anti-Glutamate Receptor, Metabotropic 1 (GRM1) Antibodies

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Additionally we are shipping Metabotropic Glutamate Receptor 1 Kits (18) and Metabotropic Glutamate Receptor 1 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GRM1 2911 Q13255
GRM1 14816 P97772
GRM1 24414 P23385
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Top anti-Metabotropic Glutamate Receptor 1 Antibodies at antibodies-online.com

Showing 10 out of 173 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated ICC, IHC (fro), IF, IHC (p), IHC, WB Western blot detection of GluR1 in 20 ug of human brain lysate (lane 2) with GluR1 polyclonal at 1:1000 dilution followed by AP-conjugated secondary at 1:5000 dilution. MW marker in Lane 1. GluR1: Immunofluorescence labeling for GluR1 in rat brain (cingulate cortex). GluR1 detection  was done using anti-rabbit Cy3 conjugated antibodies (red color). DAPI was used to counterstain cell nuclei (blue color).  Working dilution is 1:100-1:500. 0.1 mg Log in to see 7 to 9 Days
$488.73
Details
Human Rabbit Un-conjugated WB Western blot analysis of mGLUR1 expression in A549 (A) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using GRM1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemistry-Paraffin: mGluR1 Antibody [NLS882] - IHC analysis of mGluR1 in formalin-fixed paraffin embedded human brain using NLS882 at 2 ug/ ml. Immunohistochemistry-Paraffin: mGluR1 Antibody  - Anti-GRM1 / MGLUR1 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 0.05 mL Log in to see 7 to 9 Days
$516.98
Details
Human Rabbit Un-conjugated WB GRM1 Antibody (C-term) (ABIN657624) western blot analysis in CEM cell line lysates (35 µg/lane). This demonstrates the GRM1 antibody detected the GRM1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC (p), WB GPRC1A Antibody (Y1111) (ABIN652203) western blot analysis in NCI-H460 cell line lysates (35 µg/lane).This demonstrates the GPRC1A antibody detected the GPRC1A protein (arrow). Metabotropic Glutamate Receptor 1 (GPRC1A) Antibody (C-term) (ABIN652203)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Anti-GRM1 / MGLUR1 antibody  ABIN1048926 IHC staining of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Cow Rabbit Un-conjugated IHC, IHC (p) Anti-GRM1 / MGLUR1 antibody  ABIN1048925 IHC staining of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-GRM1 / MGLUR1 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Rat Rabbit Un-conjugated IHC (fro), WB 10 blots Log in to see 6 to 8 Days
$599.50
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IF, IHC, WB Western Blot: metabotropic Glutamate Receptor 1a Antibody [ABIN4087595] - Detection of metabotropic Glutamate Receptor 1a protein in 20ug of human brain lysate (lane 2) with the use of ABIN4087595 as a primary antibody at 1:1000 dilution and an AP conjugated secondary antibody at 1:5000 dilution. Lane 1 represents the MW marker. 0.1 mg Log in to see 7 to 9 Days
$347.48
Details

Top referenced anti-Metabotropic Glutamate Receptor 1 Antibodies

  1. Human Polyclonal Metabotropic Glutamate Receptor 1 Primary Antibody for IHC (fro), WB - ABIN550140 : Blaabjerg, Fang, Zimmer, Baskys: Neuroprotection against NMDA excitotoxicity by group I metabotropic glutamate receptors is associated with reduction of NMDA stimulated currents. in Experimental neurology 2003 (PubMed)
    Show all 3 Pubmed References

  2. Chicken Polyclonal Metabotropic Glutamate Receptor 1 Primary Antibody for ICC, IHC (fro) - ABIN258097 : Hirdes, Napp, Wulfsen, Schweizer, Schwarz, Bauer: Erg K+ currents modulate excitability in mouse mitral/tufted neurons. in Pflügers Archiv : European journal of physiology 2009 (PubMed)
    Show all 2 Pubmed References

  3. Rat (Rattus) Polyclonal Metabotropic Glutamate Receptor 1 Primary Antibody for IHC (fro), WB - ABIN2475565 : Copani, Romano, Di Giorgi Gerevini, Nicosia, Casabona, Storto, Mutel, Nicoletti: Reducing conditions differentially affect the functional and structural properties of group-I and -II metabotropic glutamate receptors. in Brain research 2000 (PubMed)

