anti-Granulin (GRN) Antibodies

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Additionally we are shipping Granulin Proteins (44) and Granulin Kits (37) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GRN 2896 P28799
GRN 29143 P23785
GRN 14824  
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Top anti-Granulin Antibodies at antibodies-online.com

Showing 10 out of 165 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Goat Un-conjugated ELISA, WB EB08934 (1µg/ml) staining of HeLa lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
$429.84
Details
Cow Rabbit Un-conjugated IHC, WB 100 μL 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Rat tissue extract (50 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Granulins antibody , diluted at 1:1000. WB Image Mouse tissue extract (50 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Granulins antibody , diluted at 1:1000. 100 μL 3 to 4 Days
$466.18
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Mouse Kidney lysate; Primary Ab: 2µg/ml Rabbit Anti-Mouse GRN Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) 100 μg 13 to 16 Days
$360.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human esophageal carcinoma labeled with Anti PGRN/Granulin Polyclonal Antibody,Unconjugated (ABIN728668) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Lane 1: mouse brain lysates Lane 2: human colon carcinoma lysates probed with Anti alpha Actinin PGRN/Granulin Polyclonal Antibody, Unconjugated (ABIN728668) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 63kD. Observed band size: 63kD. 100 μL 3 to 7 Days
$329.45
Details
Human Goat Un-conjugated ELISA, WB 100 μg 11 to 14 Days
$610.50
Details
Hamster Goat Un-conjugated ELISA, WB 100 μg 11 to 14 Days
$610.50
Details
Human Rabbit Un-conjugated IHC, IHC (p), IP, WB Human Uterus (formalin-fixed, paraffin-embedded) stained with GRN antibody ABIN396952 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-GRN / Granulin antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11 to 14 Days
$727.83
Details
Human Mouse Un-conjugated ELISA, ELISA (Detection), IF, IF/ICC 100 μL 14 to 16 Days
$247.82
Details
Mouse Rabbit Un-conjugated ELISA, IHC (p) 100 μL 14 to 16 Days
$247.82
Details

Top referenced anti-Granulin Antibodies

  1. Human Monoclonal Granulin Primary Antibody for ELISA, WB - ABIN966227 : Lu, Serrero: Stimulation of PC cell-derived growth factor (epithelin/granulin precursor) expression by estradiol in human breast cancer cells. in Biochemical and biophysical research communications 1999 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal Granulin Primary Antibody for IP, IHC - ABIN1169394 : Ho, Ip, Cheung, Lee, Chan, Wong, Fan: Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. in Hepatology (Baltimore, Md.) 2008 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315997 : Elkabets, Gifford, Scheel, Nilsson, Reinhardt, Bray, Carpenter, Jirström, Magnusson, Ebert, Pontén, Weinberg, McAllister: Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. in The Journal of clinical investigation 2011 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal Granulin Primary Antibody for ELISA, WB - ABIN541132 : Ghetti, Spina, Murrell, Huey, Pietrini, Sweeney, Wassermann, Keohane, Farlow, Grafman: In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17. in Neuro-degenerative diseases 2008 (PubMed)

  5. Human Polyclonal Granulin Primary Antibody for ELISA, WB - ABIN561132 : Bandey, Chiou, Huang, Tsai, Tu: Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness. in Oncogene 2015 (PubMed)

  6. Human Polyclonal Granulin Primary Antibody for IF (p), IHC (p) - ABIN728668 : Thurner, Fadle, Regitz, Kemele, Klemm, Zaks, Stöger, Bette, Carbon, Zimmer, Assmann, Murawski, Kubuschok, Held, Preuss, Pfreundschuh: The molecular basis for development of proinflammatory autoantibodies to progranulin. in Journal of autoimmunity 2015 (PubMed)

  7. Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315995 : Kahle, Gulbahce, Shaw, Lim, Hill, Barabási, Zoghbi: Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. in Human molecular genetics 2011 (PubMed)

More Antibodies against Granulin Interaction Partners

Zebrafish Granulin (GRN) interaction partners

  1. The data od this study suggest that Pgrn-a plays a dual role during nervous system development by governing the rate at which progenitors progress through the cell cycle and attracting microglial progenitors into the embryonic brain and retina.

