anti-Eukaryotic Translation Elongation Factor 1 alpha 2 (EEF1A2) Antibodies

Human Eukaryotic Translation Elongation Factor 1 alpha 2 (EEF1A2) interaction partners

1. The overexpression of EEF1A2 is a frequent event in localized prostate cancer and is associated with histopathology features and a shorter biochemical recurrence-free survival. Due to its independence from serum PSA levels, EEF1A2 could serve as valuable biomarker in risk-stratification of localized prostate cancer

2. We report a pair of siblings carrying a homozygous missense mutation p.P333L in EEF1A2 who exhibited global developmental delay, failure to thrive, dilated cardiomyopathy and epilepsy, ultimately leading to death in early childhood. EEF1A2 appears to be critical for normal heart function in humans, and its deficiency results in clinical abnormalities in neurologic function as well as in skeletal and cardiac muscle defects

3. eEF1A2 is highly expressed in hepatocellular carcinoma. Its silencing significantly decreases HCC tumorigenesis, likely by inhibiting PI3K/Akt/NF-kappaB signaling.

4. Differential gene expression analysis demonstrated significant upregulation of PDZK1IP1, EEF1A2 and RPL41 (ENSG00000279483) genes in the intrahepatic cholangiocarcinoma samples when compared with the matched paratumor samples.

5. In both cases, a de novo recurrent heterozygous mutation in EEF1A2 [c.364G>A (p.E122K)] was identified by whole-exome sequencing. CONCLUSION: This report provides clinical data on epileptic encephalopathy in patients with EEF1A2 mutation. Continuous high-voltage delta activity seen over both parietal areas may be a unique manifestation of EEF1A2 mutation.

6. Our results provide novel information on the intracellular distribution and interaction of eEF1A isoforms.

7. By directly targeting eEF1A2.

8. Both eEF1A1 and eEF1A2 colocalise with all eEF1B subunits, in such close proximity that they are highly likely to be in a complex.

9. De novo EEF1A2 mutations in patients with characteristic facial features, intellectual disability, autistic behaviors and epilepsy.

10. Finally, a strong association between the expression of EEF1A2, phosphorylated AKT and MDM4 was observed in human HCC samples. Strong activation of the EEF1A2/PI3K/AKT/mTOR/MDM4 signaling pathway was observed in HCC patients

11. Overexpression of eEF1A2 was correlated with worse outcomes in gastric cancer patients, suggesting its critical roles in the carcinogenesis of gastric cancer.

12. miR-663 and miR-744 mediate inhibition of the proto-oncogene eEF1A2 expression that results in retardation of the MCF7 cancer cells proliferation. We also observed upregulation of miR-663 and miR-744 with corresponding downregulation of eEF1A2 in resveratrol-treated MCF7 cells, suggesting that resveratrol may influence eEF1A2 expression through a miRNA-dependent pathway.

13. Our data suggests that eEF1A2 plays an important role in prostate cancer development, especially in inhibiting apoptosis.

14. The activation level of the EEF1A2/PI3K/AKT/mTOR/MDM4 axis significantly influences the survival probability of hepatocellular carcinoma patients

15. There was no significant correlation between eEF1A2 protein and mRNA expression levels. Negative immunostaining of eEF1A2 predicted for poor prognosis of NSCLC.

16. results provide evidence of eEF1A2 as a potential therapeutic target in the treatment of aggressive pancreatic cancer

17. Data conclude that the interaction of p16(INK4a) with eEF1A2, and subsequent downregulation of the expression and function of eEF1A2 is a novel mechanism explaining the anti-proliferative effects of p16(INK4a).

18. a role for a RACK1/JNK/eEF1A2 complex in the quality control of newly synthesized polypeptides in response to stress

19. Pilot evaluation in archive prostate tissues showed the presence of EEF1A2 mRNA in near all neoplastic and perineoplastic but not in normal samples or in benign adenoma; in contrast, EEF1A1 mRNA was everywhere detectable

20. The eEF1A2 likely plays an important role in mammary neoplasia and acinar development.

Mouse (Murine) Eukaryotic Translation Elongation Factor 1 alpha 2 (EEF1A2) interaction partners

1. The presence of G70S protein was not sufficient to protect mice from neurodegeneration in G70S/- eEF1A2 mice, showing that the mutant protein is essentially non-functional.

2. This provides the first in vivo confirmation that eEF1A2 plays an important role in translation.

3. Heterozygous mutant mice showed no deficit in neuromuscular function or signs of spinal cord pathology, in spite of the low levels of eEF1A2

4. In-depth analysis using site-directed mutagenesis revealed that PKCbetaI could phosphorylate Ser(3) of the eEF1A2 isoform and that the association between eEF1A2 and PKCbetaI was dependent on the phosphorylation status of eEF1A2

5. EEF1A2 may play contribute to the induction or progression of some plasmacytomas and a small percentage of multiple myeloma.

6. these results suggest an important role for eEF1A2 in driving cap-independent translation of utrophin A in skeletal muscle.

7. expression of eEF1A-2/S1 protein is activated upon myogenic differentiation

8. This is a putative oncogene in ovarian cancer.

9. Data suggest that spontaneous failure of eEF1A2 expression in the wasted mutant first triggers gliosis in spinal cord and retraction of motor nerve terminals in muscle, and then motor neuron pathology and death.

10. eEF1A-2 interacts with Prdx-I to functionally provide cells with extraordinary resistance to oxidative stress-induced cell death[eEF1A-2 and Prdx-I]

11. The above findings suggest that an increase in free-form eEF1A under alkaline conditions plays a critical role in alkalinization-induced cell growth.

Rabbit Eukaryotic Translation Elongation Factor 1 alpha 2 (EEF1A2) interaction partners

1. the interaction of eEF1A with two known partners - calmodulin and actin

2. eEF1A2 crystals obtained using ammonium sulfate as precipitant diffracted to 2.5 A resolution and belonged to space group P6(1)22 or P6(3)22 (unit-cell parameters a = b = 135.4, c = 304.6 A).