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anti-Glutamate Receptor, Metabotropic 1 (GRM1) Antibodies

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Additionally we are shipping Metabotropic Glutamate Receptor 1 Kits (15) and Metabotropic Glutamate Receptor 1 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GRM1 2911 Q13255
GRM1 14816 P97772
GRM1 24414 P23385
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Top anti-Metabotropic Glutamate Receptor 1 Antibodies at antibodies-online.com

Showing 10 out of 136 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse FITC FACS, IP Surface staining of human peripheral blood cells with anti-CD16 (LNK16) PE. 100 Tests Log in to see 5 to 7 Days
$316.25
Details
Human Mouse PE FACS, IP Surface staining of human peripheral blood cells with anti-CD16 (LNK16) PE. 100 Tests Log in to see 5 to 7 Days
$366.85
Details
Human Mouse Un-conjugated FACS, IP Surface staining of human peripheral blood cells with anti-CD16 (LNK16) PE. 0.1 mg Log in to see 5 to 7 Days
$253.00
Details
Human Rabbit Un-conjugated FACS, IP, IHC, WB Western blot analysis of rat brain lysate: 1. Anti-mGluR1 (extracellular) antibody, (1:200). 2. Anti-mGluR1 (extracellular) antibody, preincubated with the control peptide antigen. Western blot analysis of mouse brain lysate: 1. Anti-mGluR1 (extracellular) antibody, (1:200). 2. Anti-mGluR1 (extracellular) antibody, preincubated with the control peptide antigen. 50 μL Log in to see 10 to 11 Days
$678.57
Details
Human Rabbit Un-conjugated WB Western blot analysis of mGLUR1 expression in A549 (A) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using GRM1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemistry-Paraffin: mGluR1 Antibody [NLS882] - IHC analysis of mGluR1 in formalin-fixed paraffin embedded human brain using NLS882 at 2 ug/ ml. Immunohistochemistry-Paraffin: mGluR1 Antibody - Anti-GRM1 / MGLUR1 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 0.05 mL Log in to see 7 to 9 Days
$514.63
Details
Mouse Mouse Un-conjugated IF, WB Western blot analysis of mGluR1 on a rat cerebrum lysate. Lane 1: 1:2500, lane 2: 1:5000, lane 3: 1: 10,000 dilution of the mouse anti-mGluR1 antibody. Immunofluorescence staining of cortical neurons. 50 μg Log in to see 6 to 8 Days
$168.74
Details
Human Rabbit Un-conjugated WB GRM1 Antibody (C-term) (ABIN657624) western blot analysis in CEM cell line lysates (35 µg/lane). This demonstrates the GRM1 antibody detected the GRM1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB GPRC1A Antibody (Y1111) (ABIN652203) western blot analysis in NCI-H460 cell line lysates (35 µg/lane).This demonstrates the GPRC1A antibody detected the GPRC1A protein (arrow). Metabotropic Glutamate Receptor 1 (GPRC1A) Antibody (C-term) (ABIN652203)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details

GRM1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Metabotropic Glutamate Receptor 1 Antibodies

  1. Human Monoclonal Metabotropic Glutamate Receptor 1 Primary Antibody for FACS, Func - ABIN1027684 : Zhu, Hamann, Muñoz, Rubio, Mayer, Hernrreiter, Leff: Intracellular expression of Fc gamma RIII (CD16) and its mobilization by chemoattractants in human eosinophils. in Journal of immunology (Baltimore, Md. : 1950) 1998 (PubMed)
    Show all 7 Pubmed References

  2. Human Monoclonal Metabotropic Glutamate Receptor 1 Primary Antibody for FACS, Func - ABIN780366 : Choi, Wang, Peterson, Letvin, Reimann: Use of an anti-CD16 antibody for in vivo depletion of natural killer cells in rhesus macaques. in Immunology 2008 (PubMed)
    Show all 6 Pubmed References

  3. Human Monoclonal Metabotropic Glutamate Receptor 1 Primary Antibody for FACS, Func - ABIN807922 : Metes, Ernst, Chambers, Sulica, Herberman, Morel: Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene. in Blood 1998 (PubMed)
    Show all 7 Pubmed References