  4. Rat (Rattus) Polyclonal Metabotropic Glutamate Receptor 1 Primary Antibody for IHC (fro), IHC - ABIN152471 : Li, Corbelli, Watanabe, Armelloni, Ikehata, Parazzi, Pignatari, Giardino, Mattinzoli, Lazzari, Puliti, Cellesi, Zennaro, Messa, Rastaldi: Three-dimensional podocyte-endothelial cell co-cultures: Assembly, validation, and application to drug testing and intercellular signaling studies. in European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2016 (PubMed)

  5. Human Polyclonal Metabotropic Glutamate Receptor 1 Primary Antibody for ICC, IHC (fro) - ABIN408759 : Coulon, Kanyshkova, Broicher, Munsch, Wettschureck, Seidenbecher, Meuth, Offermanns, Pape, Budde: Activity Modes in Thalamocortical Relay Neurons are Modulated by G(q)/G(11) Family G-proteins - Serotonergic and Glutamatergic Signaling. in Frontiers in cellular neuroscience 2011 (PubMed)

More Antibodies against Metabotropic Glutamate Receptor 1 Interaction Partners

Human Glutamate Receptor, Metabotropic 1 (GRM1) interaction partners

  1. Fyn binds to mGluR1a at a consensus binding motif located in the intracellular C-terminus (CT) of mGluR1a in vitro. Active Fyn phosphorylates mGluR1a at a conserved tyrosine residue in the CT region. In cerebellar neurons and transfected HEK293T cells, Fyn-mediated tyrosine phosphorylation of mGluR1a is constitutively active and facilitates surface expression of mGluR1a and potentiates mGluR1a postreceptor signaling.

  2. Age-dependent increase in metabotropic glutamate receptor type 1 availability in several brain regions may exist predominantly in males.

  3. Missense Mutation in GRM1 gene is associated with Spinocerebellar Ataxia Type 44.

  4. our findings suggest that pharmacological manipulation of mglur1 should be explored as an exciting new approach for the treatment of a variety of human cerebellar ataxias.

  5. a missense variant was found in GRM1 gene, while in the second family, a frameshift alteration was identified in TRMT1, both of which were found to co-segregate with the intellectual disability.

  6. It has the intrinsic ability to form a heteromeric complex with adenosine A1 receptor and mutually modulate signaling.

  7. These data demonstrate that the approaches commonly used to study mGlu1 receptor function and signaling in other systems may be inappropriate for studying mGlu1 receptor-mediated melanoma cell viability.

  8. Our results are likely relevant to human breast cancer, highlighting a putative role of mGluR1 in the pathophysiology of breast cancer and the potential of mGluR1 as a novel therapeutic target.

  9. elevated glutamate secretion and mGluR1 expression play a role in Kaposi's sarcoma associated herpesvirus induced cell proliferation

  10. alpha-actinin-4 is a novel group 1 mGluR-interacting partner that orchestrates spine dynamics and morphogenesis in neurons.

  11. Deleterious GRM1 mutations are associated with schizophrenia.

  12. These novel mutations may contribute to the disease by alterations in GRM1 gene splicing, receptor activation, and post-receptor downstream signaling.

  13. Results suggest a role for mGluR1 in breast cancer as a pro-angiogenic factor as well as a mediator of tumor progression.

  14. In mice expressing mutant beta-III spectrin, mGluR1 localization is altered at Purkinje cell dendritic spines.

  15. mGluR1 cooperates with other factors in hyperplastic mammary epithelium to contribute to TNBC progression

  16. reflected in the immunoblotting data Mglur1 receptors were detected at higher levels of expression in patient with cortical dysplasia with intractable epilepsy.

  17. GluD2 gating is triggered by type 1 metabotropic glutamate receptors.

  18. GRM1 activation triggers proangiogenic signaling in melanoma.

  19. GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma.

  20. mGluR1-dependent synaptic transmission in the cerebellum is regulated by STIM1 in neuronal Ca(2) signaling.

Mouse (Murine) Glutamate Receptor, Metabotropic 1 (GRM1) interaction partners

  1. Our results identify a key role for NRG1/ErbB signalling in the regulation of hippocampal mGluRI-dependent synaptic and cognitive functions, whose alteration might contribute to the pathogenesis of different brain diseases.

  2. Study states that metabotropic glutamate receptor subtype 1 (mGluR1) is critical for elimination of surplus climbing fiber-Purkinje cell synapses in the cerebellum, retinogeniculate synapses require mGluR1 for maintenance of mature connectivity.

  3. Study shows that blocking of metabotropic glutamate type 5 receptor (mGlu5) reduced the dysregulation of glutamate transmission and improved motor coordination in the metabotropic glutamate type 1 receptor (Grm1crv4) mouse model of cerebellar ataxia SCAR13.

