anti-Glutamate Receptor, Metabotropic 1 (GRM1) Antibodies

Human Glutamate Receptor, Metabotropic 1 (GRM1) interaction partners

1. Fyn binds to mGluR1a at a consensus binding motif located in the intracellular C-terminus (CT) of mGluR1a in vitro. Active Fyn phosphorylates mGluR1a at a conserved tyrosine residue in the CT region. In cerebellar neurons and transfected HEK293T cells, Fyn-mediated tyrosine phosphorylation of mGluR1a is constitutively active and facilitates surface expression of mGluR1a and potentiates mGluR1a postreceptor signaling.

2. Age-dependent increase in metabotropic glutamate receptor type 1 availability in several brain regions may exist predominantly in males.

3. Missense Mutation in GRM1 gene is associated with Spinocerebellar Ataxia Type 44.

4. our findings suggest that pharmacological manipulation of mglur1 should be explored as an exciting new approach for the treatment of a variety of human cerebellar ataxias.

5. a missense variant was found in GRM1 gene, while in the second family, a frameshift alteration was identified in TRMT1, both of which were found to co-segregate with the intellectual disability.

6. It has the intrinsic ability to form a heteromeric complex with adenosine A1 receptor and mutually modulate signaling.

7. These data demonstrate that the approaches commonly used to study mGlu1 receptor function and signaling in other systems may be inappropriate for studying mGlu1 receptor-mediated melanoma cell viability.

8. Our results are likely relevant to human breast cancer, highlighting a putative role of mGluR1 in the pathophysiology of breast cancer and the potential of mGluR1 as a novel therapeutic target.

9. elevated glutamate secretion and mGluR1 expression play a role in Kaposi's sarcoma associated herpesvirus induced cell proliferation

10. alpha-actinin-4 is a novel group 1 mGluR-interacting partner that orchestrates spine dynamics and morphogenesis in neurons.

11. Deleterious GRM1 mutations are associated with schizophrenia.

12. These novel mutations may contribute to the disease by alterations in GRM1 gene splicing, receptor activation, and post-receptor downstream signaling.

13. Results suggest a role for mGluR1 in breast cancer as a pro-angiogenic factor as well as a mediator of tumor progression.

14. In mice expressing mutant beta-III spectrin, mGluR1 localization is altered at Purkinje cell dendritic spines.

15. mGluR1 cooperates with other factors in hyperplastic mammary epithelium to contribute to TNBC progression

16. reflected in the immunoblotting data Mglur1 receptors were detected at higher levels of expression in patient with cortical dysplasia with intractable epilepsy.

17. GluD2 gating is triggered by type 1 metabotropic glutamate receptors.

18. GRM1 activation triggers proangiogenic signaling in melanoma.

19. GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma.

20. mGluR1-dependent synaptic transmission in the cerebellum is regulated by STIM1 in neuronal Ca(2) signaling.

Mouse (Murine) Glutamate Receptor, Metabotropic 1 (GRM1) interaction partners

1. Our results identify a key role for NRG1/ErbB signalling in the regulation of hippocampal mGluRI-dependent synaptic and cognitive functions, whose alteration might contribute to the pathogenesis of different brain diseases.

2. Study states that metabotropic glutamate receptor subtype 1 (mGluR1) is critical for elimination of surplus climbing fiber-Purkinje cell synapses in the cerebellum, retinogeniculate synapses require mGluR1 for maintenance of mature connectivity.

3. Study shows that blocking of metabotropic glutamate type 5 receptor (mGlu5) reduced the dysregulation of glutamate transmission and improved motor coordination in the metabotropic glutamate type 1 receptor (Grm1crv4) mouse model of cerebellar ataxia SCAR13.

4. These findings demonstrate that mGlu1 receptors play a key role in excitotoxic degeneration of retinal ganglion cell

5. this work reveals novel functions of mGlu1 receptors in the bone and indicates that in osteoblasts mGlu1 receptors are necessary for production of normal bone matrix, longitudinal bone growth, and normal skeletal development.

6. mGluR1 activation at the onset of reperfusion induces cardioprotection and might represent a putative strategy to prevent ischaemia-reperfusion injury.

7. These findings demonstrate a deleterious positive feedback loop involving elevated intracellular calcium and enhanced mGluR1 function, a mechanism likely to contribute to Purkinje neuron dysfunction and loss in spinocerebellar ataxia type 2.

8. mouse external globus pallidus astrocytes critically control ambient glutamate level, which in turn gates striatopallidal transmission via the activation of presynaptic metabotropic glutamate receptors.

9. The results of our study showed that thalamic mGluR1-PLCbeta4 pathway was critical in controlling sleep architecture.

10. This study confirmed the presence of mGluR1/5 complex by (i) reverse immunoprecipitation using an mGluR1 antibody to pulldown mGluR5 from hippocampal tissue.

11. results demonstrate that mGluR1 is crucial for the visual-experience-dependent maintenance of mature synaptic connectivity in the dorsal Lateral Geniculate Nuc.

12. These results suggest that impairment of synaptic mGluR cascades is one of the important contributing factors to cerebellar ataxia in early and middle stages of spinocerebellar ataxia type 1 (SCA1) pathology, and that modulation of mGluR signalling by baclofen or other clinical interventions may be therapeutic targets to treat SCA1

13. activation of mGluR1 expressed by OCCM-30 cells induces cell proliferation in a manner that is dependent on mitogen-activated protein kinase pathways.

14. In a mouse model of human spino-cerebellar ataxia type 1 (early SCA1, 12 weeks) we find prolonged parallel fiber mGluR1-dependent synaptic currents and calcium signaling

15. Here we identify mGluR1 and mGluR5 as key elements in the dynamic regulation of cholinergic synaptic inputs onto neurons of the TRN. Our findings highlight potential mechanisms that regulate cholinergic signaling in the mammalian brain.

16. data suggest that Lys(63)-linked polyubiquitination is involved in the ligand-mediated endocytosis of mGluR1.

17. This study provides evidence that ASIC1a is involved in group I metabotropic glutamate (mGlu) receptor-induced increase in action potential firing.

18. Homodimerization enhances both sensitivity and dynamic range of the ligand-binding domain of type 1 metabotropic glutamate receptor

19. Unpredictable chronic mild stress mice exhibited elevated nucleus accumbens (NAC) shell levels of mGlu1alpha. The expression of stress-alcohol locomotor cross-sensitization was associated with lower mGlu1alpha within the NAC core.

20. Ionizing radiation is able to trigger the altered neuronal differentiation in undifferentiated neural stem-like cells through PI3K-STAT3-mGluR1 and PI3K-p53 signaling.