Fragile Histidine Triad (FHIT) ELISA Kits

FHIT, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. Additionally we are shipping FHIT Antibodies (150) and FHIT Proteins (25) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
FHIT 2272 P49789
FHIT 60398 Q9JIX3
FHIT 14198 O89106
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Top FHIT ELISA Kits at

Showing 4 out of 10 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 7.8 pg/mL 31.2-2000 pg/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
Mouse < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Log in to see 11 to 18 Days
Rat < 46.9 pg/mL 78 pg/mL - 5000 pg/mL   96 Tests Log in to see 11 to 18 Days
  96 Tests Log in to see 15 to 18 Days

More ELISA Kits for FHIT Interaction Partners

Human Fragile Histidine Triad (FHIT) interaction partners

  1. Fhit expression impacts the translation of a number of cancer associated genes.

  2. overexpression of Fhit, a tumor suppressor protein, induces autophagy in NSCLC cells. Further, we found that this autophagy is mediated by 14-3-3tau and plays a cytoprotective role against the antitumor effect of Fhit both in vitro and in vivo.

  3. Review/Meta-analysis: significant difference in FHIT gene promoter methylation status in non-small cell lung carcinoma patients was found in Asians but not in Caucasian population.

  4. these results show that squamous cell carcinomas of the vulva presents a characteristic molecular pattern with FHIT being downregulated whereas HMGA2 is upregulated

  5. It has been proposed that Fhit and Wwox (show WWOX ELISA Kits) loss work synergistically in cancer progression and that DNA damage caused by Fhit could be targeted early in cancer initiation for prevention, while DNA damage caused by Wwox (show WWOX ELISA Kits) loss could be targeted later in cancer progression, particularly in cancers that develop resistance to genotoxic therapies. (Review)

  6. Two variants were identified for maximal voluntary ventilation and located in the genes of LOC102724340 (rs41434646) and FHIT (rs9833533). FHIT represses transcriptional activity of beta-catenin (show CTNNB1 ELISA Kits), a critical protein for growth of skeletal muscle, and thus might have influenced the level of maximal voluntary ventilation.

  7. This study demonstrates that Fhit down-regulation is an early event in both multistep carcinogenic processes leading to pancreatic ductal adenocarcinoma

  8. The results have implications for the mechanism by which Fhit regulates TK1 (show TK1 ELISA Kits) mRNA, and more broadly, for its modulation of multiple functions as tumor suppressor/genome caretaker.

  9. RARb and FHIT promoter methylation may be associated with the carcinogenesis of cervical cancer. FHIT promoter methylation may play a crucial role in cervical cancer progression. Additional studies with large sample sizes are essential to confirm our findings.

  10. The peptide was located within the 'disordered' region, which is invisible in the known crystal structures of Fhit.

Cow (Bovine) Fragile Histidine Triad (FHIT) interaction partners

  1. the same mRNA isoforms of FHIT were detected in bladder tumors and in healthy tissues, including a novel isoform that was found in this study, suggesting that epigenetic modifications and altered expression profiles are not a hallmark of vesical tumors

Mouse (Murine) Fragile Histidine Triad (FHIT) interaction partners

  1. Fhit loss and subsequent thymidine kinase 1 (show TK1 ELISA Kits) inactivation, combined with selective pressures, leads to neoplasia-associated alterations in genes and gene expression patterns in vitro and in vivo

  2. Fhit-deficiency mutation signature also resembles a C>T and T>C mutation signature reported for human papillary kidney cancers and a similar signature recently reported for esophageal and bladder cancers, cancers that are frequently Fhit deficient.

  3. Fhit deficiency-induced global genome instability promotes mutation and clonal expansion

  4. Fhit delocalizes annexin A4 (show ANXA4 ELISA Kits) from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.

  5. FHIT gene is a "caretaker gene" necessary for maintenance of genome stability.

  6. Loss of Fhit expression contributes to cell transformation.

  7. Defects in Fhit expression may promote MHC-I down-regulation in cancer cells and allow escape from immunosurveillance.

  8. Human and mouse orthologous genes, FHIT and Fhit, are more highly conserved through evolution than PTPRG/Ptprg (show PTPRG ELISA Kits) and yet contain more sequence elements that are exquisitely sensitive to genomic rearrangements

  9. Association of Fhit gene inactivation with increased survival after DNA damage, related to over-active checkpoints regulated by ATR/CHK1 pathway. Potential effects of Fhit-dependent DNA damage response on tumor progression.

  10. Fhit has a role in bladder cancer development

FHIT Antigen Profile

Antigen Summary

This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with FHIT

  • fragile histidine triad (FHIT) antibody
  • fragile histidine triad (Fhit) antibody
  • fragile histidine triad gene (fhit) antibody
  • fragile histidine triad gene (Fhit) antibody
  • fragile histidine triad (fhit) antibody
  • fragile histidine triad protein (PY07476) antibody
  • fragile histidine triad L homeolog (fhit.L) antibody
  • AP3Aase antibody
  • AW045638 antibody
  • FHIT antibody
  • FRA3B antibody
  • Fra14A2 antibody
  • LOC100223655 antibody
  • zgc:73176 antibody

Protein level used designations for FHIT

AP3A hydrolase , bis(5'-adenosyl)-triphosphatase , diadenosine 5',5'''-P1,P3-triphosphate hydrolase , dinucleosidetriphosphatase , tumor suppressor protein , AP3Aase , fragile histidine triad protein , fragile histidine triad gene , diadenosine triphosphate hydrolase , fragile histidine triad

2272 Homo sapiens
100215999 Canis lupus familiaris
692183 Bos taurus
60398 Rattus norvegicus
100307043 Ovis aries
393713 Danio rerio
14198 Mus musculus
448702 Xenopus (Silurana) tropicalis
100223655 Taeniopygia guttata
3800584 Plasmodium yoelii yoelii 17XNL
416071 Gallus gallus
495983 Xenopus laevis
700974 Macaca mulatta
747260 Pan troglodytes
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