anti-Granulin (GRN) Antibodies

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Additionally we are shipping Granulin Kits (130) and Granulin Proteins (45) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GRN 2896 P28799
GRN 29143 P23785
GRN 14824  
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Top anti-Granulin Antibodies at antibodies-online.com

Showing 10 out of 165 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated ELISA, WB EB08934 (1µg/ml) staining of HeLa lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$429.62
Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: Granulin Antibody [NBP1-87324] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells).Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells) Immunocytochemistry/Immunofluorescence: Granulin Antibody [NBP1-87324] - Staining of human cell line A-431 shows positivity in vesicles. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: Granulin Antibody [NBP1-32076] - Rat tissue extract (50 ug) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Granulins antibody diluted at 1:1000. Western Blot: Granulin Antibody [NBP1-32076] - Sample (30 ug of whole cell lysate) A: HepG2 7. 5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Log in to see 8 to 11 Days
$514.63
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Rat tissue extract (50 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Granulins antibody , diluted at 1:1000. WB Image Mouse tissue extract (50 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Granulins antibody , diluted at 1:1000. 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: Granulin Antibody [NBP1-87325] Staining of human cell line U-251 MG shows positivity in vesicles. Immunohistochemistry-Paraffin: Granulin Antibody [NBP1-87325] - Staining of human duodenum shows strong cytoplasmic positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Mouse Kidney lysate; Primary Ab: 2µg/ml Rabbit Anti-Mouse GRN Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) 100 μg Log in to see 13 to 16 Days
$360.00
Details
Human Mouse Un-conjugated ELISA, IF, WB Immunofluorescence of monoclonal antibody to GRN on HeLa cell (antibody concentration 10 µg/mL). GRN monoclonal antibody (M01), clone 1F5 Western Blot analysis of GRN expression in HeLa. 100 μg Log in to see 8 to 11 Days
$461.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human esophageal carcinoma labeled with Anti PGRN/Granulin Polyclonal Antibody,Unconjugated (ABIN728668) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Lane 1: mouse brain lysates Lane 2: human colon carcinoma lysates probed with Anti alpha Actinin PGRN/Granulin Polyclonal Antibody, Unconjugated (ABIN728668) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 63kD. Observed band size: 63kD. 100 μL Log in to see 3 to 7 Days
$318.45
Details
Hamster Goat Un-conjugated ELISA, WB 100 μg Log in to see 11 to 14 Days
$610.50
Details

Top referenced anti-Granulin Antibodies

  1. Human Polyclonal Granulin Primary Antibody for WB - ABIN1881391 : Bhandari, Bateman: Structure and chromosomal location of the human granulin gene. in Biochemical and biophysical research communications 1992 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal Granulin Primary Antibody for ELISA, WB - ABIN966227 : Lu, Serrero: Stimulation of PC cell-derived growth factor (epithelin/granulin precursor) expression by estradiol in human breast cancer cells. in Biochemical and biophysical research communications 1999 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal Granulin Primary Antibody for IP, IHC - ABIN1169394 : Ho, Ip, Cheung, Lee, Chan, Wong, Fan: Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. in Hepatology (Baltimore, Md.) 2008 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal Granulin Primary Antibody for ELISA, WB - ABIN439720 : Ghetti, Spina, Murrell, Huey, Pietrini, Sweeney, Wassermann, Keohane, Farlow, Grafman: In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17. in Neuro-degenerative diseases 2008 (PubMed)

  5. Human Polyclonal Granulin Primary Antibody for IF (p), IHC (p) - ABIN728668 : Thurner, Fadle, Regitz, Kemele, Klemm, Zaks, Stöger, Bette, Carbon, Zimmer, Assmann, Murawski, Kubuschok, Held, Preuss, Pfreundschuh: The molecular basis for development of proinflammatory autoantibodies to progranulin. in Journal of autoimmunity 2015 (PubMed)

  6. Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315995 : Kahle, Gulbahce, Shaw, Lim, Hill, Barabási, Zoghbi: Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. in Human molecular genetics 2011 (PubMed)

  7. Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315998 : Elkabets, Gifford, Scheel, Nilsson, Reinhardt, Bray, Carpenter, Jirström, Magnusson, Ebert, Pontén, Weinberg, McAllister: Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. in The Journal of clinical investigation 2011 (PubMed)

  8. Human Polyclonal Granulin Primary Antibody for ELISA, WB - ABIN561132 : Bandey, Chiou, Huang, Tsai, Tu: Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness. in Oncogene 2015 (PubMed)

More Antibodies against Granulin Interaction Partners

Zebrafish Granulin (GRN) interaction partners

  1. The data od this study suggest that Pgrn-a plays a dual role during nervous system development by governing the rate at which progenitors progress through the cell cycle and attracting microglial progenitors into the embryonic brain and retina.

  2. Findings show that miR (show MYLIP Antibodies)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (show MYLIP Antibodies)-145 in zebrafish embryonic development.

