anti-Glutamate Receptor, Metabotropic 4 (GRM4) Antibodies

Human Glutamate Receptor, Metabotropic 4 (GRM4) interaction partners

1. EGR1 and CTCF are probably involved in the transcriptional regulation of GRM4, which participates in the progress of osteosarcoma by interacting with chemokines and their receptors.

2. Results suggest that variant rs2229901 of glutamate receptor 4 is associated with major depressive disorder risk. This variant probably impacts the interaction between GRM4 and miR-1202.

3. Our data suggest that GRM4 gene polymorphism is closely related to the morbidity and metastasis of osteosarcoma in a Chinese population.

4. The GRM4 gene polymorphism was associated with the susceptibility and metastasis of osteosarcoma in a Chinese Han population.

5. study found that only one of the five SNPs tested showed a moderate but statistically significant association with juvenile myoclonic epilepsy in an Indian population

6. The major depression subjects exhibited significantly higher expression level in the metabotropic receptor genes GRM4 in Locus coeruleus neurons.

7. explored the relationship between the binding pockets of mGlu4-positive allosteric modulators with different chemical scaffolds and their functional properties

8. Data show that mGlu2 and mGlu4 subunits (but not mGlu2 and mGlu1) can heteromerize.

9. GRM4 sequence variants might confer low-risk effects to the etiology of idiopathic generalized epilepsies.

10. residues shaping the binding pocket determine ligand selectivity for mGLUR4

11. mGluR4 has a role in 5-FU resistance in colonic neoplasms

12. Results suggest that overexpression of mGluR4 is associated with poor prognosis.

13. mGluR4 internalization and desensitization are agonist-independent unless pathways leading to the activation of PKC are induced.

14. These data suggest that mGlu4 receptor enhancers are promising drugs for the treatment of medulloblastomas.

15. the effects of P-Ser (inhibition of neural stem cell proliferation and self-renewal, enhanced neurogenic fate commitment, and improved neuronal survival) are mediated bymGluR4.

Mouse (Murine) Glutamate Receptor, Metabotropic 4 (GRM4) interaction partners

1. This immuno-electron microscopic studies suggest that pre-synaptic metabotropic glutamate receptor 4 (mGluR4) in striatal glutamatergic terminals is expressed almost exclusively in cortical boutons to subserve regulatory influences upon a large contingent of corticostriatal terminals that preferentially target putative "indirect" pathway striatal projection neurons in mice.

2. Study assessed the actions of the first mGlur4-selective orthosteric agonist, LSP4-2022, in several tests reflecting positive, negative, and cognitive symptoms of schizophrenia; results suggest that the interplay between mGlu4 and GABAB receptors may become the basis for a novel therapy for schizophrenic patients with predomination of positive symptoms

3. Results offer the first evidence that changes in the striatal expression of mGlu4 and mGlu5 receptors occur in acute models of parkinsonisms

4. Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice

5. A functional hetero-complex is formed with mGluR2 and mGluR4 in central nervous system.

6. mGluR4-/- mice show increased long-term potentiation in hippocampal CA1 region and improved maze learning.

7. data support a role for mGluR4 signaling in acquisition of fear learning and memory.

8. The expression of mGluR4 is down-regulated in the cardiomyocyte differentiation of embryonic stem cells.

9. These data indicate that effects of mGluR4 on sensorimotor function and measures of anxiety, but not cued fear conditioning, are critically modulated by sex and age.

10. A role for mGlu4 was found whereby simultaneous activation with GABA(A) receptors acts to amplify glutamate release at parallel fiber-Purkinje cell synapses.

11. These data indicate that activation of mGlu4 receptors limit the development of brain damage after permanent or transient focal ischemia

12. Grm4 modulates adaptive immunity and restrains neuroinflammation.

13. The most intense mGluR4 labelling was in the cerebellar cortex, basal ganglia, the sensory relay nuclei of the thalamus, and some hippocampal areas. Immunolabelling was most intense in presynaptic active zones.

14. These data suggest that mGlu4 receptor enhancers are promising drugs for the treatment of medulloblastomas.

15. mGluR4 and mGluR7 were located close to bipolar cell ribbons

16. Our results suggest a role for mGluR1 in promoting seizure susceptibility as well as for mGluR4 to counteract excitatory activity and seizure-associated vulnerability of hippocampal neurons.

17. Conclude that mGlu4/5 receptor subtypes regulate neuronal differentiation of embryonic stem cells in a context-dependent manner.