GCH1 antibody (C-Term)

Catalog No. ABIN929286

Product Details anti-GCH1 Antibody

Target: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GCH1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Purified

Immunogen: GCH1 antibody was raised in rabbit using the C terminal of GCH1 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

GCH1 Blocking Peptide, catalog no. 33R-5373, is also available for use as a blocking control in assays to test for specificity of this GCH1 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for GCH1

Target: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Alternative Name: GCH1 (GCH1 Products)

Synonyms: DYT14 antibody, DYT5 antibody, DYT5a antibody, GCH antibody, GTP-CH-1 antibody, GTPCH1 antibody, HPABH4B antibody, GTP-CH antibody, GTPCH antibody, Gch antibody, MGC89622 antibody, gch1a antibody, wu:fc16b10 antibody, zgc:195269 antibody, GTP cyclohydrolase 1 antibody, GTP cyclohydrolase 1-like antibody, GCH1 antibody, Gch1 antibody, gch1 antibody, Weevi_1190 antibody, Halhy_0838 antibody, Sinme_1220 antibody, Sphch_1077 antibody, LOC100136794 antibody

Background: This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described, however, not all variants give rise to a functional enzyme. Synonyms: Polyclonal GCH1 antibody, Anti-GCH1 antibody, GTP cyclohydrolase 1 antibody, DYT14 antibody, DYT5 antibody, DYT5a antibody, GCH antibody, GTP-CH-1 antibody, GTPCH1 antibody, HPABH4B antibody.