anti-GTP Cyclohydrolase 1 (GCH1) Antibodies

GCH1 encodes a member of the GTP cyclohydrolase family. Additionally we are shipping GTP Cyclohydrolase 1 Proteins (12) and GTP Cyclohydrolase 1 Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GCH1 2643 P30793
GCH1 14528 Q05915
GCH1 29244 P22288
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Top anti-GTP Cyclohydrolase 1 Antibodies at

Showing 10 out of 88 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-GCH1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: COLO205 cell lysate 100 μL 2 to 3 Days
Human Mouse Un-conjugated IHC (p), IP, ELISA, WB Immunoperoxidase of monoclonal antibody to GCH1 on formalin-fixed paraffin-embedded human lymph node. [antibody concentration 3 ug/ml] GCH1 monoclonal antibody (M01), clone 4A12 Western Blot analysis of GCH1 expression in IMR-32 . 100 μg 11 to 12 Days
Human Goat Un-conjugated ELISA, IHC, WB Antibody (0.5µg/ml) staining of Human Tonsil lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: GCH1 Sample Tissue: Human Fetal Heart Antibody Dilution: 1ug/ml 100 μL 2 to 3 Days
Human Mouse Un-conjugated IP, ELISA, WB 100 μg 11 to 14 Days
Bat Goat Un-conjugated ELISA, WB 100 μg 11 to 14 Days
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
Human Rabbit Un-conjugated ELISA, WB Western blot analysis GCH1 using K562 whole cell lysates 100 μL 11 to 12 Days
Human Goat Un-conjugated ELISA, WB 0.1 mg 2 to 3 Days
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis in ZR-75-1 cell line lysates (35ug/lane). GCH1 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL 2 to 3 Days

Top referenced anti-GTP Cyclohydrolase 1 Antibodies

  1. Human Monoclonal GCH1 Primary Antibody for IHC (p), IP - ABIN561018 : Widder, Chen, Li, Dikalov, Thöny, Hatakeyama, Harrison: Regulation of tetrahydrobiopterin biosynthesis by shear stress. in Circulation research 2007 (PubMed)
    Show all 11 Pubmed References

  2. Human Polyclonal GCH1 Primary Antibody for ELISA, WB - ABIN451682 : Tegeder, Costigan, Griffin, Abele, Belfer, Schmidt, Ehnert, Nejim, Marian, Scholz, Wu, Allchorne, Diatchenko, Binshtok, Goldman, Adolph, Sama, Atlas, Carlezon, Parsegian, Lötsch, Fillingim, Maixner et al.: GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. ... in Nature medicine 2006 (PubMed)

More Antibodies against GTP Cyclohydrolase 1 Interaction Partners

Human GTP Cyclohydrolase 1 (GCH1) interaction partners

  1. High GCH1 expression is associated with glioblastoma.

  2. The results of this study showed that no effect on pain perception was observed for this combined GTP-cyclohydrolase-1 haplotype.

  3. Dopa-responsive dystonia proband was found to be a compound heterozygote for GCH1 variants. Pedigree analysis demonstrates reduced penetrance of GCH1 mutations.

  4. In a Chinese population, GCH1 rare variants were associated with a risk factor for Parkinson's disease.

  5. Her 2 uncles and probably her 2 grandaunts also have limbs tremor. Genetic analysis by using PCR-direct sequencing revealed a novel point mutation (c.263G>T: p. Arg88Leu) in GCH1

  6. The study indicates potential contribution of GCH1 polymorphisms to the variability of pain in African Americans with sickle cell disease.

  7. the pivotal role of GCH1 overexpression in post-infarction cardiac remodeling is attributable to preservation of neuronal nitric oxide synthase and sarcoplasmic reticulum Ca(2+) handling proteins, and identify a new therapeutic target for cardiac remodeling after infarction.

  8. Study identified 15 patients with GCH1 mutations (15 patients from seven families and five sporadic cases). The patients presented two distinctive phenotypes of juvenile or young-onset dopa-responsive dystonia and Parkinson's disease, which clinically and radiologically shared characteristic features. GCH1 mutations induce the distinctive symptoms among young or middle age at onset.

  9. It is a genetic risk for Parkinson's disease.

  10. One novel mutation of c.679A>G (p.T227A) in GCH1 and 3 known mutations of c.457C>T (p.R153X), c.739G>A (p.G247S), and c.698G>A (p.R227H) in tyrosine hydroxylase (TH) have been found and predicted to be damaging or deleterious.

  11. Our data expand the genotypic spectrum of GCH1 and confirm the broad phenotypic spectrum of GTP cyclohydrolase 1-deficient DOPA-responsive dystonia in the Serbian population

  12. Our results suggest that rs329648 is associated with risk of developing PD in the Han Chinese population. Our findings should be verified in further studies, and they highlight the need for functional studies of MIR4697.

  13. Association analysis indicated that the Tibetan version of GCH1 was significantly associated with multiple physiological traits in Tibetans, including blood nitric oxide concentration, blood oxygen saturation, and hemoglobin concentration.

  14. This study indicates that mutations in GCH1 are rare in late-onset Parkinson disease.

  15. This study shown GCH1 genetic variants for Parkinson's disease are associated with the risk of incident Parkinson's disease in the general population and with impairment in daily functioning in individuals without clinical parkinsonism.

  16. GCH1 variants affect early PD risk through altered dopamine uptake, and aging alters how genetic factors contribute to disease development.

  17. c.550C>T mutation is associated with dopa-responsive dystonia.

  18. This study demonstrated that whole-exome sequencing show reveled GCH1 mutation with early-onset generalized dystonia.

