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Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Additionally we are shipping Granulin Kits (120) and Granulin Proteins (43) and many more products for this protein.
Showing 10 out of 161 products:
Human Polyclonal Granulin Primary Antibody for WB - ABIN1881391
Bhandari, Bateman: Structure and chromosomal location of the human granulin gene. in Biochemical and biophysical research communications 1992
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Human Monoclonal Granulin Primary Antibody for ELISA, WB - ABIN966227
Lu, Serrero: Stimulation of PC cell-derived growth factor (epithelin/granulin precursor) expression by estradiol in human breast cancer cells. in Biochemical and biophysical research communications 1999
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Human Monoclonal Granulin Primary Antibody for IP, IHC - ABIN1169394
Ho, Ip, Cheung, Lee, Chan, Wong, Fan: Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. in Hepatology (Baltimore, Md.) 2008
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Human Polyclonal Granulin Primary Antibody for ELISA, WB - ABIN561132
Bandey, Chiou, Huang, Tsai, Tu: Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness. in Oncogene 2015
Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315998
Elkabets, Gifford, Scheel, Nilsson, Reinhardt, Bray, Carpenter, Jirström, Magnusson, Ebert, Pontén, Weinberg, McAllister: Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. in The Journal of clinical investigation 2011
Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315995
Kahle, Gulbahce, Shaw, Lim, Hill, Barabási, Zoghbi: Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. in Human molecular genetics 2011
Human Polyclonal Granulin Primary Antibody for ELISA, WB - ABIN439720
Ghetti, Spina, Murrell, Huey, Pietrini, Sweeney, Wassermann, Keohane, Farlow, Grafman: In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17. in Neuro-degenerative diseases 2008
Human Polyclonal Granulin Primary Antibody for IF (p), IHC (p) - ABIN728668
Thurner, Fadle, Regitz, Kemele, Klemm, Zaks, Stöger, Bette, Carbon, Zimmer, Assmann, Murawski, Kubuschok, Held, Preuss, Pfreundschuh: The molecular basis for development of proinflammatory autoantibodies to progranulin. in Journal of autoimmunity 2015
Findings show that miR (show MYLIP Antibodies)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (show MYLIP Antibodies)-145 in zebrafish embryonic development.
the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes
GrnA positively modulates hepatic MET expression both in vivo and in vitro.
Our case report further corroborates the notion that, in addition to FTD (show FTL Antibodies), progranulin may be involved in the neurobiology of bipolar disorder type 1, and suggests to screen patients with late-onset bipolar disorder for GRN mutations.
GRN SNPs likely influence disease course and relapse recovery in multiple sclerosis.
This study revealed no patients presenting with typical clinical PSPS to have evidence of GRN mutations producing TDP-43 (show TARDBP Antibodies) pathology.
This study reported a novel pathogenic splice site mutation in GRN (c.709-2 A>T) causative for FTD (show FTL Antibodies) and we show that 1) GRN LoF mutations are a rare cause of FTD (show FTL Antibodies) in this Italian cohort.
progranulin expression is critical for tumor growth in vivo, in both xenograft and orthotopic tumor models
results revealed an important role of NF-kappaB (show NFKB1 Antibodies) signalling in PGRN-associated frontotemporal lobar degeneration-DNA-binding protein (show UBE2V1 Antibodies) 43 and confirm that PGRN can bind to TNF-alpha (show TNF Antibodies) receptors regulating the expression of WNT5A (show WNT5A Antibodies), suggesting novel targets for treatment of frontotemporal lobar degeneration-DNA-binding protein (show UBE2V1 Antibodies) linked to GRN mutations.
These results suggest an important role of Wnt (show WNT2 Antibodies) activation inducing cell cycle disturbance-mediated neuronal loss in the pathogenesis of PGRN deficiency-linked frontotemporal lobar degeneration with TDP-43 (show TARDBP Antibodies) protein inclusions.
Study demonstrate that PGRN interacts with the lysosomal protease CTSD (show CTSD Antibodies) and maintains its proper activity in vivo. Therefore, by regulating CTSD (show CTSD Antibodies) activity, PGRN may modulate protein homeostasis. This could potentially explain the TDP-43 (show TARDBP Antibodies) aggregation observed in frontotemporal lobar degeneration with GRN mutations.
Data indicate significant correlation of granulin-epithelin precursor (GEP (show GNA12 Antibodies)) with beta-catenin (show CTNNB1 Antibodies) in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cohort.
We identified 3 novel GRN mutations (p.Q130X, p.317Afs*12, and p.K259Afs*23) in patients diagnosed with nonfluent-variant PPA (show PPA1 Antibodies) or behavioral-variant FTD (show FTL Antibodies). The frequency of GRN mutations was 9.6% and that of MAPT (show MAPT Antibodies) mutations was 7.1%. Among familial cases of FTD (show FTL Antibodies), the frequency of GRN mutations was 31.5% and that of MAPT (show MAPT Antibodies) mutations was 10.5% in Brazil.
The results of this study show that endogenous and recombinant PGRN limit axonal injury and astrogliosis and suggest therapeutic potential of PGRN in traumatic brain injury.
Findings suggest that elevated PGRN is linked to cognitive deficits of fragile X (show FMR1 Antibodies) syndrome.
highlight an important role for neuron-derived progranulin in maintaining normal social function.
overexpression of PGRN was also found to increase activity of neprilysin (show MME Antibodies), a key amyloid beta degrading enzyme. PGRN regulation of neprilysin (show MME Antibodies) activity could play a major role in the observed alterations in plaque burden
PGRN decrease, resulting from pathogenic mutations, might compromise the trophism of cortical neurons by affecting GluN2B (show GRIN2B Antibodies)-contaning NMDA receptors
The PGRN is a nonredundant regulator of systemic inflammation via modulating the levels and activity of C/EBPalpha, IL-10, and the ubiquitin-proteasome proteolysis pathway.
Grn and Tmem106b genes have opposite effects on lysosomal enzyme levels, and their interaction determines the extent of neurodegeneration
PGRN induction of IL-10 (show IL10 Antibodies) in Treg cells depends on FOXO4 (show FOXO4 Antibodies) and Stat3 (show STAT3 Antibodies).
ADAM15 (show ADAM15 Antibodies) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
, PC cell-derived growth factor