anti-Growth Factor Receptor-Bound Protein 14 (GRB14) Antibodies

Mouse (Murine) Growth Factor Receptor-Bound Protein 14 (GRB14) interaction partners

1. Study reveals that Grb14 acts as a new signaling node that regulates lipogenesis and modulates insulin sensitivity in the liver by acting at a crossroad between the insulin receptor and the p62-Nrf2-LXR signaling pathways.

2. The phosphorylation status of the BPS region of Grb14 determines the positive or negative role it will play in insulin receptor signaling.

3. Data show that Grb14 inhibits the activity of PTP1B in retina in a phosphorylation-regulated manner, and that rhodopsin-regulated Src kinase activation in retina leads to the phosphorylation of Grb14.

4. Grb14 is a normal physiological modulator of CNG channel function in vivo.

5. Grb14 functions in vivo as a tissue-specific modulator of insulin action, most likely via repression of IR-mediated IRS-1 tyrosine phosphorylation

6. regulation of Grb14 expression in adipose tissue may play a physiological role in insulin sensitivity

7. Grb14 exerts a dual role on the regulation by insulin of hepatic metabolism. It inhibits insulin receptor catalytic activity, and as a sterol regulatory element binding protein-1c maturation.

8. These results demonstrate that Grb14 can undergo subcellular redistribution upon illumination and suggest that rhodopsin photoexcitation may trigger signaling events alternative to the classical transducin activation.

9. Grb10 and Grb14 have roles in regulation of insulin signaling and glucose homeostasis

Human Growth Factor Receptor-Bound Protein 14 (GRB14) interaction partners

1. We investigated the modification of air pollution and diabetes association by a genetic risk score covering 63 T2D genes. Five single variants near GRB14, UBE2E2, PTPRD, VPS26A and KCNQ1 showed nominally significant interactions with PM10 (P<0.05). Our results suggest that genetic risk for T2D may modify susceptibility to air pollution through alterations in insulin sensitivity.

2. The N-terminus of the BPS domain plays an important role in the regulation of human Grb14 and insulin receptor complex formation through phosphorylation, in addition to other domains.

3. Data suggest that GRB10 and GRB14 are both Ca2+-dependent CaM-binding proteins; more than one CaM-binding site and/or accessory CaM-binding sites appear to exist in GRB10 and GRB14, as compared to a single one present in GRB7. (GRB10 = growth factor receptor-bound protein 10; GRB14 = growth factor receptor-bound protein 14; CaM = calmodulin; GRB7 = growth factor receptor-bound protein 7)

4. Colorectal cancer patients with high GRB14 levels had a shorter survival and GRB14 was upregulated at an advanced clinical stage with enhanced tumor invasion and lymph node metastasis.

5. Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor.

6. Genes within recently identified loci associated with waist-hip ratio (WHR) exhibit fat depot-specific mRNA expression, which correlates with obesity-related traits. Adipose tissue (AT) mRNA expression of 6 genes (TBX15/WARS2, STAB1, PIGC, ZNRF3, GRB14

7. Modulation of mouse rod photoreceptor responses by Grb14 protein.

8. ANKRD55 rs459193 and GRB14 rs13389219 associate with insulin resistance.

9. Studies indicate that insulin receptor (IR) and IGF Type 1 Receptor (IGFR) have been identified as important partners of Grb10/14 and SH2B1/B2 adaptors.

10. Grb14 is the first negative regulator of CEACAM3-initiated bacterial phagocytosis and might help to focus granulocyte responses to the subcellular sites of pathogen-host cell contact

11. A new role for Grb14 in finely tuning receptor signaling and modulating thyroid cancer progression.

12. Grb14 was recruited to FGFR1 into a trimeric complex containing also phospholipase C gamma

13. serves as an adaptor protein to recruit 3-phosphoinositede-dependent kinase-1 to activated insulin receptor, thus promoting Akt phosphorylation and transduction of the insulin signal

14. regulation of Grb14 expression levels in response to hormonal stimuli, and are consistent with its role as a repressor of insulin signaling where it is induced as a negative feedback mechanism.

15. Grb14 may regulate signalling through the insulin receptor by controlling its tyrosine dephosphorylation in a site-specific manner.

16. GRB14 is a weight-loss-responsive gene in skeletal muscle. Its observed transcriptional modulation may improve insulin signaling, with weight loss.

17. Grb14 regulates insulin action at two levels, through insulin receptors binding and by interfering with downstream pathways.

18. Results illuminate the membrane-recruitment mechanisms of Grb7, Grb10 and Grb14.

Cow (Bovine) Growth Factor Receptor-Bound Protein 14 (GRB14) interaction partners

1. These findings suggest that Grb14 may play a regulatory role in granulosa cells during follicular deviation in cattle.

2. The growth factor receptor bound protein (Grb) 14 NPXY motif could be acting as a dominant negative for insulin receptor substrate (IRS)-1 functions in the retina.

3. Grb14 contains a phosphorylated insulin receptor interacting domain between the pleckstrin homolog) and SH2 domains that binds to and forms a specific complex with the cytoplasmic domain of IRbeta