  2. Findings show that miR-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR-145 in zebrafish embryonic development.

  3. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  4. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) interaction partners

  1. Its nonsense mutation causes tau astrogliopathy in frontotemporal dementia.

  2. frontotemporal lobar degeneration-associated GRN mutations W7R and A9D disrupt co-translational interaction with a targeting factor, signal recognition particle.

  3. These results suggest a strong association of psychotic symptoms with gray matter atrophy in the anterior insula in GRN mutation carriers.

  4. Genetic variation within GRN is associated with aging phenotypes.

  5. In conclusion, the authors demonstrate that, although cerebrospinal fluid progranulin is not a diagnostic biomarker for Alzheimer's disease, it may together with sTREM2 reflect microglial activation during the disease.

  6. Study shows that retrograde signaling from progranulin to sort1 counteracts synapse elimination in the developing cerebellum.

  7. The grn mutation of Frontotemporal Dementia have the atrophy in presubiculum and subiculum.

  8. GRN p.T487I mutation could be a new causative mutation in patients with atypical parkinsonism.

  9. GEP might serve as a useful prognostic biomarker and therapeutic target for colorectal cancer.

  10. rhPGRN exhibited significant inhibitory effect on the expression of TNF-alpha and the number of TRAP-positive cells. Human PGRN promotes regeneration of inflammatory periodontal bone defect in rats via anti-inflammation, osteoclastogenic inhibition, and osteogenic promotion.

  11. From these experiments, we gained no evidence for inhibitory effects of high concentrations (20-500 nM) of PGRN on the interaction of TNF with TNFR1 and TNFR2.

  12. Study present novel data that demonstrate how secretion of progranulin induce expansion of cancer stem cells (CSC) as well as converts differentiated sortilin-positive cells into a CSC-like state, rendering them more aggressive and metastatic independently of ERalpha status.

  13. Our results suggest that decreased PGRN expression may contribute to the frequent occurrence of skin infections, but not progression, in patients with MF.

  14. The elevated progranulin levels are associated with obesity in infertile women.

  15. The combined CLU/PGRN serum level may be used as a potential serological marker for identifying patients with toluene diisocyanate (TDI)-induced occupational asthma among TDI-exposed workers.

  16. PGRN overproduction due to constitutively activated c-Abl/PKC-delta/Fli1 pathway may contribute to the resistance of localized scleroderma dermal fibroblasts to the anti-fibrotic effect of TNF-alpha, which may be involved in maintaining their pro-fibrotic phenotype under the pro-inflammatory condition, as is the case with systemic scleroderma.

  17. Task-based fMRI is highly sensitive to early GRN-related neurodegenerative changes even in conditions in which no behavioral differences were observed. Prefrontal activation may have utility as a biomarker for Predementia in GRN mutation.

  18. structural gray matter and white matter changes in presymptomatic progranulin mutation carriers

  19. C-peptide is increased in sporadic and GRN-mutated Frontotemporal lobar degeneration (FTLD) patients; resistin, an adipokine involved in inflammatory-related diseases, is specifically increased in FTLD due to GRN null mutations; ghrelin concentration is specifically increased in pre-symptomatic subjects and FTLD patients with GRN mutations.

  20. Taken together, we hypothesize that PGRN A9D leads to the retention of ANG in the cytoplasm to protect cells from PGRN A9D-induced apoptosis, implying that PGRN and ANG act in concert to regulate the progress of neurodegenerative disease.

Mouse (Murine) Granulin (GRN) interaction partners

  1. These studies not only provide new insights into the pathogenesis of Tay-Sachs Disease but may also have implications for developing PGRN-based therapy for this life-threatening disorder. Recombinant PGRN significantly reduces GM2 accumulation and lysosomal storage both in vivo and in vitro, which works through increasing the expression and lysosomal delivery of HexA.

