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The results indicate that FCRL3 gene polymorphisms are associated with the development and progression of IgA nephropathy (IgAN) in a Chinese Han population, and the rs11264794-A allele showed a protective role for IgAN due to reduced specific binding between miR-183-5p.1 and FCRL3 3'-untranslated region.
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This study identified novel single nucleotide polymorphism in FCRL3 and FCRL5 significantly associated with the risk for asthma with comorbid allergic rhinitis in the Chinese population
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FCRL3 -169C allele may increase the risk of developing tendinopathy.
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no association between the FCRL-3 rs7528684 SNP with susceptibility to allergic asthma in Iranian North-Western Azeri population.
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-169CC genotype associated with a beneficial functional effect on residual insulin secretion and HbA1c level dynamics in type 1 diabetes
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Pooled genome wide association study identified a genetic variant upstream of FCRL3 as a susceptibility locus for Graves' disease in addition to those identified in the Major Histo-compatibility Complex.
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The expression of Sezary signature genes: FCRL3, Tox, and miR-214, was significantly higher in samples from Sezary syndrome patients with CD164 expressing CD4(+) T cells.
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This study aims to investigate the association between common polymorphisms of FCRL3 gene and multiple sclerosis risk in a Chinese Han population.
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Observed no association between the MHC2TA or FCRL3 SNPs and rheumatoid arthritis in Mexican patients.
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genetic polymorphism is associated with rheumatoid arthritis in Chinese Han population
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Genetic polymorphisms in FCRL3 are genetic risk factors for neuromyelitis optica in the Chinese population.
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FCRL3_3, FCRL3_5 and FCRL3_6 polymorphisms could increase susceptibility to Graves' disease only in Asians, rather than in Caucasians.
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CTLA4 and FCRL3 genes overexpression may play an important role in children suffering from autoimmune thyroiditis.
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FCRL3 genetic polymorphisms were associated with an increased risk of endometriosis-related infertility, regardless of symptoms.
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4 Single Nucleotide Polymorphisms (rs7528684, rs945635, rs3761959, and rs2282284) could significantly elevate the risk of Neuromyelitis Optica in Chinese Han population.
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study found a significant association between the SNPs in FCRL3 gene and allergic rhinitis (AR) in Chinese Han patients; results suggest these gene polymorphisms might be the autoimmunity risk for AR
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Association between FCRL3 polymorphisms and increased risk of sudden sensorineural hearing loss in a Chinese Han population.
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the TIGIT/FCRL3 combination allows reliable identification of Helios(+) Treg cells even in highly activated conditions in vitro as well as in PBMCs of autoimmune patients.
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CONCLUSIONS: Our study demonstrated that the FCRL3 -169T>C polymorphism is not a risk factor of systemic lupus erythematosus in the Polish population, but this polymorphism may contribute to autoantibody production in this disease.
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the FCRL3 polymorphisms are associated with not only autoimmune diseases including RA, GD, T1D, and other disease under different genetic models, but also different ethnic subgroups.