anti-Granulin (GRN) Antibodies

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Additionally we are shipping Granulin Kits (120) and Granulin Proteins (43) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GRN 2896 P28799
GRN 29143 P23785
GRN 14824  
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Top anti-Granulin Antibodies at antibodies-online.com

Showing 10 out of 161 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human esophageal carcinoma labeled with Anti PGRN/Granulin Polyclonal Antibody,Unconjugated (ABIN728668) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded human esophageal carcinoma labeled with Anti PGRN Granulin Polyclonal Antibody, unconjugated (ABIN728668) at 1:200 followed by incubation with conjugated secondary antibody and DAB staining. 100 μL Log in to see 3 to 7 Days
$318.45
Details
Human Mouse Un-conjugated IP, IHC, ELISA, WB Immunoprecipitation of recombinant hProgranulin proteins using anti-Progranulin (human), mAb (PG359-7) . Recombinant hProgranulin Proteins were precipitated by PG359-7. The precipitated proteins were separated by SDS-PAGE, electroblotted, and visualized by Western blot/ECL reaction with rabbit anti-human Progranulin pAb. Western blot analysis using anti-Progranulin (human), mAb (PG359-7)  at 1:2,000 dilution. 1. Recombinant human Progranulin (FLAG ® -tagged). 2. Recombinant mouse Progranulin (FLAG ® -tagged) (Negative control). 3. Recombinant human GRN-C (FLAG ® -tagged). 4. Recombinant mouse Vaspin (FLAG ® -tagged) (Negative control). 100 μg Log in to see 5 to 8 Days
$362.25
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: Granulin Antibody [NBP1-32076] - Rat tissue extract (50 ug) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Granulins antibody diluted at 1:1000. Western Blot: Granulin Antibody [NBP1-32076] - Sample (30 ug of whole cell lysate) A: HepG2 7. 5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Log in to see 7 to 9 Days
$514.63
Details
Mouse Rabbit Un-conjugated ELISA, IHC (p) 100 μg Log in to see 20 to 21 Days
$218.90
Details
Human Rabbit Un-conjugated WB GRN Antibody (C-term) (ABIN1881391) western blot analysis in A2058,HepG2,HL-60,T47D cell line lysates (35 µg/lane). This demonstrates the GRN antibody detected the GRN protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 7 to 9 Days
$485.88
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Rat tissue extract (50 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Granulins antibody , diluted at 1:1000. WB Image Mouse tissue extract (50 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Granulins antibody , diluted at 1:1000. 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$481.25
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: Granulin Antibody [NBP1-87325] Staining of human cell line U-251 MG shows positivity in vesicles. Immunohistochemistry-Paraffin: Granulin Antibody [NBP1-87325] - Staining of human duodenum shows strong cytoplasmic positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details

GRN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Granulin Antibodies

  1. Human Polyclonal Granulin Primary Antibody for WB - ABIN1881391 : Bhandari, Bateman: Structure and chromosomal location of the human granulin gene. in Biochemical and biophysical research communications 1992 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal Granulin Primary Antibody for ELISA, WB - ABIN966227 : Lu, Serrero: Stimulation of PC cell-derived growth factor (epithelin/granulin precursor) expression by estradiol in human breast cancer cells. in Biochemical and biophysical research communications 1999 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal Granulin Primary Antibody for IP, IHC - ABIN1169394 : Ho, Ip, Cheung, Lee, Chan, Wong, Fan: Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. in Hepatology (Baltimore, Md.) 2008 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal Granulin Primary Antibody for ELISA, WB - ABIN561132 : Bandey, Chiou, Huang, Tsai, Tu: Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness. in Oncogene 2015 (PubMed)

  5. Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315998 : Elkabets, Gifford, Scheel, Nilsson, Reinhardt, Bray, Carpenter, Jirström, Magnusson, Ebert, Pontén, Weinberg, McAllister: Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. in The Journal of clinical investigation 2011 (PubMed)

  6. Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315995 : Kahle, Gulbahce, Shaw, Lim, Hill, Barabási, Zoghbi: Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. in Human molecular genetics 2011 (PubMed)

  7. Human Polyclonal Granulin Primary Antibody for ELISA, WB - ABIN439720 : Ghetti, Spina, Murrell, Huey, Pietrini, Sweeney, Wassermann, Keohane, Farlow, Grafman: In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17. in Neuro-degenerative diseases 2008 (PubMed)

  8. Human Polyclonal Granulin Primary Antibody for IF (p), IHC (p) - ABIN728668 : Thurner, Fadle, Regitz, Kemele, Klemm, Zaks, Stöger, Bette, Carbon, Zimmer, Assmann, Murawski, Kubuschok, Held, Preuss, Pfreundschuh: The molecular basis for development of proinflammatory autoantibodies to progranulin. in Journal of autoimmunity 2015 (PubMed)

More Antibodies against Granulin Interaction Partners

Zebrafish Granulin (GRN) interaction partners

  1. Findings show that miR (show MYLIP Antibodies)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (show MYLIP Antibodies)-145 in zebrafish embryonic development.

  2. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  3. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) interaction partners

  1. Our case report further corroborates the notion that, in addition to FTD (show FTL Antibodies), progranulin may be involved in the neurobiology of bipolar disorder type 1, and suggests to screen patients with late-onset bipolar disorder for GRN mutations.

