anti-Granulin (GRN) Antibodies

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif.

list all antibodies Gene Name GeneID UniProt
Anti-Human GRN GRN 2896 P28799
Anti-Rat GRN GRN 29143 P23785
Anti-Mouse GRN GRN 14824  
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Top anti-Granulin Antibodies at antibodies-online.com

Showing 10 out of 163 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: Granulin Antibody [NBP1-87324] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells).Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells) Immunocytochemistry/Immunofluorescence: Granulin Antibody [NBP1-87324] - Staining of human cell line A-431 shows positivity in vesicles. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Goat Un-conjugated ELISA, WB EB08934 (1µg/ml) staining of HeLa lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: Granulin Antibody [NBP1-32076] - Rat tissue extract (50 ug) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Granulins antibody diluted at 1:1000. Western Blot: Granulin Antibody [NBP1-32076] - Sample (30 ug of whole cell lysate) A: HepG2 7. 5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Log in to see 8 to 11 Days
$514.63
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Rat tissue extract (50 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Granulins antibody , diluted at 1:1000. WB Image Mouse tissue extract (50 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Granulins antibody , diluted at 1:1000. 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: Granulin Antibody [NBP1-87325] Staining of human cell line U-251 MG shows positivity in vesicles. Immunohistochemistry-Paraffin: Granulin Antibody [NBP1-87325] - Staining of human duodenum shows strong cytoplasmic positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Mouse Kidney lysate; Primary Ab: 2µg/ml Rabbit Anti-Mouse GRN Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) 100 μg Log in to see 13 to 16 Days
$360.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human esophageal carcinoma labeled with Anti PGRN/Granulin Polyclonal Antibody,Unconjugated (ABIN728668) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded human esophageal carcinoma labeled with Anti PGRN Granulin Polyclonal Antibody, unconjugated (ABIN728668) at 1:200 followed by incubation with conjugated secondary antibody and DAB staining. 100 μL Log in to see 3 to 7 Days
$318.45
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$610.50
Details
Hamster Goat Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$610.50
Details

Top referenced anti-Granulin Antibodies

  1. Human Polyclonal Granulin Primary Antibody for WB - ABIN1881391 : Bhandari, Bateman: Structure and chromosomal location of the human granulin gene. in Biochemical and biophysical research communications 1992 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal Granulin Primary Antibody for ELISA, WB - ABIN966227 : Lu, Serrero: Stimulation of PC cell-derived growth factor (epithelin/granulin precursor) expression by estradiol in human breast cancer cells. in Biochemical and biophysical research communications 1999 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal Granulin Primary Antibody for IP, IHC - ABIN1169394 : Ho, Ip, Cheung, Lee, Chan, Wong, Fan: Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. in Hepatology (Baltimore, Md.) 2008 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal Granulin Primary Antibody for IF (p), IHC (p) - ABIN728668 : Thurner, Fadle, Regitz, Kemele, Klemm, Zaks, Stöger, Bette, Carbon, Zimmer, Assmann, Murawski, Kubuschok, Held, Preuss, Pfreundschuh: The molecular basis for development of proinflammatory autoantibodies to progranulin. in Journal of autoimmunity 2015 (PubMed)

  5. Human Polyclonal Granulin Primary Antibody for ELISA, WB - ABIN439720 : Ghetti, Spina, Murrell, Huey, Pietrini, Sweeney, Wassermann, Keohane, Farlow, Grafman: In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17. in Neuro-degenerative diseases 2008 (PubMed)

  6. Human Polyclonal Granulin Primary Antibody for ELISA, WB - ABIN561132 : Bandey, Chiou, Huang, Tsai, Tu: Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness. in Oncogene 2015 (PubMed)

  7. Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315998 : Elkabets, Gifford, Scheel, Nilsson, Reinhardt, Bray, Carpenter, Jirström, Magnusson, Ebert, Pontén, Weinberg, McAllister: Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. in The Journal of clinical investigation 2011 (PubMed)

  8. Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315995 : Kahle, Gulbahce, Shaw, Lim, Hill, Barabási, Zoghbi: Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. in Human molecular genetics 2011 (PubMed)

More Antibodies against Granulin Interaction Partners

Zebrafish Granulin (GRN) interaction partners

  1. The data od this study suggest that Pgrn-a plays a dual role during nervous system development by governing the rate at which progenitors progress through the cell cycle and attracting microglial progenitors into the embryonic brain and retina.

  2. Findings show that miR (show MYLIP Antibodies)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (show MYLIP Antibodies)-145 in zebrafish embryonic development.

