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Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Additionally we are shipping Granulin Kits (128) and Granulin Proteins (45) and many more products for this protein.
Showing 10 out of 165 products:
Human Polyclonal Granulin Primary Antibody for WB - ABIN1881391
Bhandari, Bateman: Structure and chromosomal location of the human granulin gene. in Biochemical and biophysical research communications 1992
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Human Monoclonal Granulin Primary Antibody for ELISA, WB - ABIN966227
Lu, Serrero: Stimulation of PC cell-derived growth factor (epithelin/granulin precursor) expression by estradiol in human breast cancer cells. in Biochemical and biophysical research communications 1999
Show all 2 Pubmed References
Human Monoclonal Granulin Primary Antibody for IP, IHC - ABIN1169394
Ho, Ip, Cheung, Lee, Chan, Wong, Fan: Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. in Hepatology (Baltimore, Md.) 2008
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Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315998
Elkabets, Gifford, Scheel, Nilsson, Reinhardt, Bray, Carpenter, Jirström, Magnusson, Ebert, Pontén, Weinberg, McAllister: Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. in The Journal of clinical investigation 2011
Human Polyclonal Granulin Primary Antibody for ELISA, WB - ABIN561132
Bandey, Chiou, Huang, Tsai, Tu: Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness. in Oncogene 2015
Human Polyclonal Granulin Primary Antibody for IF (p), IHC (p) - ABIN728668
Thurner, Fadle, Regitz, Kemele, Klemm, Zaks, Stöger, Bette, Carbon, Zimmer, Assmann, Murawski, Kubuschok, Held, Preuss, Pfreundschuh: The molecular basis for development of proinflammatory autoantibodies to progranulin. in Journal of autoimmunity 2015
Human Polyclonal Granulin Primary Antibody for ELISA, WB - ABIN439720
Ghetti, Spina, Murrell, Huey, Pietrini, Sweeney, Wassermann, Keohane, Farlow, Grafman: In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17. in Neuro-degenerative diseases 2008
Human Polyclonal Granulin Primary Antibody for ICC, IF - ABIN4315995
Kahle, Gulbahce, Shaw, Lim, Hill, Barabási, Zoghbi: Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. in Human molecular genetics 2011
The data od this study suggest that Pgrn-a plays a dual role during nervous system development by governing the rate at which progenitors progress through the cell cycle and attracting microglial progenitors into the embryonic brain and retina.
Findings show that miR (show MYLIP Antibodies)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (show MYLIP Antibodies)-145 in zebrafish embryonic development.
the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes
GrnA positively modulates hepatic MET expression both in vivo and in vitro.
CHI3L1 (show CHI3L1 Antibodies) may be a previously unrecognized biomarker for diagnosing Gaucher Diseases (GD) and for evaluating the therapeutic effects of new GD drug.
The increased serum progranulin concentrations were closely related to measures of adiposity, metabolic parameters, inflammatory marker and insulin (show INS Antibodies) resistance indices, suggesting that progranulin may be an excellent biomarker for obesity in childhood.
This work identifies PGRN as an activator of lysosomal cathepsin D (show CTSD Antibodies) activity, and suggests that decreased cathepsin D (show CTSD Antibodies) activity due to loss of PGRN contributes to both FTD (show FTL Antibodies) and NCL (show CLN5 Antibodies) pathology in a dose-dependent manner.
MiR (show MLXIP Antibodies)-29b-3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN.
Results provide evidence that progranulin destabilizes sortilin (show SORT1 Antibodies) via ubiquitination and lysosomal degradation to override the negative modulatory functions of sortilin (show SORT1 Antibodies) thereby assuring the sustainable pro-tumorigenic actions of progranulin in castration-resistant prostate cancer.
PGRN is a regulator of tumorigenesis because it stimulates cell proliferation, migration, invasion, angiogenesis, malignant transformation, resistance to anticancer drugs, and immune evasion. [review]
PGRN regulated its own expression in a positive feedback loop via the AKT (show AKT1 Antibodies) and ERK (show EPHB2 Antibodies) signaling pathways.
PGRN is involved in lysosomal homeostasis and lipid metabolism.
High serum GP88 concentrations are associated with poor prognosis in patients with DLBCL
This study showed that endogenous levels of multiple GRNs are haploinsufficient in FTD (show FTL Antibodies)-GRN patient fibroblasts and frontal cortex, mirroring full-length PGRN.
this study shows that C5a/C5aR pathway accelerates renal ischemia-reperfusion injury by downregulating PGRN expression
PGRN reduction from knock-in R504X mutation disinhibits Gas6 (show GAS6 Antibodies) binding to Tyro3 (show TYRO3 Antibodies), resulting in activation of PKCalpha (show PKCa Antibodies) via PLCgamma, inducing tau phosphorylation at Ser203, mislocalization of tau to dendritic spines, and spine loss
PGRN haploinsufficiency may decrease accumulation of Abeta (show APP Antibodies).
that mutations resulting in progranulin is processed in the lysosome through the actions of cathepsins
Results from conditional progranulin-knockout mice that lack progranulin in nestin (show NES Antibodies)-expressing cells (Nes (show NES Antibodies)-cKO mice), which include most neurons as well as astrocytes, suggest that increased lipofuscinosis and gliosis in Grn-null animals are not caused by intrinsic progranulin deficiency in neurons, and that microglia-derived progranulin may be sufficient to maintain neuronal health and homeostasis in the brain.
PGRN deficiency exacerbates neuroinflammatory responses related to activated microglia in aged animals, while PGRN may not counteract the decline of hippocampal neurogenesis with age.
findings suggest that PGRN deficiency leads to excessive NF-kappaB (show NFKB1 Antibodies) activation in microglia and elevated TNFalpha (show TNF Antibodies) signaling, which in turn lead to hyperexcitability of medium spiny neurons and obsessive-compulsive behavior-like behavior.
PGRN plays a protecting role in hippocampal neurogenesis.
ADAM15 (show ADAM15 Antibodies) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
, PC cell-derived growth factor