  3. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  4. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) interaction partners

  1. miR (show MLXIP Antibodies)-29b-3p bound to PGRN in a direct manner. Transfection with si-PGRN correlated with elevated E-cadherin (show CDH1 Antibodies) expression, decreased snail (show SNAI1 Antibodies) and vimentin (show VIM Antibodies) expressions, as well as less-motivated cell proliferation and cell metastasis. The H19 (show NCKAP1 Antibodies)/miR (show MLXIP Antibodies)-29b-3p/PGRN axis modulated epithelial-mesenchymal transition of NSCLC cells via Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling.

  2. SNPs in GRN are not related to ankylosing spondylitis susceptibility in a Chinese Han population.

  3. Plasma progranulin levels predict the presence of GRN null mutations independent of proximity to symptoms and brain atrophy.

  4. Serum progranulin may have potential to be used as a biomarker for the differentiation between early-onset pre-eclampsia and late-onset pre-eclampsia.

  5. CHI3L1 (show CHI3L1 Antibodies) may be a previously unrecognized biomarker for diagnosing Gaucher Diseases (GD) and for evaluating the therapeutic effects of new GD drug.

  6. The increased serum progranulin concentrations were closely related to measures of adiposity, metabolic parameters, inflammatory marker and insulin (show INS Antibodies) resistance indices, suggesting that progranulin may be an excellent biomarker for obesity in childhood.

  7. This work identifies PGRN as an activator of lysosomal cathepsin D (show CTSD Antibodies) activity, and suggests that decreased cathepsin D (show CTSD Antibodies) activity due to loss of PGRN contributes to both FTD (show FTL Antibodies) and NCL (show CLN5 Antibodies) pathology in a dose-dependent manner.

  8. MiR (show MLXIP Antibodies)-29b-3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN.

  9. Results provide evidence that progranulin destabilizes sortilin (show SORT1 Antibodies) via ubiquitination and lysosomal degradation to override the negative modulatory functions of sortilin (show SORT1 Antibodies) thereby assuring the sustainable pro-tumorigenic actions of progranulin in castration-resistant prostate cancer.

  10. PGRN is a regulator of tumorigenesis because it stimulates cell proliferation, migration, invasion, angiogenesis, malignant transformation, resistance to anticancer drugs, and immune evasion. [review]

Mouse (Murine) Granulin (GRN) interaction partners

  1. Progranulin deficiency decreased the number of microglia and retinal precursor cells.

  2. CHI3L1 (show CHI3L1 Antibodies) may be a previously unrecognized biomarker for diagnosing Gaucher Diseases (GD) and for evaluating the therapeutic effects of new GD drug.

  3. this study shows that C5a/C5aR pathway accelerates renal ischemia-reperfusion injury by downregulating PGRN expression

  4. PGRN reduction from knock-in R504X mutation disinhibits Gas6 (show GAS6 Antibodies) binding to Tyro3 (show TYRO3 Antibodies), resulting in activation of PKCalpha (show PKCa Antibodies) via PLCgamma, inducing tau phosphorylation at Ser203, mislocalization of tau to dendritic spines, and spine loss

  5. PGRN haploinsufficiency may decrease accumulation of Abeta (show APP Antibodies).

  6. that mutations resulting in progranulin is processed in the lysosome through the actions of cathepsins

  7. Results from conditional progranulin-knockout mice that lack progranulin in nestin (show NES Antibodies)-expressing cells (Nes (show NES Antibodies)-cKO mice), which include most neurons as well as astrocytes, suggest that increased lipofuscinosis and gliosis in Grn-null animals are not caused by intrinsic progranulin deficiency in neurons, and that microglia-derived progranulin may be sufficient to maintain neuronal health and homeostasis in the brain.

  8. PGRN deficiency exacerbates neuroinflammatory responses related to activated microglia in aged animals, while PGRN may not counteract the decline of hippocampal neurogenesis with age.

  9. PGRN is involved in lysosomal homeostasis and lipid metabolism.

  10. findings suggest that PGRN deficiency leads to excessive NF-kappaB (show NFKB1 Antibodies) activation in microglia and elevated TNFalpha (show TNF Antibodies) signaling, which in turn lead to hyperexcitability of medium spiny neurons and obsessive-compulsive behavior-like behavior.

Guinea Pig Granulin (GRN) interaction partners

  1. ADAM15 (show ADAM15 Antibodies) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Granulin (GRN) Antigen Profile

Protein Summary

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Gene names and symbols associated with anti-Granulin (GRN) Antibodies

  • granulin precursor (GRN) antibody
  • granulin a (grna) antibody
  • Granulins (grn) antibody
  • granulin L homeolog (grn.L) antibody
  • granulin (granulin) antibody
  • granulin (ORF1 granulin) antibody
  • granulin precursor (Grn) antibody
  • granulin (Grn) antibody
  • acrogranin antibody
  • CLN11 antibody
  • DKFZp459H066 antibody
  • epithelin antibody
  • GEP antibody
  • GP88 antibody
  • grn antibody
  • MGC53354 antibody
  • PCDGF antibody
  • PEPI antibody
  • PGRN antibody
  • wu:fb11g12 antibody
  • wu:fj18f05 antibody

Protein level used designations for anti-Granulin (GRN) Antibodies

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPECIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
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