  4. These findings demonstrate that mGlu1 receptors play a key role in excitotoxic degeneration of retinal ganglion cell

  5. this work reveals novel functions of mGlu1 receptors in the bone and indicates that in osteoblasts mGlu1 receptors are necessary for production of normal bone matrix, longitudinal bone growth, and normal skeletal development.

  6. mGluR1 activation at the onset of reperfusion induces cardioprotection and might represent a putative strategy to prevent ischaemia-reperfusion injury.

  7. These findings demonstrate a deleterious positive feedback loop involving elevated intracellular calcium and enhanced mGluR1 function, a mechanism likely to contribute to Purkinje neuron dysfunction and loss in spinocerebellar ataxia type 2.

  8. mouse external globus pallidus astrocytes critically control ambient glutamate level, which in turn gates striatopallidal transmission via the activation of presynaptic metabotropic glutamate receptors.

  9. The results of our study showed that thalamic mGluR1-PLCbeta4 pathway was critical in controlling sleep architecture.

  10. This study confirmed the presence of mGluR1/5 complex by (i) reverse immunoprecipitation using an mGluR1 antibody to pulldown mGluR5 from hippocampal tissue.

  11. results demonstrate that mGluR1 is crucial for the visual-experience-dependent maintenance of mature synaptic connectivity in the dorsal Lateral Geniculate Nuc.

  12. These results suggest that impairment of synaptic mGluR cascades is one of the important contributing factors to cerebellar ataxia in early and middle stages of spinocerebellar ataxia type 1 (SCA1) pathology, and that modulation of mGluR signalling by baclofen or other clinical interventions may be therapeutic targets to treat SCA1

  13. activation of mGluR1 expressed by OCCM-30 cells induces cell proliferation in a manner that is dependent on mitogen-activated protein kinase pathways.

  14. In a mouse model of human spino-cerebellar ataxia type 1 (early SCA1, 12 weeks) we find prolonged parallel fiber mGluR1-dependent synaptic currents and calcium signaling

  15. Here we identify mGluR1 and mGluR5 as key elements in the dynamic regulation of cholinergic synaptic inputs onto neurons of the TRN. Our findings highlight potential mechanisms that regulate cholinergic signaling in the mammalian brain.

  16. data suggest that Lys(63)-linked polyubiquitination is involved in the ligand-mediated endocytosis of mGluR1.

  17. This study provides evidence that ASIC1a is involved in group I metabotropic glutamate (mGlu) receptor-induced increase in action potential firing.

  18. Homodimerization enhances both sensitivity and dynamic range of the ligand-binding domain of type 1 metabotropic glutamate receptor

  19. Unpredictable chronic mild stress mice exhibited elevated nucleus accumbens (NAC) shell levels of mGlu1alpha. The expression of stress-alcohol locomotor cross-sensitization was associated with lower mGlu1alpha within the NAC core.

  20. Ionizing radiation is able to trigger the altered neuronal differentiation in undifferentiated neural stem-like cells through PI3K-STAT3-mGluR1 and PI3K-p53 signaling.

Metabotropic Glutamate Receptor 1 (GRM1) Antigen Profile

Protein Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms\; some of which may have distinct functions.

Gene names and symbols associated with GRM1

  • glutamate metabotropic receptor 1 (GRM1) antibody
  • glutamate receptor, metabotropic 1a (grm1a) antibody
  • metabotropic glutamate receptor 1 (mGlutR1) antibody
  • glutamate receptor, metabotropic 1 (Grm1) antibody
  • glutamate receptor, metabotropic 1 (GRM1) antibody
  • 4930455H15Rik antibody
  • ENSMUSG00000075319 antibody
  • fj39d05 antibody
  • GB18621 antibody
  • Glura antibody
  • Gm10828 antibody
  • Gprc1a antibody
  • MGLU1 antibody
  • mGluR1 antibody
  • mGlutR antibody
  • nmf373 antibody
  • rcw antibody
  • SCAR13 antibody
  • si:ch211-51a19.1 antibody
  • wobl antibody
  • wu:fj39d05 antibody

Protein level used designations for GRM1

metabotropic glutamate receptor 1 , metabotropic glutamate receptor A , G protein coupled receptor, family C, group 1, member A , G protein-coupled receptor, family C, group 1, member A , G protein coupled receptor family C group 1 member A , mGluR1

GENE ID SPECIES
100060603 Equus caballus
463049 Pan troglodytes
555576 Danio rerio
406151 Apis mellifera
2911 Homo sapiens
100625610 Sus scrofa
14816 Mus musculus
24414 Rattus norvegicus
421614 Gallus gallus
484024 Canis lupus familiaris
540485 Bos taurus
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