anti-Glutamate Receptor, Metabotropic 4 (GRM4) Antibodies

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Additionally we are shipping Metabotropic Glutamate Receptor 4 Kits (14) and Metabotropic Glutamate Receptor 4 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GRM4 2914 Q14833
GRM4 268934 Q68EF4
GRM4 24417 P31423
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Top anti-Metabotropic Glutamate Receptor 4 Antibodies at antibodies-online.com

Showing 10 out of 50 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of mGLUR4 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of mGLUR4 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from 293 cells, treated with Forskolin 40nM 30', using mGluR4 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using mGluR4 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western Blot (WB) analysis of specific cells using mGluR-4 Polyclonal Antibody. 100 μL Log in to see Available
$363.46
Details
Cow Rabbit Un-conjugated IHC, IHC (p) Anti-GRM4 / MGLUR4 antibody  ABIN1048936 IHC staining of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-GRM4 / MGLUR4 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Anti-MGLUR4 antibody IHC staining of human brain, cortex, neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1048935 dilution 19 ug/ml. Anti-MGLUR4 antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1048935 dilution 19 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Anti-GRM4 / MGLUR4 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1101897 concentration 10 ug/ml. 50 μL Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB Western blot analysis on 293 cell lysate using mGluR4 Antibody,The lane on the left is treated with the antigen-specific peptide. ABIN6266548 staining 293 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Cow Rabbit Un-conjugated IHC (p) Immunohistochemistry-Paraffin: mGluR4 Antibody  - Analysis of anti-GRM4 / MGLUR4 antibody with human brain, glioblastoma. Immunohistochemistry-Paraffin: mGluR4 Antibody  - Analysis of anti-GRM4 / MGLUR4 antibody with human brain, neurons and glia. 0.05 mL Log in to see 7 to 9 Days
$516.98
Details
Human Sheep Un-conjugated CyTOF, FACS, IHC Detection of mGluR4 in HT1080 Human Cell Line by Flow Cytometry. mGluR4 in Human Endothelial Cells. mGluR4 was detected in immersion fixed paraffin-embedded sections of human brainstem (medulla) using Sheep Anti-Human mGluR4 Antigen Affinity-purified Polyclonal Antibody  at 1.7 ug/mL overnight at 4 ᄚC. Tissue was stained using the Anti-Sheep HRP-DAB Cell & 100 μg Log in to see 8 to 9 Days
$300.58
Details
Human Rabbit Un-conjugated IHC (p), WB Immunohistochemistry-Paraffin: mGluR4 Antibody [NLS4713] - Analysis of anti-MGLUR4 antibody with human brain, cortex, neurons at dilution 19 ug/ml. Immunohistochemistry-Paraffin: mGluR4 Antibody  - Anti-MGLUR4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 19 ug/ml. 0.05 mL Log in to see 10 to 13 Days
$516.98
Details

More Antibodies against Metabotropic Glutamate Receptor 4 Interaction Partners

Human Glutamate Receptor, Metabotropic 4 (GRM4) interaction partners

  1. EGR1 and CTCF are probably involved in the transcriptional regulation of GRM4, which participates in the progress of osteosarcoma by interacting with chemokines and their receptors.

  2. Results suggest that variant rs2229901 of glutamate receptor 4 is associated with major depressive disorder risk. This variant probably impacts the interaction between GRM4 and miR-1202.

  3. Our data suggest that GRM4 gene polymorphism is closely related to the morbidity and metastasis of osteosarcoma in a Chinese population.

  4. The GRM4 gene polymorphism was associated with the susceptibility and metastasis of osteosarcoma in a Chinese Han population.

  5. study found that only one of the five SNPs tested showed a moderate but statistically significant association with juvenile myoclonic epilepsy in an Indian population

  6. The major depression subjects exhibited significantly higher expression level in the metabotropic receptor genes GRM4 in Locus coeruleus neurons.