  19. Deletion of GCH1 likely contributes to dopa-responsive dystonia.

  20. High GCH1 expression is associated with esophageal squamous cell carcinoma.

Mouse (Murine) GTP Cyclohydrolase 1 (GCH1) interaction partners

  1. The GTPCH p.Leu117Arg missense mutation is deleterious and could cause tetrahydrobiopterin, phenylalanine and neurotransmitter metabolic disturbances and infancy-onset motor dysfunctions recessively. This is the first GTPCH deficiency mouse model which could be live-born and exhibits significant motor impairments.

  2. Suggest key roles for endothelial cell and leucocyte Gch1 and BH4 in the progression of atherosclerosis.

  3. GCH1-induced cardioprotection against DCM mainly involves the tetrahydrobiopterin/nNOS/sarcoplasmic reticulum Ca2+ handling proteins signaling pathway and depression of p38 Mitogen-Activated Protein Kinases in Diabetes Mellitus, Type 1.

  4. Cardiomyocyte-specific overexpression of GTP cyclohydrolase I (mGCH) increases BH4 several-fold in the heart.

  5. gene expression analysis after iNOS induction identified 78 genes that were altered between wild-type and Gch1(fl/fl)Tie2cre macrophages

  6. Data indicate that global deficiency in GTP cyclohydrolase I (Gch1) is embryonically lethal between E11.5 and E13.5.

  7. There is a cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.

  8. Inhibition of GCH1 prevented the Escherichia coli K1 induced expression of CD64 in macrophages in vitro and the development of bacteremia in a newborn mouse model of meningitis.

  9. The GTPCH I/Tetreahydrobiopterin pathway is critical to preserve endothelial progenitor cells quantity, function, and regenerative capacity during wound healing in type 1 diabetic mice.

  10. maintenance of endothelial GTPCH I expression and the resulting improvement in BH4 biosynthesis ameliorate diabetic nephropathy

  11. The involvement of the GCH1 gene in pain models using the hyperphenylalaninemia 1 (hph-1) mouse, is reported.

  12. GTPCH1 non-covalently interacts with polyubiquitin via an ubiquitin-binding domain.

  13. The data suggest that GCH1 inhibition reduces tumor growth by (i) direct killing of tumor cells, (ii) by inhibiting angiogenesis, and (iii) by enhancing the antitumoral immune response

  14. Data indicate that myocardial nitric oxide synthase 1 (NOS1) activity was increased in GCH1 transgenic mice (mGCH1-Tg).

  15. GCH1 expression and BH4 are novel determinants of cardiac autonomic regulation that may have important roles in cardiovascular pathophysiology.

  16. The hph-1 mutant mouse has deficient GTP cyclohydrolase I (GTPCH1) activity, resulting in low BH4 tissue content.

  17. Anatomical origin determines the ability of vessel wall to cope with oxidative stress induced by uncoupling of eNOS in GTP-cyclohydrolase I-deficient hph-1 mice.

  18. guanosine triphosphate cyclohydrolase-1 expression and tetrahydrobiopterin have roles in T cell activation

  19. The GTP cyclohydrolase I/tetrahydrobiopterin pathway critically regulates endothelial stem cell number and function in DOCA-salt hypertensive mice, at least in part, via suppressing thrombospondin-1 expression and oxidative stress.

  20. Studies provide a new mechanism for regulation of endothelial GTPCH-1 by its phosphorylation and interplay with GFRP.

GTP Cyclohydrolase 1 (GCH1) Antigen Profile

Protein Summary

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described\; however, not all variants give rise to a functional enzyme.

Gene names and symbols associated with GCH1

  • GTP cyclohydrolase 1 (GCH1) antibody
  • GTP cyclohydrolase 1 (Gch1) antibody
  • GTP cyclohydrolase 1 (gch1) antibody
  • GTP cyclohydrolase 1 (Weevi_1190) antibody
  • GTP cyclohydrolase 1 (Halhy_0838) antibody
  • GTP cyclohydrolase 1 (Sinme_1220) antibody
  • GTP cyclohydrolase 1 (Sphch_1077) antibody
  • GTP cyclohydrolase 1-like (LOC100136794) antibody
  • DYT5 antibody
  • DYT5a antibody
  • DYT14 antibody
  • Gch antibody
  • gch1a antibody
  • GTP-CH antibody
  • GTP-CH-1 antibody
  • GTPCH antibody
  • GTPCH1 antibody
  • HPABH4B antibody
  • MGC89622 antibody
  • wu:fc16b10 antibody
  • zgc:195269 antibody

Protein level used designations for GCH1

GTP cyclohydrolase I , GTP-CH-I , dystonia 14 , guanosine 5'-triphosphate cyclohydrolase I , GTP cyclohydrolase 1 (dopa-responsive dystonia) , GTP cyclohydrolase 1 , GTP cyclohydrolase I (form A; N-terminus)

2643 Homo sapiens
609393 Canis lupus familiaris
286815 Bos taurus
695675 Macaca mulatta
743728 Pan troglodytes
396146 Gallus gallus
14528 Mus musculus
29244 Rattus norvegicus
448485 Xenopus (Silurana) tropicalis
10282422 Weeksella virosa DSM 16922
10584999 Haliscomenobacter hydrossis DSM 1100
10725797 Sinorhizobium meliloti AK83
10741394 Sphingobium chlorophenolicum L-1
100136794 Oncorhynchus mykiss
100192219 Danio rerio
100286831 Oryctolagus cuniculus
100303455 Ovis aries
100735198 Cavia porcellus
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