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Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA..
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Cow (Bovine) Polyclonal ELL2 Primary Antibody for WB - ABIN610716
Duckett, Nava, Gedrich, Clem, Van Dongen, Gilfillan, Shiels, Hardwick, Thompson: A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. in The EMBO journal 1996
Show all 3 Pubmed References
Human Polyclonal ELL2 Primary Antibody for IF (p), IHC (p) - ABIN1387852
Pascal, Masoodi, Liu, Qiu, Song, Wang, Zang, Yang, Wang, Rigatti, Chandran, Colli, Vencio, Lu, Zhang, Wang: Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia. in The Journal of endocrinology 2017
These results suggest that ELL2 and its pathway genes likely play an important role in the development and progression of prostate cancer.
Deletion of the Ell2 gene in mice results in loss of Ig secretion from plasma cells and reduced expression of a number of other genes involved in secretion and the unfol (show XBP1 Antibodies)ded pr (show ATF6 Antibodies)otein (show HSPA5 Antibodies) response l (show CCNB2 Antibodies)ike XBP1, Oc (show POU2AF1 Antibodies)aB (BOB1, (show POU2AF1 Antibodies) Pou2af1), cyclin B2 and Ig light chain
The splicing factor hnRNPLL and the transcription elongation factor ELL2 modulate the ratio of secred versus membrane-encoding Ighg2b transcripts at the expense of the secreted isoform.
ELL2 enhanced both polyadenylation and exon skipping with the gene encoding the immunoglobulin heavy-chain complex (Igh) and reporter constructs
Results provide the first evidence that ELL2 is a direct target of miR (show MLXIP Antibodies)-299 and increased ELL2 expression and down-regulation of miR (show MLXIP Antibodies)-299 are associated with GBM progression and poor prognosis in patients.
Selective expression of the transcription elongation factor (show TSFM Antibodies) ELL3 (show ELL3 Antibodies) in B cells prior to ELL2 drives proliferation and survival
multiple myeloma risk allele harbours a Thr298Ala missense variant in an ELL2 domain required for transcription elongation
Tax (show CNTN2 Antibodies) transactivates the ELL2 promoter in HTLV-1-infected T-cells.
Loss of ELL2 in B cells results in decreased Igh secretory mRNA and decreased expression of Ig light chain plus genes involved in the unfolded protein response like XBP1 (show XBP1 Antibodies), ATF6 (show ATF6 Antibodies), BiP (show GDF10 Antibodies), cyclin B2 (show CCNB2 Antibodies), OcaB (BOB1 (show POU2AF1 Antibodies), Pou2af1 (show POU2AF1 Antibodies)).
Prostratin and HMBA, two well-studied activators of HIV transcription and latency, enhance ELL2 accumulation and SECs formation largely through decreasing Siah1 (show SIAH1 Antibodies) expression and ELL2 polyubiquitination.
ELL2 addition regulates mRNA processing by enhancing poly(A) site choice and exon splice-site skipping
Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.
RNA polymerase II elongation factor ELL2
, elongation factor, RNA polymerase II, 2
, elongation factor, RNA polymerase 2, 2
, RNA polymerase II elongation factor ELL2-like
, ELL-related RNA polymerase II, elongation factor
, eleven-nineteen lysine-rich leukemia gene 2