  3. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  4. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) interaction partners

  1. PGRN is a regulator of tumorigenesis because it stimulates cell proliferation, migration, invasion, angiogenesis, malignant transformation, resistance to anticancer drugs, and immune evasion. [review]

  2. PGRN regulated its own expression in a positive feedback loop via the AKT (show AKT1 Antibodies) and ERK (show EPHB2 Antibodies) signaling pathways.

  3. PGRN is involved in lysosomal homeostasis and lipid metabolism.

  4. High serum GP88 concentrations are associated with poor prognosis in patients with DLBCL

  5. This study showed that endogenous levels of multiple GRNs are haploinsufficient in FTD (show FTL Antibodies)-GRN patient fibroblasts and frontal cortex, mirroring full-length PGRN.

  6. HSPA5 (GRP78 (show HSPA5 Antibodies)) and GEP (show GNA12 Antibodies) were identified to interact. Clinical analysis showed that expression of GRP78 (show HSPA5 Antibodies) was up-regulated in hepatocellular carcinoma tumor and correlated with GEP (show GNA12 Antibodies) expression.

  7. the expression of PGRN was significantly upregulated in Osteonecrosis of the Femoral Head patients' articular cartilage, and recombinant PGRN could promote expression of aggrecan and collagen II and the activation of ERK1/2.

  8. White matter hyperintensities are seen only in GRN mutation carriers in fronto-temporal dementia.

  9. The study provides solid evidence that there is the interaction between GRN A and ENO1 and the interaction is responsible for the effects of GRN A on glucose uptake as well as cancer cell migration and invasion.

  10. This study ascertained that PGRN expression in airway epithelial cells inhibits CS-induced apoptosis, presumably through regulation of the ER stress response and MAPK (show MAPK1 Antibodies) activation.

Mouse (Murine) Granulin (GRN) interaction partners

  1. PGRN haploinsufficiency may decrease accumulation of Abeta (show APP Antibodies).

  2. that mutations resulting in progranulin is processed in the lysosome through the actions of cathepsins

  3. Results from conditional progranulin-knockout mice that lack progranulin in nestin (show NES Antibodies)-expressing cells (Nes (show NES Antibodies)-cKO mice), which include most neurons as well as astrocytes, suggest that increased lipofuscinosis and gliosis in Grn-null animals are not caused by intrinsic progranulin deficiency in neurons, and that microglia-derived progranulin may be sufficient to maintain neuronal health and homeostasis in the brain.

  4. PGRN deficiency exacerbates neuroinflammatory responses related to activated microglia in aged animals, while PGRN may not counteract the decline of hippocampal neurogenesis with age.

  5. PGRN is involved in lysosomal homeostasis and lipid metabolism.

  6. findings suggest that PGRN deficiency leads to excessive NF-kappaB (show NFKB1 Antibodies) activation in microglia and elevated TNFalpha (show TNF Antibodies) signaling, which in turn lead to hyperexcitability of medium spiny neurons and obsessive-compulsive behavior-like behavior.

  7. PGRN plays a protecting role in hippocampal neurogenesis.

  8. This study ascertained that PGRN expression in airway epithelial cells inhibits CS-induced apoptosis, presumably through regulation of the ER stress response and MAPK (show MAPK1 Antibodies) activation.

  9. This study demonstrated that Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice.

  10. The results of this study show that endogenous and recombinant PGRN limit axonal injury and astrogliosis and suggest therapeutic potential of PGRN in traumatic brain injury.

Guinea Pig Granulin (GRN) interaction partners

  1. ADAM15 (show ADAM15 Antibodies) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Granulin (GRN) Antigen Profile

Protein Summary

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Gene names and symbols associated with anti-Granulin (GRN) Antibodies

  • granulin precursor (GRN) antibody
  • granulin a (grna) antibody
  • Granulins (grn) antibody
  • granulin L homeolog (grn.L) antibody
  • granulin (granulin) antibody
  • granulin (ORF1 granulin) antibody
  • granulin precursor (Grn) antibody
  • granulin (Grn) antibody
  • acrogranin antibody
  • CLN11 antibody
  • DKFZp459H066 antibody
  • epithelin antibody
  • GEP antibody
  • GP88 antibody
  • grn antibody
  • MGC53354 antibody
  • PCDGF antibody
  • PEPI antibody
  • PGRN antibody
  • wu:fb11g12 antibody
  • wu:fj18f05 antibody

Protein level used designations for anti-Granulin (GRN) Antibodies

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPECIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
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