  4. Mouse (Murine) Monoclonal Metabotropic Glutamate Receptor 1 Primary Antibody for IF, WB - ABIN968281 : Gomeza, Joly, Kuhn, Knöpfel, Bockaert, Pin: The second intracellular loop of metabotropic glutamate receptor 1 cooperates with the other intracellular domains to control coupling to G-proteins. in The Journal of biological chemistry 1996 (PubMed)
    Show all 5 Pubmed References

  5. Mouse (Murine) Monoclonal Metabotropic Glutamate Receptor 1 Primary Antibody for IF, WB - ABIN968280 : Kryl, Yacoubian, Haapasalo, Castren, Lo, Barker: Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1999 (PubMed)
    Show all 5 Pubmed References

  6. Human Monoclonal Metabotropic Glutamate Receptor 1 Primary Antibody for FACS, IP - ABIN93989 : Kahn, Moergelin, Shannon, Norrby-Teglund, Herwald, Olin, Bjoerck: Antibodies against a surface protein of Streptococcus pyogenes promote a pathological inflammatory response. in PLoS pathogens 2008 (PubMed)
    Show all 14 Pubmed References

  7. Human Monoclonal Metabotropic Glutamate Receptor 1 Primary Antibody for FACS, IP - ABIN93988 : Mathison, Christie, Davison: The tripeptide feG inhibits leukocyte adhesion. in Journal of inflammation (London, England) 2008 (PubMed)
    Show all 14 Pubmed References

  8. Human Monoclonal Metabotropic Glutamate Receptor 1 Primary Antibody for FACS, IP - ABIN93990 : Meknache, Joensson, Laurent, Guinnepain, Daueron: Human basophils express the glycosylphosphatidylinositol-anchored low-affinity IgG receptor FcgammaRIIIB (CD16B). in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)
    Show all 14 Pubmed References

  9. Human Monoclonal Metabotropic Glutamate Receptor 1 Primary Antibody for FACS - ABIN93997 : Drbal, Moertelmaier, Holzhauser, Muhammad, Fuertbauer, Howorka, Hinterberger, Stockinger, Schütz: Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement. in International immunology 2007 (PubMed)
    Show all 4 Pubmed References

More Antibodies against Metabotropic Glutamate Receptor 1 Interaction Partners

Human Glutamate Receptor, Metabotropic 1 (GRM1) interaction partners

  1. Age-dependent increase in metabotropic glutamate (show GRIN1 Antibodies) receptor type 1 availability in several brain regions may exist predominantly in males.

  2. Missense Mutation in GRM1 gene is associated with Spinocerebellar Ataxia Type 44.

  3. our findings suggest that pharmacological manipulation of mglur1 should be explored as an exciting new approach for the treatment of a variety of human cerebellar ataxias.

  4. a missense variant was found in GRM1 gene, while in the second family, a frameshift alteration was identified in TRMT1 (show TRMT1 Antibodies), both of which were found to co-segregate with the intellectual disability.

  5. It has the intrinsic ability to form a heteromeric complex with adenosine A1 receptor (show ADORA1 Antibodies) and mutually modulate signaling.

  6. These data demonstrate that the approaches commonly used to study mGlu1 receptor function and signaling in other systems may be inappropriate for studying mGlu1 receptor-mediated melanoma cell viability.

  7. Our results are likely relevant to human breast cancer, highlighting a putative role of mGluR1 in the pathophysiology of breast cancer and the potential of mGluR1 as a novel therapeutic target.

  8. elevated glutamate (show GRIN1 Antibodies) secretion and mGluR1 expression play a role in Kaposi's sarcoma associated herpesvirus induced cell proliferation

  9. alpha-actinin-4 (show ACTN4 Antibodies) is a novel group 1 mGluR (show GRM8 Antibodies)-interacting partner that orchestrates spine dynamics and morphogenesis in neurons.

