anti-Growth Factor Receptor-Bound Protein 14 (GRB14) Antibodies

The product of GRB14 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. Additionally we are shipping GRB14 Kits (31) and GRB14 Proteins (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GRB14 50915 Q9JLM9
GRB14 58844 O88900
GRB14 2888 Q14449
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online

Top anti-GRB14 Antibodies at

Showing 10 out of 56 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB Host: Rabbit  Target Name: Grb14  Sample Tissue: Rat Testis lysates  Antibody Dilution: 1.0 µg/mL 100 μL 2 to 3 Days
Human Rabbit Un-conjugated IP, IHC, WB Immunohistochemical analysis of GRB14 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of GRB14 expression in MOLT4 (A), COLO205 (B) whole cell lysates. 200 μL 13 to 14 Days
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HuvEc/COLO/MCF-7 cells, using GRB14 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Available
Human Rabbit Un-conjugated ELISA, ICC, IF, WB Western blot analysis of extracts from COLO cells using GRB14 antibody. ABIN6275159 staining HuvEc cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL 11 to 12 Days
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human kidney labeled with Anti-GRB 14 Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL 14 to 21 Days
Human Rabbit Un-conjugated WB 100 μL 11 to 14 Days
Human Rabbit Alexa Fluor 594 IF (p)   100 μL 14 to 21 Days
Human Rabbit HRP IHC (p), WB   100 μL 14 to 21 Days
Human Rabbit FITC IF (p)   100 μL 14 to 21 Days

More Antibodies against GRB14 Interaction Partners

Mouse (Murine) Growth Factor Receptor-Bound Protein 14 (GRB14) interaction partners

  1. Study reveals that Grb14 acts as a new signaling node that regulates lipogenesis and modulates insulin sensitivity in the liver by acting at a crossroad between the insulin receptor and the p62-Nrf2-LXR signaling pathways.

  2. The phosphorylation status of the BPS region of Grb14 determines the positive or negative role it will play in insulin receptor signaling.

  3. Data show that Grb14 inhibits the activity of PTP1B in retina in a phosphorylation-regulated manner, and that rhodopsin-regulated Src kinase activation in retina leads to the phosphorylation of Grb14.

  4. Grb14 is a normal physiological modulator of CNG channel function in vivo.

  5. Grb14 functions in vivo as a tissue-specific modulator of insulin action, most likely via repression of IR-mediated IRS-1 tyrosine phosphorylation

  6. regulation of Grb14 expression in adipose tissue may play a physiological role in insulin sensitivity

  7. Grb14 exerts a dual role on the regulation by insulin of hepatic metabolism. It inhibits insulin receptor catalytic activity, and as a sterol regulatory element binding protein-1c maturation.

  8. These results demonstrate that Grb14 can undergo subcellular redistribution upon illumination and suggest that rhodopsin photoexcitation may trigger signaling events alternative to the classical transducin activation.

  9. Grb10 and Grb14 have roles in regulation of insulin signaling and glucose homeostasis

Human Growth Factor Receptor-Bound Protein 14 (GRB14) interaction partners

  1. We investigated the modification of air pollution and diabetes association by a genetic risk score covering 63 T2D genes. Five single variants near GRB14, UBE2E2, PTPRD, VPS26A and KCNQ1 showed nominally significant interactions with PM10 (P<0.05). Our results suggest that genetic risk for T2D may modify susceptibility to air pollution through alterations in insulin sensitivity.

  2. The N-terminus of the BPS domain plays an important role in the regulation of human Grb14 and insulin receptor complex formation through phosphorylation, in addition to other domains.

  3. Data suggest that GRB10 and GRB14 are both Ca2+-dependent CaM-binding proteins; more than one CaM-binding site and/or accessory CaM-binding sites appear to exist in GRB10 and GRB14, as compared to a single one present in GRB7. (GRB10 = growth factor receptor-bound protein 10; GRB14 = growth factor receptor-bound protein 14; CaM = calmodulin; GRB7 = growth factor receptor-bound protein 7)

  4. Colorectal cancer patients with high GRB14 levels had a shorter survival and GRB14 was upregulated at an advanced clinical stage with enhanced tumor invasion and lymph node metastasis.

  5. Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor.

  6. Genes within recently identified loci associated with waist-hip ratio (WHR) exhibit fat depot-specific mRNA expression, which correlates with obesity-related traits. Adipose tissue (AT) mRNA expression of 6 genes (TBX15/WARS2, STAB1, PIGC, ZNRF3, GRB14

  7. Modulation of mouse rod photoreceptor responses by Grb14 protein.

  8. ANKRD55 rs459193 and GRB14 rs13389219 associate with insulin resistance.

  9. Studies indicate that insulin receptor (IR) and IGF Type 1 Receptor (IGFR) have been identified as important partners of Grb10/14 and SH2B1/B2 adaptors.

  10. Grb14 is the first negative regulator of CEACAM3-initiated bacterial phagocytosis and might help to focus granulocyte responses to the subcellular sites of pathogen-host cell contact

  11. A new role for Grb14 in finely tuning receptor signaling and modulating thyroid cancer progression.

  12. Grb14 was recruited to FGFR1 into a trimeric complex containing also phospholipase C gamma

  13. serves as an adaptor protein to recruit 3-phosphoinositede-dependent kinase-1 to activated insulin receptor, thus promoting Akt phosphorylation and transduction of the insulin signal

  14. regulation of Grb14 expression levels in response to hormonal stimuli, and are consistent with its role as a repressor of insulin signaling where it is induced as a negative feedback mechanism.

  15. Grb14 may regulate signalling through the insulin receptor by controlling its tyrosine dephosphorylation in a site-specific manner.

  16. GRB14 is a weight-loss-responsive gene in skeletal muscle. Its observed transcriptional modulation may improve insulin signaling, with weight loss.

  17. Grb14 regulates insulin action at two levels, through insulin receptors binding and by interfering with downstream pathways.

  18. Results illuminate the membrane-recruitment mechanisms of Grb7, Grb10 and Grb14.

Cow (Bovine) Growth Factor Receptor-Bound Protein 14 (GRB14) interaction partners

  1. These findings suggest that Grb14 may play a regulatory role in granulosa cells during follicular deviation in cattle.

  2. The growth factor receptor bound protein (Grb) 14 NPXY motif could be acting as a dominant negative for insulin receptor substrate (IRS)-1 functions in the retina.

  3. Grb14 contains a phosphorylated insulin receptor interacting domain between the pleckstrin homolog) and SH2 domains that binds to and forms a specific complex with the cytoplasmic domain of IRbeta

GRB14 Antigen Profile

Protein Summary

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.

Gene names and symbols associated with GRB14

  • growth factor receptor bound protein 14 (GRB14) antibody
  • growth factor receptor bound protein 14 (grb14) antibody
  • growth factor receptor bound protein 14 (Grb14) antibody
  • AI505286 antibody
  • GRB14 antibody

Protein level used designations for GRB14

growth factor receptor-bound protein 14 , growth factor receptor-bound protein 14-like , GRB14 adapter protein , growth factor receptor bound protein 14

459695 Pan troglodytes
100390507 Callithrix jacchus
100447515 Pongo abelii
100561062 Anolis carolinensis
50915 Mus musculus
58844 Rattus norvegicus
2888 Homo sapiens
100718629 Cavia porcellus
100514075 Sus scrofa
497029 Bos taurus
100861137 Capra hircus
424183 Gallus gallus
101105217 Ovis aries
100341938 Oryctolagus cuniculus
478770 Canis lupus familiaris
Selected quality suppliers for anti-GRB14 (GRB14) Antibodies
Did you look for something else?