates ERK (show EPHB2 Antibodies)-dependent gene expression by blocking nuclear accumulation of phospho-ERK (show EPHB2 Antibodies).
Ablation of Dusp16 enhanced axonal degeneration in response to trophic withdrawal, suggesting that it has a protective function. Moreover, axonal skin innervation was severely reduced while neuronal elimination was increased in the Dusp16 knockout. Mechanistically, Dusp16 negatively regulates the transcription factor p53 (show TP53 Antibodies) and antagonizes the expression of the pro-degenerative factor, Puma (show BBC3 Antibodies).
MAPK phosphatase 7 regulates T cell differentiation via inhibiting ERK (show EPHB2 Antibodies)-mediated IL-2 (show IL2 Antibodies) expression.
ADCY5 (show ADCY5 Antibodies) repression by miR-17 facilitated the translocation of EGFR (show EGFR Antibodies) and MKP7 from membrane into cytoplasmic and mitochondrial fractions.
Production of IL-10 (show IL10 Antibodies) and its inhibitory effect on IL-12 (show IL12A Antibodies) production were unaltered in Dusp16tp/tp macrophages.
the functional role of DUSP16 in Th1 (show HAND1 Antibodies)/Th2 balance.
the contrasting effects of acute and chronic stress on insulin (show INS Antibodies) sensitivity are driven by changes in subcellular distribution of MKP7 and activated JNK (show MAPK8 Antibodies)
DUSP16 is an important regulator of JNK (show MAPK8 Antibodies) activity and effector functions of CD4 (show CD4 Antibodies) and CD8 (show CD8A Antibodies) T cells.
JIP-1 (show MAPK8IP1 Antibodies) targets MKP-7 to dephosphorylate JNK (show MAPK8 Antibodies).
This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.
dual specificity phosphatase 16
, dual specificity protein phosphatase 16-like
, MAP kinase phosphatase 7
, MAPK phosphatase-7
, dual specificity protein phosphatase 16
, mitogen-activated protein kinase phosphatase 7
, MAP kinase phosphatase-7
, map kinase phosphatase-M