  2. GRN SNPs likely influence disease course and relapse recovery in multiple sclerosis.

  3. This study revealed no patients presenting with typical clinical PSPS to have evidence of GRN mutations producing TDP-43 (show TARDBP Antibodies) pathology.

  4. This study reported a novel pathogenic splice site mutation in GRN (c.709-2 A>T) causative for FTD (show FTL Antibodies) and we show that 1) GRN LoF mutations are a rare cause of FTD (show FTL Antibodies) in this Italian cohort.

  5. progranulin expression is critical for tumor growth in vivo, in both xenograft and orthotopic tumor models

  6. results revealed an important role of NF-kappaB (show NFKB1 Antibodies) signalling in PGRN-associated frontotemporal lobar degeneration-DNA-binding protein (show UBE2V1 Antibodies) 43 and confirm that PGRN can bind to TNF-alpha (show TNF Antibodies) receptors regulating the expression of WNT5A (show WNT5A Antibodies), suggesting novel targets for treatment of frontotemporal lobar degeneration-DNA-binding protein (show UBE2V1 Antibodies) linked to GRN mutations.

  7. These results suggest an important role of Wnt (show WNT2 Antibodies) activation inducing cell cycle disturbance-mediated neuronal loss in the pathogenesis of PGRN deficiency-linked frontotemporal lobar degeneration with TDP-43 (show TARDBP Antibodies) protein inclusions.

  8. Study demonstrate that PGRN interacts with the lysosomal protease CTSD (show CTSD Antibodies) and maintains its proper activity in vivo. Therefore, by regulating CTSD (show CTSD Antibodies) activity, PGRN may modulate protein homeostasis. This could potentially explain the TDP-43 (show TARDBP Antibodies) aggregation observed in frontotemporal lobar degeneration with GRN mutations.

  9. Data indicate significant correlation of granulin-epithelin precursor (GEP (show GNA12 Antibodies)) with beta-catenin (show CTNNB1 Antibodies) in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cohort.

  10. We identified 3 novel GRN mutations (p.Q130X, p.317Afs*12, and p.K259Afs*23) in patients diagnosed with nonfluent-variant PPA (show PPA1 Antibodies) or behavioral-variant FTD (show FTL Antibodies). The frequency of GRN mutations was 9.6% and that of MAPT (show MAPT Antibodies) mutations was 7.1%. Among familial cases of FTD (show FTL Antibodies), the frequency of GRN mutations was 31.5% and that of MAPT (show MAPT Antibodies) mutations was 10.5% in Brazil.

Mouse (Murine) Granulin (GRN) interaction partners

  1. The results of this study show that endogenous and recombinant PGRN limit axonal injury and astrogliosis and suggest therapeutic potential of PGRN in traumatic brain injury.

  2. progranulin expression is critical for tumor growth in vivo, in both xenograft and orthotopic tumor models

  3. Study demonstrate that PGRN interacts with the lysosomal protease CTSD (show CTSD Antibodies) and maintains its proper activity in vivo. Therefore, by regulating CTSD (show CTSD Antibodies) activity, PGRN may modulate protein homeostasis. This could potentially explain the TDP-43 (show TARDBP Antibodies) aggregation observed in frontotemporal lobar degeneration with GRN mutations.

  4. Findings suggest that elevated PGRN is linked to cognitive deficits of fragile X (show FMR1 Antibodies) syndrome.

  5. highlight an important role for neuron-derived progranulin in maintaining normal social function.

  6. overexpression of PGRN was also found to increase activity of neprilysin (show MME Antibodies), a key amyloid beta degrading enzyme. PGRN regulation of neprilysin (show MME Antibodies) activity could play a major role in the observed alterations in plaque burden

  7. PGRN decrease, resulting from pathogenic mutations, might compromise the trophism of cortical neurons by affecting GluN2B (show GRIN2B Antibodies)-contaning NMDA receptors

  8. The PGRN is a nonredundant regulator of systemic inflammation via modulating the levels and activity of C/EBPalpha, IL-10, and the ubiquitin-proteasome proteolysis pathway.

  9. Grn and Tmem106b genes have opposite effects on lysosomal enzyme levels, and their interaction determines the extent of neurodegeneration

  10. PGRN induction of IL-10 (show IL10 Antibodies) in Treg cells depends on FOXO4 (show FOXO4 Antibodies) and Stat3 (show STAT3 Antibodies).

Guinea Pig Granulin (GRN) interaction partners

  1. ADAM15 (show ADAM15 Antibodies) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Granulin (GRN) Antigen Profile

Protein Summary

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Gene names and symbols associated with anti-Granulin (GRN) Antibodies

  • granulin precursor (GRN) antibody
  • granulin a (grna) antibody
  • Granulins (grn) antibody
  • granulin L homeolog (grn.L) antibody
  • granulin (granulin) antibody
  • granulin (ORF1 granulin) antibody
  • granulin precursor (Grn) antibody
  • granulin (Grn) antibody
  • acrogranin antibody
  • CLN11 antibody
  • DKFZp459H066 antibody
  • epithelin antibody
  • GEP antibody
  • GP88 antibody
  • grn antibody
  • MGC53354 antibody
  • PCDGF antibody
  • PEPI antibody
  • PGRN antibody
  • wu:fb11g12 antibody
  • wu:fj18f05 antibody

Protein level used designations for anti-Granulin (GRN) Antibodies

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPECIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
Selected quality suppliers for anti-Granulin (GRN) Antibodies
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