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FLNC encodes one of three related filamin genes, specifically gamma filamin. Additionally we are shipping FLNC Kits (33) and FLNC Proteins (5) and many more products for this protein.
Showing 10 out of 42 products:
Human Polyclonal FLNC Primary Antibody for ICC, IF - ABIN4312164
Valdés-Mas, Gutiérrez-Fernández, Gómez, Coto, Astudillo, Puente, Reguero, Álvarez, Morís, León, Martín, Puente, López-Otín: Mutations in filamin C cause a new form of familial hypertrophic cardiomyopathy. in Nature communications 2014
Show all 3 Pubmed References
Human Polyclonal FLNC Primary Antibody for ELISA, WB - ABIN560923
Sakane, Alamir Mahmoud Abdallah, Nakano, Honda, Kitamura, Imoto, Matsushita, Sasaki: Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins. in Genes to cells : devoted to molecular & cellular mechanisms 2013
Show all 2 Pubmed References
Cow (Bovine) Polyclonal FLNC Primary Antibody for WB - ABIN2789843
Begay, Tharp, Martin, Graw, Sinagra, Miani, Sweet, Slavov, Stafford, Zeller, Alnefaie, Rowland, Brun, Jones, Gowan, Mestroni, Garrity, Taylor: FLNC Gene Splice Mutations Cause Dilated Cardiomyopathy. in JACC. Basic to translational science 2016
HSPB7 (show HSPB7 Antibodies) is essential for maintaining muscle integrity, which is achieved through its interaction with FLNC
The data of this study presented here provide further support that FLNC, a muscle-specific protein (show TXLNB Antibodies), could be a potential novel player in FTD (show FTL Antibodies) pathogenesis.
Aciculin (show PGM5 Antibodies) interacts with filamin C and Xin (show XIRP1 Antibodies) and is essential for myofibril assembly.
KY, IGFN1 and FLNC are part of a Z-band associated protein complex likely to provide structural support to the skeletal muscle sarcomere.
filamin C may function in signal transduction or cellular migration of the myogenic progenitor cell population
These data provide the first evidence that FLNc has a crucial role in muscle development and maintenance of muscle structural integrity and suggest the presence of a TRIO (show TRIO Antibodies)-FLNc-dependent pathway in maintaining proper myotube structure.
MuRF3 (show TRIM54 Antibodies) has an essential role in maintaining cardiac integrity and function after acute myocardial infarction and turnover of FHL2 (show FHL2 Antibodies) and gamma-filamin contributes to this cardioprotective function of MuRF3 (show TRIM54 Antibodies)
Cbl (show CBL Antibodies)-associated protein provides another link between the myofibril cytoskeleton and the plasma membrane of muscle cells, and it may play a dynamic role in the regulation and maintenance of muscle structural integrity
a novel variant in FLNC was identified as pathogenic variant for familial Restrictive cardiomyopathy.
The study confirms that truncating variants on myofibrillar myopathies- causing genes are frequently associated with dilated cardiomyopathies and also suggest that FLNC mutations could be considered as a common cause of dilated cardiomyopathy.
Study found a novel splice-site mutation in FLNC gene (c.2389+1G>A) which co-segregated with all symptomatic individuals in the family with dilated cardiomyopathy (DCM). These results strongly suggest that the involvement of FLNC gene, due to haploinsufficiency, should be considered in familial cases with DCM, especially if accompanied with arrhythmia and increased incidence of sudden cardiac death.
Filamin C promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rac1/cdc42 (show CDC42 Antibodies) activites in esophageal squamous cell carcinoma.
Data show that the filamin C (FLNC) protein was significantly overexpressed with the development of hepatocellular carcinoma (HCC (show FAM126A Antibodies)), which might play an important role in HCC (show FAM126A Antibodies) invasion and metastasis.
Missense variant in FLNC gene is associated with reading disability.
suggest that the combination of the OBSCN (show OBSCN Antibodies) p.Arg4444Trp variant and of the FLNC c.5161delG mutation, can cooperatively affect myofibril stability and increase the penetrance of muscular dystrophy in the French family
This study therefore identifies both BAG3 (show BAG3 Antibodies) reduction and autophagy promotion as potential therapies for FLNC(W2710X) myofibrillar myopathy, and identifies protein insufficiency due to sequestration, compounded by impaired autophagy, as the cause.
Biallelic variants in FLNC can cause congenital dilated cardiomyopathy.
Truncating mutations in FLNC caused an overlapping phenotype of dilated and left-dominant arrhythmogenic cardiomyopathies complicated by frequent premature sudden death
This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene.
filamin C, gamma (actin binding protein 280)
, gamma filamin
, filamin C, gamma
, ABP-280-like protein
, actin binding protein 280
, actin-binding protein 280
, actin-binding-like protein
, filamin, gamma
, ABP-L, gamma filamin
, filamin 2
, 260kDa actin-binding protein
, cgABP260 actin-binding domain