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DYNLRB1 is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Additionally we are shipping DYNLRB1 Antibodies (5) and many more products for this protein.
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The presence of an N-terminal tag on dynein light-chain Roadblock/LC7 affects its interaction with a functional partner.
Human colorectal carcinoma cells display decreased tumor progression and invasion when a novel anti-cell motility target, DYNLRB1, is being silenced.
TGFbeta (show TGFB1 Proteins) regulates km23-1 interaction with the R1beta regulatory subunit of protein kinase A.
these findings demonstrate that km23-1 regulates RhoA (show RHOA Proteins) and motility-associated actin modulating proteins, suggesting that km23-1 may represent a novel target for anti-metastatic therapy.
km23-1 is required for TGFbeta1 (show TGFB1 Proteins) autoinduction through Smad2 (show SMAD2 Proteins)-independent Ras/ERK (show EPHB2 Proteins)/JNK (show MAPK8 Proteins) pathways
Silencing of km23, either through somatic genetic mutation or promoter hypermethylation, is rare in ovarian, breast, and colorectal cancers.
report the 2.1-A crystal structure of Dnlc2A using single anomalous diffraction
DYNLRB1 specifically interacts with all three Rab6 isoforms and co-localises at the Golgi.
Identification of dynein light chain road block-1 as a novel interaction partner with the human reduced folate carrier.
Findings indicate that km23-2 (DYNLRB2 (show DYNLRB2 Proteins)) is required for Smad3 (show SMAD3 Proteins)-dependent TGFbeta (show TGFB1 Proteins) signaling. Km23-2 has functions in TGFbeta (show TGFB1 Proteins) signaling that are distinct from those for km23-1 (DYNLRB1).
This gene is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression.
dynein light chain 2A, cytoplasmic
, dynein, cytoplasmic, light chain 2A
, dynein, cytoplasmic, light polypeptide 2A
, bithoraxoid-like protein
, dynein-associated protein Km23
, dynein-associated protein RKM23
, robl/LC7-like protein
, ROBL/LC7-like 1
, dynein light chain roadblock-type 1
, roadblock domain-containing protein 1