FLNC antibody (N-Term)

Catalog No. ABIN2789843

Product Details anti-FLNC Antibody

Target: FLNC (Filamin C, gamma (FLNC))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FLNC antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VGKSADFVVE AIGTEVGTLG FSIEGPSQAK IECDDKGDGS CDVRYWPTEP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against FLNC. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human FLNC

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 2692 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-FLNC antibody (ABIN2789843)

Begay, Tharp, Martin, Graw, Sinagra, Miani, Sweet, Slavov, Stafford, Zeller, Alnefaie, Rowland, Brun, Jones, Gowan, Mestroni, Garrity, Taylor: "FLNC Gene Splice Mutations Cause Dilated Cardiomyopathy." in: JACC. Basic to translational science, Vol. 1, Issue 5, pp. 344-359, (2016) (PubMed).

Target Details for FLNC

Target: FLNC (Filamin C, gamma (FLNC))

Alternative Name: FLNC (FLNC Products)

Synonyms: 1110055E19Rik antibody, ABP-280 antibody, ABPL antibody, Fln2 antibody, ABP280A antibody, ABPA antibody, FLN2 antibody, MFM5 antibody, MPD4 antibody, filamin C antibody, filamin C L homeolog antibody, filamin C, gamma antibody, FLNC antibody, flnc.L antibody, flnc antibody, Flnc antibody

Background: This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: ABP-280, ABP280A, ABPA, ABPL, FLJ10186, FLN2
Protein Interaction Partner: RAPGEF2, TRIM63, TRIM55, XIRP1, XIRP2, SYNPO2, UBC, KCMF1, CTTNBP2NL, ANKRD28, ARFGEF2, NCAPD2, TXNL1, PSMD13, PSMD12, PSMD3, NUP88, IKBKB, FLNB, AP3S1, NPM1, IGSF8, FN1, IQCB1, TP63, VCAM1, RPS6KA2, DYNLRB1, NUP133, SAP30BP, SF3A3, SRSF9, ENO1, EEF1G, EE
Protein Size: 2692

Molecular Weight: 296 kDa

Gene ID: 2318

NCBI Accession: NM_001127487, NP_001120959

UniProt: Q14315