anti-Glycoprotein VI (Platelet) (GP6) Antibodies

GP6 encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. Additionally we are shipping GP6 Kits (41) and GP6 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GP6 51206 Q9HCN6
GP6 243816 P0C191
GP6 684555  
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Top anti-GP6 Antibodies at antibodies-online.com

Showing 10 out of 73 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-GP6 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Jurkat cell lysate 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg 4 to 8 Days
$522.50
Details
Human Rabbit Un-conjugated FACS, WB GP6 Antibody (C-term) (ABIN651878) western blot analysis in K562 cell line lysates (15 µg/lane). This demonstrates the GP6 antibody detected the GP6 protein (arrow). GP6 Antibody (C-term) (ABIN651878) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB   0.1 mg 4 to 8 Days
$522.50
Details
Human Rabbit Un-conjugated IHC, WB 0.1 mg 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Human Jurkat cell lysate; Primary Ab: 1.5µg/ml Rabbit Anti-Human GP6 Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) 100 μg 15 to 18 Days
$332.00
Details
Human Rabbit Un-conjugated WB 0.1 mg 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL 2 to 3 Days
$446.88
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μg 11 to 14 Days
$793.83
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg 15 to 19 Days
$527.03
Details

Top referenced anti-GP6 Antibodies

  1. Human Polyclonal GP6 Primary Antibody for WB - ABIN541742 : Clemetson, Polgar, Magnenat, Wells, Clemetson: The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors. in The Journal of biological chemistry 1999 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal GP6 Primary Antibody for WB - ABIN541743 : Jandrot-Perrus, Busfield, Lagrue, Xiong, Debili, Chickering, Le Couedic, Goodearl, Dussault, Fraser, Vainchenker, Villeval: Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily. in Blood 2000 (PubMed)
    Show all 3 Pubmed References

  3. Mouse (Murine) Monoclonal GP6 Primary Antibody for FACS - ABIN4896696 : Lindsey, Jiang, Woulfe, Papoutsakis: Platelets from mice lacking the aryl hydrocarbon receptor exhibit defective collagen-dependent signaling. in Journal of thrombosis and haemostasis : JTH 2014 (PubMed)

More Antibodies against GP6 Interaction Partners

Human Glycoprotein VI (Platelet) (GP6) interaction partners

  1. GPVI haplotypes influence platelet microparticle levels in the circulation and are predictive of sepsis severity in pediatric patients.

  2. Platelets drive venous thrombus propagation in a glycoprotein VI/red blood cell dependent manner regulated by hemodynamics.

  3. Only dimeric GPVI interacts with fibrinogen D-domain, at a site proximate to its collagen binding site, to support platelet adhesion/activation/aggregate formation on immobilized fibrinogen and polymerized fibrin.

  4. GPVI activation causes platelet protein ubiquitylation and post-translational modification of signalling proteins

  5. sGPVI is an important platelet-specific marker for platelet activation that predicts sepsis progression and mortality in injured patients.

  6. there is an altered activation state of GPVI signaling in ST-elevation myocardial infarction patients; GPVI is critical for the formation of arterial thrombosis in vivo

  7. haplotype PEAN associated with SPS and manifested by fetal loss and suggest that the mechanism involved in the action of GPVI has significant effect on GPVI-mediated signal transduction through Syk-phosphorylation.

  8. This suggests whereas platelet receptor shedding is mainly modulated by calcium-dependent signals, either platelet-surface interactions with the container walls during storage or induced shear stress under long-term agitation, might be also involved in the excessive shedding of GPVI during the storage of PRP-platelet concentrates.

  9. There was no evidence to suggest that polymorphisms of GP VI T13254C and GP Ibalpha VNTR were associated with CAD.

  10. Platelet adhesion to collagen induces GPVI dimer clustering. GPVI clustering increases both avidity for collagen and the proximity of GPVI-associated signaling molecules, which may be crucial for the initiation and persistence of signaling

  11. Loss of the platelet surface receptors GPIbalpha and GPVI in heart failure, CF-VAD and ECMO patients may contribute to ablated platelet adhesion/activation, and limit thrombus formation under high/pathologic shear conditions

  12. SGPVI was significantly lower in patients treated with NOACs.

  13. Novel antithrombotic peptides derived from trowaglerix that acts through GPVI antagonism with greater safety-no severe bleeding.

  14. rs1613662 polymorphism has an important role in the development of venous thromboembolism in the white race

  15. plasma sGPVI levels are related to platelet activation in Living Donor Liver Transplantation. Although the plasma levels of sGPVI in the survivors increased after the operation, those in the nonsurvivors were high only on day 3.

