anti-Growth Factor Receptor-Bound Protein 14 (GRB14) Antibodies

Mouse (Murine) Growth Factor Receptor-Bound Protein 14 (GRB14) interaction partners

1. Study reveals that Grb14 acts as a new signaling node that regulates lipogenesis and modulates insulin sensitivity in the liver by acting at a crossroad between the insulin receptor and the p62-Nrf2-LXR signaling pathways.

2. The phosphorylation status of the BPS region of Grb14 determines the positive or negative role it will play in insulin receptor (show INSR Antibodies) signaling.

3. Data show that Grb14 inhibits the activity of PTP1B (show PTPN1 Antibodies) in retina in a phosphorylation-regulated (show PHAX Antibodies) manner, and that rhodopsin (show RHO Antibodies)-regulated Src kinase (show CSK Antibodies) activation in retina leads to the phosphorylation of Grb14.

4. Grb14 is a normal physiological modulator of CNG (show CNGA1 Antibodies) channel function in vivo.

5. Grb14 functions in vivo as a tissue-specific modulator of insulin (show INS Antibodies) action, most likely via repression of IR-mediated IRS-1 (show IRS1 Antibodies) tyrosine phosphorylation

6. regulation of Grb14 expression in adipose tissue may play a physiological role in insulin (show INS Antibodies) sensitivity

7. Grb14 exerts a dual role on the regulation by insulin (show INS Antibodies) of hepatic metabolism. It inhibits insulin receptor (show INSR Antibodies) catalytic activity, and as a sterol regulatory element binding protein (show CNBP Antibodies)-1c maturation.

8. These results demonstrate that Grb14 can undergo subcellular redistribution upon illumination and suggest that rhodopsin (show RHO Antibodies) photoexcitation may trigger signaling events alternative to the classical transducin (show GNAT1 Antibodies) activation.

9. Grb10 (show GRB10 Antibodies) and Grb14 have roles in regulation of insulin (show INS Antibodies) signaling and glucose homeostasis

Human Growth Factor Receptor-Bound Protein 14 (GRB14) interaction partners

1. We investigated the modification of air pollution and diabetes association by a genetic risk score covering 63 T2D genes. Five single variants near GRB14, UBE2E2 (show UBE2E2 Antibodies), PTPRD (show PTPRD Antibodies), VPS26A (show VPS26A Antibodies) and KCNQ1 (show KCNQ1 Antibodies) showed nominally significant interactions with PM10 (P<0.05). Our results suggest that genetic risk for T2D may modify susceptibility to air pollution through alterations in insulin (show INS Antibodies) sensitivity.

2. The N-terminus of the BPS domain plays an important role in the regulation of human Grb14 and insulin receptor (show INSR Antibodies) complex formation through phosphorylation, in addition to other domains.

3. Data suggest that GRB10 (show GRB10 Antibodies) and GRB14 are both Ca2 (show CA2 Antibodies)+-dependent CaM-binding proteins; more than one CaM-binding site and/or accessory CaM-binding sites appear to exist in GRB10 (show GRB10 Antibodies) and GRB14, as compared to a single one present in GRB7 (show GRB7 Antibodies). (GRB10 (show GRB10 Antibodies) = growth factor receptor-bound protein 10 (show GRB10 Antibodies); GRB14 = growth factor receptor-bound protein 14; CaM = calmodulin; GRB7 (show GRB7 Antibodies) = growth factor receptor-bound protein 7 (show GRB7 Antibodies))

4. Colorectal cancer patients with high GRB14 levels had a shorter survival and GRB14 was upregulated at an advanced clinical stage with enhanced tumor invasion and lymph node metastasis.

5. Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor (show INSR Antibodies).

6. Genes within recently identified loci associated with waist-hip ratio (WHR) exhibit fat depot-specific mRNA expression, which correlates with obesity-related traits. Adipose tissue (AT) mRNA expression of 6 genes (TBX15 (show TBX15 Antibodies)/WARS2 (show WARS2 Antibodies), STAB1 (show STAB1 Antibodies), PIGC (show PIGC Antibodies), ZNRF3 (show ZNRF3 Antibodies), GRB14

7. Modulation of mouse rod photoreceptor responses by Grb14 protein.

8. ANKRD55 rs459193 and GRB14 rs13389219 associate with insulin (show INS Antibodies) resistance.

9. Studies indicate that insulin receptor (IR (show INSR Antibodies)) and IGF Type 1 Receptor (IGFR) have been identified as important partners of Grb10 (show GRB10 Antibodies)/14 and SH2B1 (show SH2B1 Antibodies)/B2 adaptors.

10. Grb14 is the first negative regulator of CEACAM3 (show CEACAM3 Antibodies)-initiated bacterial phagocytosis and might help to focus granulocyte responses to the subcellular sites of pathogen-host cell contact

Cow (Bovine) Growth Factor Receptor-Bound Protein 14 (GRB14) interaction partners

1. These findings suggest that Grb14 may play a regulatory role in granulosa cells during follicular deviation in cattle.

2. The growth factor receptor (show RYK Antibodies) bound protein (Grb) 14 NPXY motif could be acting as a dominant negative for insulin receptor (show INSR Antibodies) substrate (IRS)-1 (show IRS1 Antibodies) functions in the retina.

3. Grb14 contains a phosphorylated insulin receptor interacting domain between the pleckstrin homolog) and SH2 domains that binds to and forms a specific complex with the cytoplasmic domain of IRbeta