  7. explored the relationship between the binding pockets of mGlu4-positive allosteric modulators with different chemical scaffolds and their functional properties

  8. Data show that mGlu2 and mGlu4 subunits (but not mGlu2 and mGlu1) can heteromerize.

  9. GRM4 sequence variants might confer low-risk effects to the etiology of idiopathic generalized epilepsies.

  10. residues shaping the binding pocket determine ligand selectivity for mGLUR4

  11. mGluR4 has a role in 5-FU resistance in colonic neoplasms

  12. Results suggest that overexpression of mGluR4 is associated with poor prognosis.

  13. mGluR4 internalization and desensitization are agonist-independent unless pathways leading to the activation of PKC are induced.

  14. These data suggest that mGlu4 receptor enhancers are promising drugs for the treatment of medulloblastomas.

  15. the effects of P-Ser (inhibition of neural stem cell proliferation and self-renewal, enhanced neurogenic fate commitment, and improved neuronal survival) are mediated bymGluR4.

Mouse (Murine) Glutamate Receptor, Metabotropic 4 (GRM4) interaction partners

  1. This immuno-electron microscopic studies suggest that pre-synaptic metabotropic glutamate receptor 4 (mGluR4) in striatal glutamatergic terminals is expressed almost exclusively in cortical boutons to subserve regulatory influences upon a large contingent of corticostriatal terminals that preferentially target putative "indirect" pathway striatal projection neurons in mice.

  2. Study assessed the actions of the first mGlur4-selective orthosteric agonist, LSP4-2022, in several tests reflecting positive, negative, and cognitive symptoms of schizophrenia; results suggest that the interplay between mGlu4 and GABAB receptors may become the basis for a novel therapy for schizophrenic patients with predomination of positive symptoms

  3. Results offer the first evidence that changes in the striatal expression of mGlu4 and mGlu5 receptors occur in acute models of parkinsonisms

  4. Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice

  5. A functional hetero-complex is formed with mGluR2 and mGluR4 in central nervous system.

  6. mGluR4-/- mice show increased long-term potentiation in hippocampal CA1 region and improved maze learning.

  7. data support a role for mGluR4 signaling in acquisition of fear learning and memory.

  8. The expression of mGluR4 is down-regulated in the cardiomyocyte differentiation of embryonic stem cells.

  9. These data indicate that effects of mGluR4 on sensorimotor function and measures of anxiety, but not cued fear conditioning, are critically modulated by sex and age.

  10. A role for mGlu4 was found whereby simultaneous activation with GABA(A) receptors acts to amplify glutamate release at parallel fiber-Purkinje cell synapses.

  11. These data indicate that activation of mGlu4 receptors limit the development of brain damage after permanent or transient focal ischemia

  12. Grm4 modulates adaptive immunity and restrains neuroinflammation.

  13. The most intense mGluR4 labelling was in the cerebellar cortex, basal ganglia, the sensory relay nuclei of the thalamus, and some hippocampal areas. Immunolabelling was most intense in presynaptic active zones.

  14. These data suggest that mGlu4 receptor enhancers are promising drugs for the treatment of medulloblastomas.

  15. mGluR4 and mGluR7 were located close to bipolar cell ribbons

  16. Our results suggest a role for mGluR1 in promoting seizure susceptibility as well as for mGluR4 to counteract excitatory activity and seizure-associated vulnerability of hippocampal neurons.

  17. Conclude that mGlu4/5 receptor subtypes regulate neuronal differentiation of embryonic stem cells in a context-dependent manner.

Metabotropic Glutamate Receptor 4 (GRM4) Antigen Profile

Protein Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GRM4

  • glutamate metabotropic receptor 4 (GRM4) antibody
  • glutamate receptor, metabotropic 4 (Grm4) antibody
  • glutamate metabotropic receptor 4 (Grm4) antibody
  • glutamate receptor, metabotropic 4 (GRM4) antibody
  • Gprc1d antibody
  • mGlu4 antibody
  • mGluR4 antibody

Protein level used designations for GRM4

metabotropic glutamate receptor 4 , G protein-coupled receptor GRM4 , G protein-coupled receptor, family C, group 1, member D , mGluR4

GENE ID SPECIES
2914 Homo sapiens
268934 Mus musculus
24417 Rattus norvegicus
100152616 Sus scrofa
101119427 Ovis aries
481749 Canis lupus familiaris
419906 Gallus gallus
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