Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 3 Proteins (GGA3)

GGA3 encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. Additionally we are shipping GGA3 Antibodies (63) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GGA3 260302 Q8BMI3
Rat GGA3 GGA3 360658  
GGA3 23163 Q9NZ52
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Top GGA3 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
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Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
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GGA3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

More Proteins for Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 3 (GGA3) Interaction Partners

Mouse (Murine) Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 3 (GGA3) interaction partners

  1. GGA3 plays a key role in GABAergic transmission. GGA3 deletion results in decreased anxiety-like behaviors and increased BACE1 levels.

  2. depletion of GGA1 and GGA3 engender a rapid and robust elevation of BACE1 in the acute phase after brain injury. However, the efficient disposal of the acutely accumulated BACE1 solely depends on GGA3 levels in the subacute phase of injury

  3. GGA3 tightly and inversely regulate BACE1 levels via interaction with ubiquitin sorting machinery

Human Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 3 (GGA3) interaction partners

  1. SNPs: rs6414624 in EVC and rs78338345 in GGA3 are novel susceptibility loci for type 2 diabetes mellitus in Japanese individuals.

  2. In the absence of GGA3, integrins are increasingly retained inside the cell, traffic toward the perinuclear lysosomal compartment and their degradation is enhanced.

  3. This work identifies GGA3 as a key player in a novel DXXLL-mediated endosomal sorting machinery that targets TrkA to the plasma membrane, where it prolongs the activation of Akt signaling and survival responses.

  4. role of GGA3 in the cell surface export of alpha2B-adrenergic receptor

  5. These data indicate that clathrin is required for the function of AP-1- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane.

  6. GGA3 is involved in the cellular processes relevant for Alzheimer's disease pathogenesis.

  7. Subcellular fractionation of Alzheimer's disease cortex with low levels of Golgi-localized GGA proteins shows an alteration of beta-secretase distribution and extensive co-localization with amyloid beta precursor protein APP.

  8. GGA3 tightly and inversely regulate BACE1 levels via interaction with ubiquitin sorting machinery

  9. structures of the VHS domain of human GGA3 complexed with signals from both mannose-6-phosphate receptors

  10. These results indicate that GGA3-S is predominantly expressed in human tissues except the brain and in cell lines.

  11. RNAi of GGA3 expression results in accumulation of the cation-independent mannose 6-phosphate receptor and internalized epidermal growth factor (EGF) within enlarged early endosomes. This perturbation impairs the degradation of internalized EGF.

  12. found that the human GGA3 protein GAT domain contains two ubiquitin binding motifs that bind to the same surface of ubiquitin

  13. GGA proteins funstion with the phosphorylated ACDL in the memasin 2-recycling pathway from endosomes to trans Golgi on the way back to the cell surface.

  14. crystal structure of the GAT domain

  15. GGA3, becomes transiently phosphorylated upon activation of the epidermal growth factor (EGF) receptor. (GGA3)

  16. CK2-activated phosphorylation cascade controlling PACS-1- and GGA3-mediated CI-MPR sorting, is reported.

  17. ubiquitin binding and ubiquitylation of GGA3-GAT domain are mutually inseparable through a ubiquitin ligase activity of hVPS18

  18. These results show that the dual roles of PI4P can promote specific GGA targeting and cargo recognition at the trans-Golgi network.

  19. We have elucidated a GGA3-dependent mechanism regulating BACE levels and beta-secretase activity. This mechanism may explain increased cerebral levels of BACE and Abeta following cerebral ischemia and existing in AD.

  20. GGA overexpression causes various sorting defects as measured by recycling of CD-MPR, internalization of transferrin receptor, and the subcellular localization of proteins like Tsg101, ubiquitin, and Hrs.

GGA3 Protein Profile

Protein Summary

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants have been identified in this gene.

Gene names and symbols associated with GGA3

  • golgi associated, gamma adaptin ear containing, ARF binding protein 3 (Gga3)
  • golgi associated, gamma adaptin ear containing, ARF binding protein 3 (GGA3)
  • C230037M19Rik protein
  • mKIAA0154 protein

Protein level used designations for GGA3

ADP-ribosylation factor-binding protein GGA3 , golgi-localized, gamma ear-containing, ARF-binding protein 3 , Golgi-localized, gamma ear-containing, ARF-binding protein 3 , golgi associated, gamma adaptin ear containing, ARF binding protein 3 , ADP-ribosylation factor binding protein 3

GENE ID SPECIES
260302 Mus musculus
360658 Rattus norvegicus
23163 Homo sapiens
483310 Canis lupus familiaris
454877 Pan troglodytes
100172741 Pongo abelii
100525777 Sus scrofa
510539 Bos taurus
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