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E2F8 encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. Additionally we are shipping E2F8 Proteins (3) and many more products for this protein.
Showing 10 out of 43 products:
Human Monoclonal E2F8 Primary Antibody for ELISA, WB - ABIN566378
Li, Ran, Li, Gordon, Comstock, Siddiqui, Cleghorn, Chen, Kornacker, Liu, Pandit, Khanizadeh, Weinstein, Leone, de Bruin: Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. in Developmental cell 2008
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Human Polyclonal E2F8 Primary Antibody for ELISA, WB - ABIN450055
Lui, Baron: Evidence that Igf2 down-regulation in postnatal tissues and up-regulation in malignancies is driven by transcription factor E2f3. in Proceedings of the National Academy of Sciences of the United States of America 2013
Show all 2 Pubmed References
High E2F8 expression is associated with breast cancer.
E2F8 can shorten cisplatin induced G2/M arrest by promoting MASTL (show MASTL Antibodies) mediated mitotic progression in ER+ breast cancer cells, conferring drug resistance.
Study provides evidence that E2F8 functions as a proliferation-related oncogene (show RAB1A Antibodies) in papillary thyroid cancer progression. Moreover, miR (show MLXIP Antibodies)-144 appears to be a tumor suppressor through direct inhibition of E2F8.
Results showed that E2F8 is up-regulated in metastatic prostate cancer and associated with poor prognosis. These results indicate that E2F8 is a crucial transcription regulator controlling cell cycle and survival in prostate cancer cells.
E2F8-mediated transcriptional repression is a critical tumor suppressor mechanism during postnatal liver development
transcription factor E2F8 is involved in the polyploidization during mouse and human decidualization
E2F8 is overexpressed in Lung Cancer and is required for the growth of LC cells. E2F8 knockdown reduced the expression of UHRF1 (show UHRF1 Antibodies). These findings implicate E2F8 as a novel therapeutic target for LC treatment.
The results identify E2F8 as a repressor and E2F1 (show E2F1 Antibodies) as an activator of a transcriptional network controlling polyploidization in mammalian cells.
Analyses indicated that E2F8 could bind to regulatory elements of cyclin D1 (show CCND1 Antibodies), regulating its transcription and promoting accumulation of S-phase cells. Findings suggest that E2F8 contributes to the oncogenic potential of HCC (show FAM126A Antibodies)
The similarities between E2F-7 (show E2F7 Antibodies) and E2F-8 define a new subgroup of the E2F (show E2F1 Antibodies) family, and further imply that E2F-7 (show E2F7 Antibodies) and E2F-8 may act through overlapping mechanisms in mediating cell cycle control.
Rb and E2F8 collaborate to promote DNA replication.
The specificity of E2F8 in mediating Rb function in erythropoiesis suggests a critical and overlapping roles of Rb and E2f8 in maintaining normal erythropoiesis and in preventing hemolysis.
Overexpression of E2F8 significantly slows down the proliferation of primary mouse embryonic fibroblasts.
E2F8 may have an important role in repressing the expression of E2F (show E2F1 Antibodies)-target genes in the S-phase of the cell cycle.
Results identify E2F7 (show E2F7 Antibodies) and E2F8 as a unique repressive arm of the E2F (show E2F1 Antibodies) transcriptional network that is critical for embryonic development.
This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified.
E2F transcription factor 8
, E2F family member 8
, transcription factor E2F8
, transcription factor E2F8-like
, E2f family member 8