  10. Deleterious GRM1 mutations are associated with schizophrenia.

Mouse (Murine) Glutamate Receptor, Metabotropic 1 (GRM1) interaction partners

  1. mGluR1 activation at the onset of reperfusion induces cardioprotection and might represent a putative strategy to prevent ischaemia-reperfusion injury.

  2. These findings demonstrate a deleterious positive feedback loop involving elevated intracellular calcium and enhanced mGluR1 function, a mechanism likely to contribute to Purkinje neuron dysfunction and loss in spinocerebellar ataxia type 2.

  3. mouse external globus pallidus astrocytes critically control ambient glutamate (show GRIN1 Antibodies) level, which in turn gates striatopallidal transmission via the activation of presynaptic metabotropic glutamate (show GRIN1 Antibodies) receptors.

  4. The results of our study showed that thalamic mGluR1-PLCbeta4 pathway was critical in controlling sleep architecture.

  5. This study confirmed the presence of mGluR1/5 complex by (i) reverse immunoprecipitation using an mGluR1 antibody to pulldown mGluR5 (show GRM5 Antibodies) from hippocampal tissue.

  6. results demonstrate that mGluR1 is crucial for the visual-experience-dependent maintenance of mature synaptic connectivity in the dorsal Lateral Geniculate Nuc.

  7. These results suggest that impairment of synaptic mGluR (show GRM8 Antibodies) cascades is one of the important contributing factors to cerebellar ataxia in early and middle stages of spinocerebellar ataxia type 1 (SCA1 (show ATXN1 Antibodies)) pathology, and that modulation of mGluR (show GRM8 Antibodies) signalling by baclofen or other clinical interventions may be therapeutic targets to treat SCA1 (show ATXN1 Antibodies)

  8. activation of mGluR1 expressed by OCCM (show LAMC3 Antibodies)-30 cells induces cell proliferation in a manner that is dependent on mitogen-activated protein kinase (show MAPK1 Antibodies) pathways.

  9. In a mouse model of human spino (show PPP1R9B Antibodies)-cerebellar ataxia type 1 (early SCA1 (show ATXN1 Antibodies), 12 weeks) we find prolonged parallel fiber mGluR1-dependent synaptic currents and calcium signaling

  10. Here we identify mGluR1 and mGluR5 (show GRM5 Antibodies) as key elements in the dynamic regulation of cholinergic synaptic inputs onto neurons of the TRN (show TNPO1 Antibodies). Our findings highlight potential mechanisms that regulate cholinergic signaling in the mammalian brain.

Metabotropic Glutamate Receptor 1 (GRM1) Antigen Profile

Protein Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms\; some of which may have distinct functions.

Gene names and symbols associated with GRM1

  • glutamate metabotropic receptor 1 (GRM1) antibody
  • glutamate receptor, metabotropic 1a (grm1a) antibody
  • metabotropic glutamate receptor 1 (mGlutR1) antibody
  • glutamate receptor, metabotropic 1 (Grm1) antibody
  • glutamate receptor, metabotropic 1 (GRM1) antibody
  • 4930455H15Rik antibody
  • ENSMUSG00000075319 antibody
  • fj39d05 antibody
  • GB18621 antibody
  • Glura antibody
  • Gm10828 antibody
  • Gprc1a antibody
  • MGLU1 antibody
  • mGluR1 antibody
  • mGlutR antibody
  • nmf373 antibody
  • rcw antibody
  • SCAR13 antibody
  • si:ch211-51a19.1 antibody
  • wobl antibody
  • wu:fj39d05 antibody

Protein level used designations for GRM1

metabotropic glutamate receptor 1 , metabotropic glutamate receptor A , G protein coupled receptor, family C, group 1, member A , G protein-coupled receptor, family C, group 1, member A , G protein coupled receptor family C group 1 member A , mGluR1

GENE ID SPECIES
100060603 Equus caballus
463049 Pan troglodytes
555576 Danio rerio
406151 Apis mellifera
2911 Homo sapiens
100625610 Sus scrofa
14816 Mus musculus
24414 Rattus norvegicus
421614 Gallus gallus
484024 Canis lupus familiaris
540485 Bos taurus
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