ELL2 antibody

Catalog No. ABIN7113781

This Rabbit Polyclonal antibody specifically detects ELL2 in WB, ELISA and IP. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ELL2 antibody (ABIN7113781)

Target: ELL2 (Elongation Factor, RNA Polymerase II, 2 (ELL2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ELL2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Product Details anti-ELL2 Antibody

Purpose: ELL2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: elongation factor, RNA polymerase II, 2

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for ELL2

Target: ELL2 (Elongation Factor, RNA Polymerase II, 2 (ELL2))

Alternative Name: ELL2

Background:

Synonyms: RNA polymerase II elongation factor ELL2|ELL2

Background: Elongation factor component of the super elongation complex(SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex(LEC), a complex required to regulate small nuclear RNA(snRNA) gene transcription by RNA polymerase II and III(PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain(IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.

Molecular Weight: 72 kDa

Gene ID: 22936

UniProt: O00472