anti-Metabotropic Glutamate Receptor 1 Antibodies

Protein Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms\; some of which may have distinct functions.

Gene names and symbols associated with GRM1

• glutamate metabotropic receptor 1 (GRM1) antibody
• glutamate receptor, metabotropic 1a (grm1a) antibody
• metabotropic glutamate receptor 1 (mGlutR1) antibody
• glutamate receptor, metabotropic 1 (Grm1) antibody
• glutamate receptor, metabotropic 1 (GRM1) antibody

• 4930455H15Rik antibody
• ENSMUSG00000075319 antibody
• fj39d05 antibody
• GB18621 antibody
• Glura antibody
• Show all synonym aliases
• Gm10828 antibody
• Gprc1a antibody
• MGLU1 antibody
• mGluR1 antibody
• mGlutR antibody
• nmf373 antibody
• rcw antibody
• SCAR13 antibody
• si:ch211-51a19.1 antibody
• wobl antibody
• wu:fj39d05 antibody

Protein level used designations for GRM1

metabotropic glutamate receptor 1 , metabotropic glutamate receptor A , G protein coupled receptor, family C, group 1, member A , G protein-coupled receptor, family C, group 1, member A , G protein coupled receptor family C group 1 member A , mGluR1