Dynein, Cytoplasmic 1, Intermediate Chain 1 Proteins (DYNC1I1)

Mouse (Murine) Dynein, Cytoplasmic 1, Intermediate Chain 1 (DYNC1I1) interaction partners

1. SQSTM1 is required for proper dynein motility and trafficking along microtubules.

2. results indicate that LIS1 is a previously unrecognized regulator of osteoclast formation, microtubule organization, and lysosomal secretion by virtue of its ability to modulate dynein function and Plekhm1

3. An all-atom model structure is obtained for dynein high-affinity form of microtubule (MT) binding domain bound to MT by an anisotropic network model, protein-protein docking, and molecular dynamics simulation

4. These results demonstrate the important role that dynein-controlled processes play in the correct development and function of the mammalian nervous system.

5. Study found six different Dync1i1 splicing pattern in mice.

Human Dynein, Cytoplasmic 1, Intermediate Chain 1 (DYNC1I1) interaction partners

1. Thus, these findings demonstrate a tumor-suppressive function of DYNC1I1, and uncover new mechanistic insights into SK2 regulation which may have implications in targeting this enzyme as a therapeutic strategy in glioblastoma

2. SQSTM1 is required for proper dynein motility and trafficking along microtubules.

3. Deletions of the exons with regulatory potential of DYNC1I1 are an example of the emerging role of exonic enhancer elements and their implications in congenital malformation syndromes

4. Genome sequencing of the deletion breakpoints showed that the DLX5 and DLX6 genes are disomic but the putative DYNC1I1 exon 15 and 17 enhancers are deleted.

5. NCAM and dynein have roles in tethering dynamic microtubules and maintaining synaptic density in cortical neurons

6. Both P-TEFb recruitment to the HIV long terminal repeat and enhanced HIV processivity were blocked by ERK inhibitor, but not by AKT and PI3K inhibitors.

7. the mRNA expression level of DYNC1I1 were significantly up-regulated in tumorous liver tissues compared with corresponding nontumorous counterparts.

8. NDE1 and NDEL1 act upstream of LIS1 in dynein recruitment, and/or activation, on the membrane.

9. identification of a novel 24-kDa protein that binds directly to dynein intermediate chain [PLAC-24]