  16. results support the idea that genetic variability of GP6 regulatory regions can be associated with platelet hyperaggregability - a possible cause of miscarriage

  17. These results demonstrate that GP6 is a receptor for fibrin and provide evidence that this interaction contributes to thrombus growth and stability.

  18. data suggest a novel role for FAK in GPVI-dependent ROS formation and platelet activation and elucidate a proximal signaling role for FAK within the GPVI pathway.

  19. As sCD147 strongly correlates with platelet-specific sGPVI, a common platelet source and/or mechanism of release may contribute to sCD147 levels in vivo.

  20. This study identifies GPVI as a platelet receptor for polymerized fibrin with 2 major functions: (1) amplification of thrombin generation and (2) recruitment of circulating platelets to clots.

Mouse (Murine) Glycoprotein VI (Platelet) (GP6) interaction partners

  1. these results indicate that the GPVI-ITAM signaling machinery in NFYPs after antibody-mediated thrombocytopenia only becomes fully functional in the blood circulation.

  2. Loss of GPVI expression is associated with pneumonia-derived sepsis.

  3. Platelet-specific deletion of GPVI does not lead to enhanced systemic inflammation and accelerated organ injury in two mouse models of sepsis

  4. Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation.

  5. In conclusion, the present study unraveled ceramidase as a crucial player in sphingosine-induced platelet activation following GPVI-dependent signaling.

  6. These results reveal a novel and unexpected function of hepatic Fc-gamma-RIIB in the targeted downregulation of GPVI in vivo.

  7. collagen-I-mediated inhibition of proplatelet formation is specifically controlled by GPVI.

  8. platelet GP6 and thromboxane A2 receptor have a role in promoting inflammatory macrophage phenotype in skin inflammation

  9. Novel antithrombotic peptides derived from trowaglerix that acts through GPVI antagonism with greater safety-no severe bleeding.

  10. TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk.

  11. Inhibition of platelet activation by an anti-GPVI antibody significantly reduces infarct size.

  12. These results demonstrate that GPVI is a receptor for fibrin and provide evidence that this interaction contributes to thrombus growth and stability.

  13. data demonstrate that genetic deletion of GPVI receptor, FcRgamma chain, or the alpha2beta1 integrin changes the thrombotic potentials of these platelets to collagen dependent on the stimulus mechanism.

  14. data suggest a novel role for FAK in GPVI-dependent ROS formation and platelet activation and elucidate a proximal signaling role for FAK within the GPVI pathway.

  15. our results show that GPVI plays a dual role in inflammation by enhancing neutrophil-damaging activities while supporting the activation and hemostatic adhesion of single platelets to neutrophil-induced vascular breaches.

  16. This study identifies GPVI as a platelet receptor for polymerized fibrin with 2 major functions: (1) amplification of thrombin generation and (2) recruitment of circulating platelets to clots.

  17. Functional studies of platelets from Ceacam2(-/-)-deficient mice (Cc2(-/-)) revealed that CEACAM2 serves to negatively regulate collagen glycoprotein VI (platelet) (GPVI)-FcRgamma-chain and the C-type lectinlike receptor 2 (CLEC-2) signaling

  18. Glaucocalyxin A inhibits platelet activation and thrombus formation preferentially via GPVI signaling pathway.

  19. a delayed and markedly reduced thrombogenic response was still evident in VWF(-/-), GPVI, and alpha2beta1 blocked animals, suggesting that alternative primary hemostatic mechanisms can partially rescue the bleeding phenotype associated with these defects.

  20. RhoG is expressed and activated in platelets, plays an important role in GPVI-Fc receptor gamma-chain complex-mediated platelet activation, and is critical for thrombus formation in vivo.

GP6 Antigen Profile

Protein Summary

This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with GP6

  • glycoprotein VI platelet (GP6) antibody
  • glycoprotein 6 (platelet) (Gp6) antibody
  • glycoprotein VI (Gp6) antibody
  • glycoprotein VI platelet (Gp6) antibody
  • platelet glycoprotein VI (LOC103346235) antibody
  • 9830166G18Rik antibody
  • BDPLT11 antibody
  • Gm469 antibody
  • GP6 antibody
  • GPIV antibody
  • Gpvi antibody

Protein level used designations for GP6

glycoprotein 6 , platelet collagen receptor , platelet glycoprotein VI , glycoprotein VI (platelet) , glycoprotein 5 , glycoprotein 6 (platelet) , glycoprotein VI

GENE ID SPECIES
51206 Homo sapiens
456429 Pan troglodytes
484303 Canis lupus familiaris
243816 Mus musculus
101123066 Ovis aries
684555 Rattus norvegicus
106026629 Cavia porcellus
103346235 Oryctolagus cuniculus
100517829 Sus scrofa
102188249 Capra hircus
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