  2. Progranulin (PGRN) is significantly induced in response to Streptococcus pneumoniae (S.pn) during acute otitis media (AOM).

  3. Study shows that retrograde signaling from progranulin to sort1 counteracts synapse elimination in the developing cerebellum.

  4. Accumulating evidence suggests that PGRN is essential for proper lysosomal function, but the precise mechanisms involved are not known. Here, we show that PGRN facilitates neuronal uptake and lysosomal delivery of prosaposin (PSAP), the precursor of saposin peptides that are essential for lysosomal glycosphingolipid degradation.

  5. Progranulin deficiency decreased the number of microglia and retinal precursor cells.

  6. CHI3L1 may be a previously unrecognized biomarker for diagnosing Gaucher Diseases (GD) and for evaluating the therapeutic effects of new GD drug.

  7. this study shows that C5a/C5aR pathway accelerates renal ischemia-reperfusion injury by downregulating PGRN expression

  8. PGRN reduction from knock-in R504X mutation disinhibits Gas6 binding to Tyro3, resulting in activation of PKCalpha via PLCgamma, inducing tau phosphorylation at Ser203, mislocalization of tau to dendritic spines, and spine loss

  9. PGRN haploinsufficiency may decrease accumulation of Abeta.

  10. that mutations resulting in progranulin is processed in the lysosome through the actions of cathepsins

  11. Results from conditional progranulin-knockout mice that lack progranulin in nestin-expressing cells (Nes-cKO mice), which include most neurons as well as astrocytes, suggest that increased lipofuscinosis and gliosis in Grn-null animals are not caused by intrinsic progranulin deficiency in neurons, and that microglia-derived progranulin may be sufficient to maintain neuronal health and homeostasis in the brain.

  12. PGRN deficiency exacerbates neuroinflammatory responses related to activated microglia in aged animals, while PGRN may not counteract the decline of hippocampal neurogenesis with age.

  13. PGRN is involved in lysosomal homeostasis and lipid metabolism.

  14. findings suggest that PGRN deficiency leads to excessive NF-kappaB activation in microglia and elevated TNFalpha signaling, which in turn lead to hyperexcitability of medium spiny neurons and obsessive-compulsive behavior-like behavior.

  15. PGRN plays a protecting role in hippocampal neurogenesis.

  16. This study ascertained that PGRN expression in airway epithelial cells inhibits CS-induced apoptosis, presumably through regulation of the ER stress response and MAPK activation.

  17. This study demonstrated that Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice.

  18. The results of this study show that endogenous and recombinant PGRN limit axonal injury and astrogliosis and suggest therapeutic potential of PGRN in traumatic brain injury.

  19. progranulin expression is critical for tumor growth in vivo, in both xenograft and orthotopic tumor models

  20. Study demonstrate that PGRN interacts with the lysosomal protease CTSD and maintains its proper activity in vivo. Therefore, by regulating CTSD activity, PGRN may modulate protein homeostasis. This could potentially explain the TDP-43 aggregation observed in frontotemporal lobar degeneration with GRN mutations.

Guinea Pig Granulin (GRN) interaction partners

  1. ADAM15 and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Granulin (GRN) Antigen Profile

Protein Summary

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Gene names and symbols associated with anti-Granulin (GRN) Antibodies

  • granulin precursor (GRN) antibody
  • granulin a (grna) antibody
  • Granulins (grn) antibody
  • granulin L homeolog (grn.L) antibody
  • granulin (granulin) antibody
  • granulin (ORF1 granulin) antibody
  • granulin precursor (Grn) antibody
  • granulin (Grn) antibody
  • acrogranin antibody
  • CLN11 antibody
  • DKFZp459H066 antibody
  • epithelin antibody
  • GEP antibody
  • GP88 antibody
  • grn antibody
  • MGC53354 antibody
  • PCDGF antibody
  • PEPI antibody
  • PGRN antibody
  • wu:fb11g12 antibody
  • wu:fj18f05 antibody

Protein level used designations for anti-Granulin (GRN) Antibodies

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPECIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
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