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Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Additionally we are shipping Granulin Kits (119) and Granulin Proteins (43) and many more products for this protein.
Showing 10 out of 164 products:
Human Polyclonal Granulin Primary Antibody for WB - ABIN1881391
Bhandari, Bateman: Structure and chromosomal location of the human granulin gene. in Biochemical and biophysical research communications 1992
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Human Monoclonal Granulin Primary Antibody for IP, IHC - ABIN1169394
Ho, Ip, Cheung, Lee, Chan, Wong, Fan: Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. in Hepatology (Baltimore, Md.) 2008
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Human Monoclonal Granulin Primary Antibody for ELISA, WB - ABIN966227
Lu, Serrero: Stimulation of PC cell-derived growth factor (epithelin/granulin precursor) expression by estradiol in human breast cancer cells. in Biochemical and biophysical research communications 1999
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Human Polyclonal Granulin Primary Antibody for IF (p), IHC (p) - ABIN728668
Thurner, Fadle, Regitz, Kemele, Klemm, Zaks, Stöger, Bette, Carbon, Zimmer, Assmann, Murawski, Kubuschok, Held, Preuss, Pfreundschuh: The molecular basis for development of proinflammatory autoantibodies to progranulin. in Journal of autoimmunity 2015
Human Polyclonal Granulin Primary Antibody for ELISA, WB - ABIN439720
Ghetti, Spina, Murrell, Huey, Pietrini, Sweeney, Wassermann, Keohane, Farlow, Grafman: In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17. in Neuro-degenerative diseases 2008
Human Polyclonal Granulin Primary Antibody for ELISA, WB - ABIN561132
Bandey, Chiou, Huang, Tsai, Tu: Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness. in Oncogene 2015
Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315998
Elkabets, Gifford, Scheel, Nilsson, Reinhardt, Bray, Carpenter, Jirström, Magnusson, Ebert, Pontén, Weinberg, McAllister: Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. in The Journal of clinical investigation 2011
Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315995
Kahle, Gulbahce, Shaw, Lim, Hill, Barabási, Zoghbi: Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. in Human molecular genetics 2011
Findings show that miR (show MYLIP Antibodies)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (show MYLIP Antibodies)-145 in zebrafish embryonic development.
the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes
GrnA positively modulates hepatic MET expression both in vivo and in vitro.
HSPA5 (GRP78 (show HSPA5 Antibodies)) and GEP (show GNA12 Antibodies) were identified to interact. Clinical analysis showed that expression of GRP78 (show HSPA5 Antibodies) was up-regulated in hepatocellular carcinoma tumor and correlated with GEP (show GNA12 Antibodies) expression.
the expression of PGRN was significantly upregulated in Osteonecrosis of the Femoral Head patients' articular cartilage, and recombinant PGRN could promote expression of aggrecan and collagen II and the activation of ERK1/2.
White matter hyperintensities are seen only in GRN mutation carriers in fronto-temporal dementia.
The study provides solid evidence that there is the interaction between GRN A and ENO1 and the interaction is responsible for the effects of GRN A on glucose uptake as well as cancer cell migration and invasion.
This study ascertained that PGRN expression in airway epithelial cells inhibits CS-induced apoptosis, presumably through regulation of the ER stress response and MAPK (show MAPK1 Antibodies) activation.
mTOR (show FRAP1 Antibodies) signaling contributes to PGRN-stimulated carcinogenesis of cervical cancer
This study describe a novel GRN, p.(Tyr229*) mutation, resulting in haploinsufficiency of GRN and a severe neuropathologic FTLD phenotype.
This meta-analysis supported the T allele of rs5848 within progranulin, as a risk factor for Alzheimer's Disease.
Our case report further corroborates the notion that, in addition to FTD (show FTL Antibodies), progranulin may be involved in the neurobiology of bipolar disorder type 1, and suggests to screen patients with late-onset bipolar disorder for GRN mutations.
GRN SNPs likely influence disease course and relapse recovery in multiple sclerosis.
PGRN plays a protecting role in hippocampal neurogenesis.
This study demonstrated that Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice.
The results of this study show that endogenous and recombinant PGRN limit axonal injury and astrogliosis and suggest therapeutic potential of PGRN in traumatic brain injury.
progranulin expression is critical for tumor growth in vivo, in both xenograft and orthotopic tumor models
Study demonstrate that PGRN interacts with the lysosomal protease CTSD (show CTSD Antibodies) and maintains its proper activity in vivo. Therefore, by regulating CTSD (show CTSD Antibodies) activity, PGRN may modulate protein homeostasis. This could potentially explain the TDP-43 (show TARDBP Antibodies) aggregation observed in frontotemporal lobar degeneration with GRN mutations.
Findings suggest that elevated PGRN is linked to cognitive deficits of fragile X (show FMR1 Antibodies) syndrome.
highlight an important role for neuron-derived progranulin in maintaining normal social function.
overexpression of PGRN was also found to increase activity of neprilysin (show MME Antibodies), a key amyloid beta degrading enzyme. PGRN regulation of neprilysin (show MME Antibodies) activity could play a major role in the observed alterations in plaque burden
PGRN decrease, resulting from pathogenic mutations, might compromise the trophism of cortical neurons by affecting GluN2B (show GRIN2B Antibodies)-contaning NMDA receptors
ADAM15 (show ADAM15 Antibodies) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
, PC cell-derived growth factor