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Fetuin B serum concentrations are not significantly different between patients with lipodystrophy (LD) and non-LD controls.
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Patients with type 2 diabetes have significantly higher concentrations of plasma fetuin-B compared with normal glucose tolerance subjects and plasma fetuin-B is strongly associated with glucose and lipid metabolism, chronic inflammation and first-phase glucose-stimulated insulin secretion and insulin resistance.
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Fetuin-A can alter insulin signaling and that fetuin-B may regulate glucose homeostasis via so far unknown effects, possibly on glucose effectiveness.
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Carrying the minor G allele for FETUB rs4686434 was significantly associated with decreased intrahepatic triglyceride content and may affect hepatic triglyceride accumulation in individuals at high risk of non-alcoholic fatty liver disease.
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High Serum fetuin-B expression is associated with insulin resistance.
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fetuin B may serve as a potential biomarker for coronary artery disease
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Increased serum fetuin-B level was significantly associated with higher risk of insulin resistance. Common genetic variants of FETUB SNPs (rs4686434, rs6785067, and rs3733159) were significantly associated with serum fetuin-B concentrations but were not associated with insulin resistance.
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serum level of fetuin B in the control subjects was lower than it in nonalcoholic fatty liver disease patients. fetuin B correlated with diastolic blood pressure, serum alanine transaminase and triglycerides, among the controls. It suggested a potential association between serum fetuin B and the presence of NAFLD.
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Further studies need to elucidate factors contributing to fetuin B regulation in humans, as well as the pathophysiological significance of fetuin B upregulation in gestational diabetes
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Data indicate that fetuin-B was one of the highly expressed serum proteins in acute myocardial infarction.
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Reduced expression of fetuin-b led to a significant increase in the expression of lipogenic genes, thereby resulting in higher lipid levels.
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serum fetuin has a role in processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 in cultured human vascular smooth muscle cells
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results support the hypothesis that fetuin-A serum levels are associated with bone cell activity
