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The protein encoded by GDF5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. Additionally we are shipping GDF5 Kits (64) and GDF5 Proteins (42) and many more products for this protein.
Showing 10 out of 151 products:
Human Polyclonal GDF5 Primary Antibody for IHC (p), WB - ABIN388820
Liu, Lin, Sytwu, Chang: GDF-5 is suppressed by IL-1beta and enhances TGF-beta3-mediated chondrogenic differentiation in human rheumatoid fibroblast-like synoviocytes. in Experimental and molecular pathology 2010
Show all 4 Pubmed References
Changes in the expression of downstream regulators of skeletal differentiation, like barx1 (show BARX1 Antibodies) and gdf5, is one mechanism by which head skeletal element number and articulation are altered during evolution.
Results suggest that CDMP1/GDF5 requires cleavage by two distinct proteolytic enzymes.
Two Pakistani families with sequence variants in GDF5 and TRPS1 causing brachydactyly type C and tricho-rhino-phalangeal syndrome type III are described.
The dysfunctional gene GDF5 was successfully corrected in adipose tissue-derived mesenchymal stem cells using a pair of transcription activatorlike effector nucleases.
No association has been found between GDF5 +104 T/C promoter polymorphism and osteoarthritis in the Eastern Turkey population.
The results of the current study revealed that SNP rs143383 of GDF5 is a compelling risk factor for knee OA [Osteoarthritis] and that GDF5 has an etiological effect on the development of OA [Osteoarthritis].
A Study of IL-1beta, MMP-3, TGF-beta1, and GDF5 Polymorphisms and Their Association with Primary Frozen Shoulder in a Chinese Han Population
BMP-14 rs143383 polymorphism reduced the susceptibility to knee osteoarthritis (OA) and hand OA not only in total analysis but also in subgroup analysis; BMP-14 rs143383 polymorphism may be a protective factor against OA occurrence
The structure of Grem2 (show GREM2 Antibodies)-GDF5 complex has revealed a number of key findings for DAN-family mediated BMP2 (show BMP2 Antibodies) inhibition.
miR (show MLXIP Antibodies)-615-3p negatively regulates the osteogenic differentiation of hLF (show EPAS1 Antibodies) cells through post-transcriptionally suppressing osteogenic regulators GDF5 and FOXO1 (show FOXO1 Antibodies).
p38 (show CRK Antibodies), c-jun (show JUN Antibodies), and NFkappaB (show NFKB1 Antibodies) pathways activated during intervertebral disc degeneration by IL-1beta (show IL1B Antibodies) but not GDF-5
GDF5 elicited significant (p < 0.05) changes in the expression of anabolic, catabolic and hypertrophic genes with several consistent effects in healthy donors and in OA patients
Microarray analysis of satellite cells showed that expression of growth differentiation factor 5 (Gdf5) mRNA was markedly increased in Dnmt3a (show DNMT3A Antibodies)-KO mice. The DNA methylation (show HELLS Antibodies) level of the Gdf5 promoter was markedly decreased in Dnmt3a (show DNMT3A Antibodies)-KO satellite cells.
Study concludes that growth/differentiation factor-5 (GDF-5) protects hippocampal neurons against kainic acid-induced neurodegeneration by signaling through bone morphogenetic protein receptor type IB (show BMPR1B Antibodies), suggesting a therapeutic potential for GDF-5 in neurodegenerative diseases.
spatiotemporal dynamics of Gdf5 expression may instruct lineage divergence.
he large array of modular enhancers for Gdf5 provide a new foundation for studying the spatial specificity of joint patterning in vertebrates, as well as new candidates for regulatory regions that may also influence osteoarthritis risk in human population
Mutant GDF5 enhances ameloblast differentiation via accelerated BMP2 (show BMP2 Antibodies)-induced Smad1 (show SMAD1 Antibodies)-Smad5 (show SMAD5 Antibodies)-Smad8 (show SMAD9 Antibodies) phosphorylation.
Combined, these data suggest a possible pathway linking GDF5, ERG (show ERG Antibodies) and downstream factors in the processes of chondrocyte differentiation during articular joint formation.
Growth differentiation factor 5 is a novel target-derived factor that promotes sympathetic axon growth and branching and makes a distinctive regional contribution to the establishment of sympathetic innervation.
Dach2 (show DACH2 Antibodies) and Hdac9 (show HDAC9 Antibodies) mediate the effects of muscle activity on muscle reinnervation; Myog (show MYOG Antibodies) and Gdf5 appear to stimulate muscle reinnervation through parallel pathways
Gdf-5 induced the expression of the alpha5 sub-unit, while Bmp-7 (show BMP7 Antibodies) induced the expression of the alphaV sub-unit.
Clonal expansion of Gdf5 progenitors contributes to linear growth of the enthesis.
These results suggest that the SNP of the GDF5 gene could be a very useful genetic marker for body measurement traits in the bovine reproduction and breeding.
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type\; brachydactyly, type C\; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.
growth factor GDF5
, growth differentiation factor 5
, growth/differentiation factor 5-like
, cartilage-derived morphogenetic protein-1
, growth/differentiation factor 5
, cartilage-derived morphogenetic protein 1
, growth differentiation factor 5 preproprotein
, growth differentiation factor 5 (cartilage-derived morphogenetic protein-1)