Glial Cells Missing Homolog 1 (Drosophila) Proteins (GCM1)

GCM1 encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). Additionally we are shipping GCM1 Antibodies (51) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GCM1 8521 Q9NP62
GCM1 14531 P70348
Rat GCM1 GCM1 29394 Q9Z288
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Top GCM1 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see Available

GCM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for Glial Cells Missing Homolog 1 (Drosophila) (GCM1) Interaction Partners

Pig (Porcine) Glial Cells Missing Homolog 1 (Drosophila) (GCM1) interaction partners

  1. chromosomal localization of the porcine GCM1 gene and the identification and characterization of a GCM1 associated microsatellite marker [GCM1]

Human Glial Cells Missing Homolog 1 (Drosophila) (GCM1) interaction partners

  1. our studies demonstrate that DLX3 physically interacts with GCM1 and inhibits its transactivation activity, suggesting that DLX3 and GCM1 may form a complex to functionally regulate placental cell function through modulation of target gene expression.

  2. results suggest that p45 NF-E2 negatively regulates differentiation and apoptosis activation of human syncytiotrophoblast by modulating GCM1 acetylation and sumoylation.

  3. Identify a novel cis-acting sequence (-369 to -320) at the placental growth factor promoter, which was critical for mediating the basal and DLX3/GCM1-dependent PGF promoter activities.

  4. Twist1 may promote trophoblast syncytialization by regulating the expression of GCM1.

  5. GATA3 knockdown elevated HtrA4 expression in BeWo and JEG-3 trophoblast cell lines and enhanced the invasion activities of both lines. This study uncovered a new GATA3 function in placenta as a negative regulator of GCM1 activity and trophoblastic invasion.

  6. GLI2 stabilized glial cell missing-a, a pivotal transcriptional factor for trophoblastic syncytialization.

  7. reveals a positive feedback loop between glial cells missing 1 and Human chorionic gonadotropin regulating placental hCGbeta expression and cell differentiation

  8. Gcm1 and Fzd5 function in an evolutionary conserved positive feedback loop that regulates trophoblast differentiation and sites of chorionic branching morphogenesis.

  9. Results suggest that caspase-14 may interact with GCM1 to participate in syncytiotrophoblast differentiation during placental development.

  10. study reveals a novel function for RACK1 to regulate GCM1 activity and placental cell migration and invasion

  11. GCM1-directed villous trophoblast differentiation is repressed by DREAM

  12. c-Myc-regulated members of the miR-17~92 and miR-106a~363 clusters inhibit trophoblast differentiation by repressing GCM1 and CYP19A1.

  13. Phorbol 12-myristate 13-acetate-induced protein kinase C and mitogen-activated protein kinase kinase/extracellular signal regulated kinase dependent pathway enhances the degradation as well as the transcriptional activity of GCMa.

  14. study reveals a novel function of GCM1 and HtrA4 in regulation of trophoblast invasion and that abnormal HrtA4 expression may contribute to shallow trophoblast invasion in preeclampsia

  15. Data show that beta-catenin/BCL9-Like (BCL9L)/T-cell factor 4 (TCF4) signalling directly targets the GCM1/syncytin pathway and thereby regulates the fusion of human choriocarcinoma cells.

  16. results support a role for reduced placental Gcm1 expression as a causative factor in defective syncytiotrophoblast differentiation and maternal and placental phenotypes in preeclampsia in humans.

  17. these data demonstrate for the first time that GCMa is phosphorylated by the PKC- and MEK/extracellular signal-regulated kinase (ERK)-dependent mechanism, and that this phosphorylation is involved in its degradation process.

  18. CD9 increases GCM1 expression via the cAMP/PKA signaling pathway, resulting in the increase in ERVWE1 expression.

  19. Our study has identi fi ed a novel cAMP/Epac1/CaMKI/GCM1 signaling cascade that stimulates trophoblast fusion through promoting GCM1 phosphorylation and desumoylation.

  20. TIMP4 is a downstream target of GCM1.

Mouse (Murine) Glial Cells Missing Homolog 1 (Drosophila) (GCM1) interaction partners

  1. GCM1-directed villous trophoblast differentiation is repressed by DREAM

  2. Data show that the GCM1/syncytin-B pathway is significantly downregulated in the placenta of BCL9L-deficient mice and that the fusion and differentiation of ST-II cells are blocked.

  3. as in mice, fetoplacental vascularity increased when GCM1 protein expression decreased (R(2)=-0.45; P<0.05).

  4. Gcm1 (glial cells missing 1) are involved in the epigenetic regulation of Hes5 transcription by DNA demethylation independently of DNA replication.

  5. studies identify a novel function of p45NF-E2 during placental development: in trophoblast cells, p45NF-E2 represses Gcm1 and syncytiotrophoblast formation via acetylation

  6. Gcm1 expression defines three stages of chorio-allantoic interaction during placental development

  7. Brief ectopic expression of Gcm1 in mouse embryonic tail bud induces failure of the neural tube to close (spina bifida) and multiple neural tubes (diastematomyelia).

  8. GCM domain as a new type of Zn-coordinating, sequence-specific DNA-binding domain.

  9. mGCMa expression is primarily postnatal, arguing for a role in organ function rather than organ development

  10. the shaping of the maternal blood spaces within the labyrinth was dependent on chorioallantoic morphogenesis and therefore disrupted in Gcm1 mutants

  11. Data describe the crystal structure of the glial cell missing (GCM) domain from murine GCMa bound to its octameric DNA target site at 2.85 A resolution.

  12. Regulation of subcellular localization has important implications for GCMa/Gcm-1 function.

  13. Gcm1 promotes cell cycle exit and restriction towards the syncytiotrophoblast cell fate.

  14. Pitx proteins influence GCMa-dependent promoter activation in a cell-specific manner

  15. Identification of integrin-alpha4, Rb1, and syncytin a as murine placental target genes of the transcription factor GCMa/Gcm1

  16. Gcm1 is co-expressed with Cebpa and Synb in basal cells in contact with the allantois.

GCM1 Protein Profile

Protein Summary

This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.

Gene names and symbols associated with GCM1

  • glial cells missing homolog 1 (GCM1)
  • glial cells missing homolog 1 (Drosophila) (Gcm1)
  • glial cells missing homolog 1 (Gcm1)
  • GCM protein
  • GCM-1 protein
  • Gcm-rs2 protein
  • GCM1 protein
  • Gcm1-rs1 protein
  • Gcma protein
  • glide protein
  • hGCMa protein

Protein level used designations for GCM1

glial cells missing homolog 1 (Drosophila) , chorion-specific transcription factor GCMa , glial cells missing-like protein 1 , glial cells missing homolog a , chorion-specific transcription factor GCMa-like , GCM motif protein 1 , Gcm 1 , Gcm a , glial cell deficient , mGCM1 , mGCMa

317779 Bos taurus
404300 Gallus gallus
414910 Sus scrofa
472036 Pan troglodytes
481844 Canis lupus familiaris
709965 Macaca mulatta
100056683 Equus caballus
100341874 Oryctolagus cuniculus
100403173 Callithrix jacchus
100452572 Pongo abelii
100465515 Ailuropoda melanoleuca
100581967 Nomascus leucogenys
8521 Homo sapiens
14531 Mus musculus
29394 Rattus norvegicus
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